Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events
The consequences of once-weekly rifapentine plus isoniazid for 3 months (3HP) against latent tuberculosis infections in hemodialysis patients have not been studied before. This is the first study to evaluate the safety and tolerability of 3HP in this population and revealed a completion rate of 65.4...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-02-01
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| Series: | Journal of Microbiology, Immunology and Infection |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118218301531 |
| _version_ | 1819036255541788672 |
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| author | Shang-Yi Lin Yi-Wen Chiu Po-Liang Lu Shang-Jyh Hwang Tun-Chieh Chen Min-Han Hsieh Yen-Hsu Chen |
| author_facet | Shang-Yi Lin Yi-Wen Chiu Po-Liang Lu Shang-Jyh Hwang Tun-Chieh Chen Min-Han Hsieh Yen-Hsu Chen |
| author_sort | Shang-Yi Lin |
| collection | DOAJ |
| description | The consequences of once-weekly rifapentine plus isoniazid for 3 months (3HP) against latent tuberculosis infections in hemodialysis patients have not been studied before. This is the first study to evaluate the safety and tolerability of 3HP in this population and revealed a completion rate of 65.4%. The therapy was not associated with hepatotoxicity, but with high rates of adverse events (69.2%). Keywords: Rifapentine, 3HP, Latent tuberculosis, LTBI, Hemodialysis |
| first_indexed | 2024-12-21T08:02:37Z |
| format | Article |
| id | doaj.art-caed2e20ef6441f1a3cd62425c4e4f38 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-12-21T08:02:37Z |
| publishDate | 2019-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-caed2e20ef6441f1a3cd62425c4e4f382022-12-21T19:10:53ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822019-02-01521158162Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse eventsShang-Yi Lin0Yi-Wen Chiu1Po-Liang Lu2Shang-Jyh Hwang3Tun-Chieh Chen4Min-Han Hsieh5Yen-Hsu Chen6Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanKaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsin Chu, Taiwan; Corresponding author. Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 100 Tzyou 1st Road, Kaohsiung City, Taiwan. Fax: +886 7 322 8547.The consequences of once-weekly rifapentine plus isoniazid for 3 months (3HP) against latent tuberculosis infections in hemodialysis patients have not been studied before. This is the first study to evaluate the safety and tolerability of 3HP in this population and revealed a completion rate of 65.4%. The therapy was not associated with hepatotoxicity, but with high rates of adverse events (69.2%). Keywords: Rifapentine, 3HP, Latent tuberculosis, LTBI, Hemodialysishttp://www.sciencedirect.com/science/article/pii/S1684118218301531 |
| spellingShingle | Shang-Yi Lin Yi-Wen Chiu Po-Liang Lu Shang-Jyh Hwang Tun-Chieh Chen Min-Han Hsieh Yen-Hsu Chen Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events Journal of Microbiology, Immunology and Infection |
| title | Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events |
| title_full | Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events |
| title_fullStr | Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events |
| title_full_unstemmed | Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events |
| title_short | Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events |
| title_sort | three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients high rates of adverse events |
| url | http://www.sciencedirect.com/science/article/pii/S1684118218301531 |
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