Berberine Improves Benign Prostatic Hyperplasia via Suppression of 5 Alpha Reductase and Extracellular Signal-Regulated Kinase in Vivo and in Vitro

Berberine Improves Benign Prostatic Hyperplasia via Suppression of 5 Alpha Reductase and Extracellular Signal-Regulated Kinase in Vivo and in Vitro

Benign prostate hyperplasia (BPH) is a common disease in elderly men, characterized by proliferated prostate and urinary tract symptoms. The hormonal cascade starting by the action of 5-alpha-reductase (5AR) is known to be one of the pathways responsible for the pathogenesis of BPH. Present investig...

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Bibliographic Details
Main Authors: Dong-Hyun Youn, Jinbong Park, Hye-Lin Kim, Yunu Jung, JongWook Kang, Seona Lim, Gahee Song, Hyun Jeong Kwak, Jae-Young Um
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
berberine
benign prostatic hyperplasia
5 alpha reductase
androgen receptor
mitogen-activated protein kinase
extracellular signal-regulated kinase
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00773/full

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