The ABCG2 rs2231142 polymorphism and the risk of nephrolithiasis: A case–control study from the Taiwan biobank
BackgroundHyperuricemia and gout are risk factors of nephrolithiasis. However, it is unclear whether the ABCG2 gene contributes to the development of nephrolithiasis. We aimed to investigate the interaction between the ABCG2 rs2231142 variant and incident nephrolithiasis in the Taiwanese population....
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1074012/full |
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| author | Ching-Tsai Lin Ching-Tsai Lin I-Chieh Chen Yen-Ju Chen Yen-Ju Chen Yen-Ju Chen Ying-Cheng Lin Jui-Chun Chang Tsai-Jung Wang Tsai-Jung Wang Tsai-Jung Wang Wen-Nan Huang Wen-Nan Huang Yi-Hsing Chen Yi-Hsing Chen Yi-Hsing Chen Yi-Huei Chen Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen |
| author_facet | Ching-Tsai Lin Ching-Tsai Lin I-Chieh Chen Yen-Ju Chen Yen-Ju Chen Yen-Ju Chen Ying-Cheng Lin Jui-Chun Chang Tsai-Jung Wang Tsai-Jung Wang Tsai-Jung Wang Wen-Nan Huang Wen-Nan Huang Yi-Hsing Chen Yi-Hsing Chen Yi-Hsing Chen Yi-Huei Chen Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen |
| author_sort | Ching-Tsai Lin |
| collection | DOAJ |
| description | BackgroundHyperuricemia and gout are risk factors of nephrolithiasis. However, it is unclear whether the ABCG2 gene contributes to the development of nephrolithiasis. We aimed to investigate the interaction between the ABCG2 rs2231142 variant and incident nephrolithiasis in the Taiwanese population.MethodsA total of 120,267 adults aged 30–70 years were enrolled from the Taiwan Biobank data-base in this retrospective case–control study and genotyped for rs2231142. The primary outcome was the prevalence of self-reported nephrolithiasis. The odds ratio (OR) of incident nephrolithiasis was analyzed by multivariable logistic regression models with adjustment for multifactorial confounding factors. Associations of the ABCG2 rs2231142 variant with serum uric acid levels, and the incident nephrolithiasis were explored.ResultsThe frequency of rs2231142 T allele was 53%, and 8,410 participants had nephrolithiasis. The multivariable-adjusted OR (95% confidence interval) of nephrolithiasis was 1.18 (1.09–1.28) and 1.12 (1.06–1.18) for TT and GT genotypes, respectively, compared with the GG genotype (p<0.001), specifically in the male population with hyperuricemia. Higher age, male sex, hyperlipidemia, hypertension, diabetes mellitus, hyperuricemia, smoking and overweight were independent risk factors for nephrolithiasis. In contrast, regular physical exercise is a protective factor against nephrolithiasis.ConclusionsABCG2 genetic variation is a significant risk of nephrolithiasis, independent of serum uric acid levels. For rs2231142 T allele carriers, our result provides evidence for precision healthcare to tackle hyperuricemia, comorbidities, smoking, and overweight, and recommend regular physical exercise for the prevention of nephrolithiasis. |
| first_indexed | 2024-04-10T04:33:19Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T04:33:19Z |
| publishDate | 2023-03-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-caedd9d89e884ae78209a686f317f3ef2023-03-10T05:33:21ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.10740121074012The ABCG2 rs2231142 polymorphism and the risk of nephrolithiasis: A case–control study from the Taiwan biobankChing-Tsai Lin0Ching-Tsai Lin1I-Chieh Chen2Yen-Ju Chen3Yen-Ju Chen4Yen-Ju Chen5Ying-Cheng Lin6Jui-Chun Chang7Tsai-Jung Wang8Tsai-Jung Wang9Tsai-Jung Wang10Wen-Nan Huang11Wen-Nan Huang12Yi-Hsing Chen13Yi-Hsing Chen14Yi-Hsing Chen15Yi-Huei Chen16Ching-Heng Lin17Ching-Heng Lin18Ching-Heng Lin19Ching-Heng Lin20Ching-Heng Lin21Ching-Heng Lin22Yi-Ming Chen23Yi-Ming Chen24Yi-Ming Chen25Yi-Ming Chen26Yi-Ming Chen27Yi-Ming Chen28Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Obstetrics and Genecology and Women’s Helath, Taichung Veterans General Hospital, Taichung, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDivision of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Critical Care Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan0Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan1Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan2Institute of Public Health and Community Medicine Research Center, National Yang Ming Chiao Tung University, Taipei City, Taiwan3Department of Internal Medicine, China Medical University Hospital, Taichung, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan4Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine & Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan5Precision Medicine Research Center, College of Medicine, National Chung Hsing University, Taichung, TaiwanBackgroundHyperuricemia and gout are risk factors of nephrolithiasis. However, it is unclear whether the ABCG2 gene contributes to the development of nephrolithiasis. We aimed to investigate the interaction between the ABCG2 rs2231142 variant and incident nephrolithiasis in the Taiwanese population.MethodsA total of 120,267 adults aged 30–70 years were enrolled from the Taiwan Biobank data-base in this retrospective case–control study and genotyped for rs2231142. The primary outcome was the prevalence of self-reported nephrolithiasis. The odds ratio (OR) of incident nephrolithiasis was analyzed by multivariable logistic regression models with adjustment for multifactorial confounding factors. Associations of the ABCG2 rs2231142 variant with serum uric acid levels, and the incident nephrolithiasis were explored.ResultsThe frequency of rs2231142 T allele was 53%, and 8,410 participants had nephrolithiasis. The multivariable-adjusted OR (95% confidence interval) of nephrolithiasis was 1.18 (1.09–1.28) and 1.12 (1.06–1.18) for TT and GT genotypes, respectively, compared with the GG genotype (p<0.001), specifically in the male population with hyperuricemia. Higher age, male sex, hyperlipidemia, hypertension, diabetes mellitus, hyperuricemia, smoking and overweight were independent risk factors for nephrolithiasis. In contrast, regular physical exercise is a protective factor against nephrolithiasis.ConclusionsABCG2 genetic variation is a significant risk of nephrolithiasis, independent of serum uric acid levels. For rs2231142 T allele carriers, our result provides evidence for precision healthcare to tackle hyperuricemia, comorbidities, smoking, and overweight, and recommend regular physical exercise for the prevention of nephrolithiasis.https://www.frontiersin.org/articles/10.3389/fendo.2023.1074012/fullnephrolithiasisABCG2 rs2231142predictorssingle-nucleotide polymorphismprecision healthcare |
| spellingShingle | Ching-Tsai Lin Ching-Tsai Lin I-Chieh Chen Yen-Ju Chen Yen-Ju Chen Yen-Ju Chen Ying-Cheng Lin Jui-Chun Chang Tsai-Jung Wang Tsai-Jung Wang Tsai-Jung Wang Wen-Nan Huang Wen-Nan Huang Yi-Hsing Chen Yi-Hsing Chen Yi-Hsing Chen Yi-Huei Chen Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen Yi-Ming Chen The ABCG2 rs2231142 polymorphism and the risk of nephrolithiasis: A case–control study from the Taiwan biobank Frontiers in Endocrinology nephrolithiasis ABCG2 rs2231142 predictors single-nucleotide polymorphism precision healthcare |
| title | The ABCG2 rs2231142 polymorphism and the risk of nephrolithiasis: A case–control study from the Taiwan biobank |
| title_full | The ABCG2 rs2231142 polymorphism and the risk of nephrolithiasis: A case–control study from the Taiwan biobank |
| title_fullStr | The ABCG2 rs2231142 polymorphism and the risk of nephrolithiasis: A case–control study from the Taiwan biobank |
| title_full_unstemmed | The ABCG2 rs2231142 polymorphism and the risk of nephrolithiasis: A case–control study from the Taiwan biobank |
| title_short | The ABCG2 rs2231142 polymorphism and the risk of nephrolithiasis: A case–control study from the Taiwan biobank |
| title_sort | abcg2 rs2231142 polymorphism and the risk of nephrolithiasis a case control study from the taiwan biobank |
| topic | nephrolithiasis ABCG2 rs2231142 predictors single-nucleotide polymorphism precision healthcare |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1074012/full |
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