Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels

Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels

Sigma1 receptor protein (Sigmar1) is a small, multifunctional molecular chaperone protein ubiquitously expressed in almost all body tissues. This protein has previously shown its cardioprotective roles in rodent models of cardiac hypertrophy, heart failure, and ischemia-reperfusion injury. Extensive...

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Bibliographic Details
Main Authors: Naznin Sultana Remex, Chowdhury S. Abdullah, Richa Aishwarya, Sadia S. Nitu, James Traylor, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, Christopher G. Kevil, A. Wayne Orr, Md. Shenuarin Bhuiyan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Physiology
Subjects:
SIGMAR1
physiological function
lung
fibrosis
inflammation
surfactant protein
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1118770/full

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