Inhaled therapy in cystic fibrosis: agents, devices and regimens
Key points There have been significant advances in both inhalation medicines and delivery devices with “intelligent nebulisers” and “dry-powder inhalers” becoming commonplace in CF care.; Inhaled medicines generate high levels of a drug within the airways with limited systemic effects, offering safe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2015-06-01
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| Series: | Breathe |
| Online Access: | http://breathe.ersjournals.com/content/11/2/110.full |
| _version_ | 1818449860909596672 |
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| author | Penny Agent Helen Parrott |
| author_facet | Penny Agent Helen Parrott |
| author_sort | Penny Agent |
| collection | DOAJ |
| description | Key points
There have been significant advances in both inhalation medicines and delivery devices with “intelligent nebulisers” and “dry-powder inhalers” becoming commonplace in CF care.;
Inhaled medicines generate high levels of a drug within the airways with limited systemic effects, offering safe and convenient antibiotic and mucolytic therapy for individuals with CF.;
Variations in adherence are not unique to CF; however, treatment burden is high and therefore fast inhaled drug delivery devices may assist individuals in completing the prescribed treatment regimes.;
Prescribers of inhaled medicines have a responsibility to consider, in addition to efficacy, the appropriated drug/device combination for each individual in order to promote adherence and achieve the desired clinical benefit.;
Summary
The recognised mainstay daily treatments for cystic fibrosis (CF) focus on inhaled and oral medications, airway clearance and optimised nutrition. This review discusses recent advances in inhaled therapies for the management of CF, including devices such as intelligent nebulisers, drug formulations and supporting evidence for inhaled antibiotics (for the management of chronic Pseudomonas aeruginosa) and muco-active drugs. We include practical advice for clinicians regarding the optimisation of inhalation technique and education. The influence of adherence on the use of inhaled therapies in CF is also reviewed.
Educational aims
To inform readers about the history and progression of inhaled therapies for people with CF with reference to the literature supporting current practice.;
To highlight the factors that may impact the success of inhaled therapies, including those which are device specific such as drug deposition and those which influence adherence.
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| first_indexed | 2024-12-14T20:42:08Z |
| format | Article |
| id | doaj.art-caf0e7c596434bc3ac469439f60033ab |
| institution | Directory Open Access Journal |
| issn | 1810-6838 2073-4735 |
| language | English |
| last_indexed | 2024-12-14T20:42:08Z |
| publishDate | 2015-06-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | Breathe |
| spelling | doaj.art-caf0e7c596434bc3ac469439f60033ab2022-12-21T22:48:14ZengEuropean Respiratory SocietyBreathe1810-68382073-47352015-06-0111211011810.1183/20734735.02101421014Inhaled therapy in cystic fibrosis: agents, devices and regimensPenny Agent0Helen Parrott1 Royal Brompton and Harefield NHS Foundation Trust, London, UK Royal Brompton and Harefield NHS Foundation Trust, London, UK Key points There have been significant advances in both inhalation medicines and delivery devices with “intelligent nebulisers” and “dry-powder inhalers” becoming commonplace in CF care.; Inhaled medicines generate high levels of a drug within the airways with limited systemic effects, offering safe and convenient antibiotic and mucolytic therapy for individuals with CF.; Variations in adherence are not unique to CF; however, treatment burden is high and therefore fast inhaled drug delivery devices may assist individuals in completing the prescribed treatment regimes.; Prescribers of inhaled medicines have a responsibility to consider, in addition to efficacy, the appropriated drug/device combination for each individual in order to promote adherence and achieve the desired clinical benefit.; Summary The recognised mainstay daily treatments for cystic fibrosis (CF) focus on inhaled and oral medications, airway clearance and optimised nutrition. This review discusses recent advances in inhaled therapies for the management of CF, including devices such as intelligent nebulisers, drug formulations and supporting evidence for inhaled antibiotics (for the management of chronic Pseudomonas aeruginosa) and muco-active drugs. We include practical advice for clinicians regarding the optimisation of inhalation technique and education. The influence of adherence on the use of inhaled therapies in CF is also reviewed. Educational aims To inform readers about the history and progression of inhaled therapies for people with CF with reference to the literature supporting current practice.; To highlight the factors that may impact the success of inhaled therapies, including those which are device specific such as drug deposition and those which influence adherence. ;http://breathe.ersjournals.com/content/11/2/110.full |
| spellingShingle | Penny Agent Helen Parrott Inhaled therapy in cystic fibrosis: agents, devices and regimens Breathe |
| title | Inhaled therapy in cystic fibrosis: agents, devices and regimens |
| title_full | Inhaled therapy in cystic fibrosis: agents, devices and regimens |
| title_fullStr | Inhaled therapy in cystic fibrosis: agents, devices and regimens |
| title_full_unstemmed | Inhaled therapy in cystic fibrosis: agents, devices and regimens |
| title_short | Inhaled therapy in cystic fibrosis: agents, devices and regimens |
| title_sort | inhaled therapy in cystic fibrosis agents devices and regimens |
| url | http://breathe.ersjournals.com/content/11/2/110.full |
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