Epigenetic Regulation in Kidney Transplantation
Kidney transplantation is a standard care for end stage renal disease, but it is also associated with a complex pathogenesis including ischemia-reperfusion injury, inflammation, and development of fibrosis. Over the past decade, accumulating evidence has suggested a role of epigenetic regulation in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.861498/full |
| _version_ | 1818368368775790592 |
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| author | Xiaohong Xiang Xiaohong Xiang Xiaohong Xiang Jiefu Zhu Guie Dong Zheng Dong Zheng Dong |
| author_facet | Xiaohong Xiang Xiaohong Xiang Xiaohong Xiang Jiefu Zhu Guie Dong Zheng Dong Zheng Dong |
| author_sort | Xiaohong Xiang |
| collection | DOAJ |
| description | Kidney transplantation is a standard care for end stage renal disease, but it is also associated with a complex pathogenesis including ischemia-reperfusion injury, inflammation, and development of fibrosis. Over the past decade, accumulating evidence has suggested a role of epigenetic regulation in kidney transplantation, involving DNA methylation, histone modification, and various kinds of non-coding RNAs. Here, we analyze these recent studies supporting the role of epigenetic regulation in different pathological processes of kidney transplantation, i.e., ischemia-reperfusion injury, acute rejection, and chronic graft pathologies including renal interstitial fibrosis. Further investigation of epigenetic alterations, their pathological roles and underlying mechanisms in kidney transplantation may lead to new strategies for the discovery of novel diagnostic biomarkers and therapeutic interventions. |
| first_indexed | 2024-12-13T23:06:51Z |
| format | Article |
| id | doaj.art-caeecb8b5b1e4d908f425dd9a22f2d4d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T23:06:51Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-caeecb8b5b1e4d908f425dd9a22f2d4d2022-12-21T23:28:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-04-011310.3389/fimmu.2022.861498861498Epigenetic Regulation in Kidney TransplantationXiaohong Xiang0Xiaohong Xiang1Xiaohong Xiang2Jiefu Zhu3Guie Dong4Zheng Dong5Zheng Dong6Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood Veteran Affairs (VA) Medical Center, Augusta, GA, United StatesDepartment of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaCenter of Nephrology and Dialysis, Transplantation, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood Veteran Affairs (VA) Medical Center, Augusta, GA, United StatesDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood Veteran Affairs (VA) Medical Center, Augusta, GA, United StatesKidney transplantation is a standard care for end stage renal disease, but it is also associated with a complex pathogenesis including ischemia-reperfusion injury, inflammation, and development of fibrosis. Over the past decade, accumulating evidence has suggested a role of epigenetic regulation in kidney transplantation, involving DNA methylation, histone modification, and various kinds of non-coding RNAs. Here, we analyze these recent studies supporting the role of epigenetic regulation in different pathological processes of kidney transplantation, i.e., ischemia-reperfusion injury, acute rejection, and chronic graft pathologies including renal interstitial fibrosis. Further investigation of epigenetic alterations, their pathological roles and underlying mechanisms in kidney transplantation may lead to new strategies for the discovery of novel diagnostic biomarkers and therapeutic interventions.https://www.frontiersin.org/articles/10.3389/fimmu.2022.861498/fullkidney transplantationepigenetic regulationDNA methylationacetylationnon-coding RNAs |
| spellingShingle | Xiaohong Xiang Xiaohong Xiang Xiaohong Xiang Jiefu Zhu Guie Dong Zheng Dong Zheng Dong Epigenetic Regulation in Kidney Transplantation Frontiers in Immunology kidney transplantation epigenetic regulation DNA methylation acetylation non-coding RNAs |
| title | Epigenetic Regulation in Kidney Transplantation |
| title_full | Epigenetic Regulation in Kidney Transplantation |
| title_fullStr | Epigenetic Regulation in Kidney Transplantation |
| title_full_unstemmed | Epigenetic Regulation in Kidney Transplantation |
| title_short | Epigenetic Regulation in Kidney Transplantation |
| title_sort | epigenetic regulation in kidney transplantation |
| topic | kidney transplantation epigenetic regulation DNA methylation acetylation non-coding RNAs |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.861498/full |
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