Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex
NALCN channel mediates sodium leak currents and is essential for neuronal activity. Here authors uncover the mechanism of how UNC79 and UNC80 interact and promote the function of NALCN channel.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30403-7 |
| _version_ | 1818005692201566208 |
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| author | Yunlu Kang Lei Chen |
| author_facet | Yunlu Kang Lei Chen |
| author_sort | Yunlu Kang |
| collection | DOAJ |
| description | NALCN channel mediates sodium leak currents and is essential for neuronal activity. Here authors uncover the mechanism of how UNC79 and UNC80 interact and promote the function of NALCN channel. |
| first_indexed | 2024-04-14T04:48:35Z |
| format | Article |
| id | doaj.art-caedf39c2ecd4879b5180122e099eda1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T04:48:35Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-caedf39c2ecd4879b5180122e099eda12022-12-22T02:11:22ZengNature PortfolioNature Communications2041-17232022-05-0113111010.1038/s41467-022-30403-7Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complexYunlu Kang0Lei Chen1State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking. University, Beijing Key Laboratory of Cardiometabolic Molecular MedicineState Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking. University, Beijing Key Laboratory of Cardiometabolic Molecular MedicineNALCN channel mediates sodium leak currents and is essential for neuronal activity. Here authors uncover the mechanism of how UNC79 and UNC80 interact and promote the function of NALCN channel.https://doi.org/10.1038/s41467-022-30403-7 |
| spellingShingle | Yunlu Kang Lei Chen Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex Nature Communications |
| title | Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex |
| title_full | Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex |
| title_fullStr | Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex |
| title_full_unstemmed | Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex |
| title_short | Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex |
| title_sort | structure and mechanism of nalcn fam155a unc79 unc80 channel complex |
| url | https://doi.org/10.1038/s41467-022-30403-7 |
| work_keys_str_mv | AT yunlukang structureandmechanismofnalcnfam155aunc79unc80channelcomplex AT leichen structureandmechanismofnalcnfam155aunc79unc80channelcomplex |