Mixed dyslipidemias in primary care patients in France
Laurent Laforest1, Baishali M Ambegaonkar2, Thierry Souchet3, Vasilisa Sazonov2, Eric Van Ganse11Lyon University, Lyon, France; 2Merck and Co Inc, Whitehouse Station, NJ, USA; 3Merck, Sharp & Dohme, Paris, FranceObjective: To determine the prevalence of single and mixed dyslipidemias amo...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2012-04-01
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| Series: | Vascular Health and Risk Management |
| Online Access: | http://www.dovepress.com/mixed-dyslipidemias-in-primary-care-patients-in-france-a9732 |
| _version_ | 1811343167560089600 |
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| author | Laforest L Ambegaonkar BM Souchet T Sazonov V Van Ganse E |
| author_facet | Laforest L Ambegaonkar BM Souchet T Sazonov V Van Ganse E |
| author_sort | Laforest L |
| collection | DOAJ |
| description | Laurent Laforest1, Baishali M Ambegaonkar2, Thierry Souchet3, Vasilisa Sazonov2, Eric Van Ganse11Lyon University, Lyon, France; 2Merck and Co Inc, Whitehouse Station, NJ, USA; 3Merck, Sharp & Dohme, Paris, FranceObjective: To determine the prevalence of single and mixed dyslipidemias among patients treated with statins in clinical practice in France.Methods: This is a prospective, observational, cross-sectional, pharmacoepidemiologic study with a total of 2544 consecutive patients treated with a statin for at least 6 months.Main outcome measures: Prevalence of isolated and mixed dyslipidemias of low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triglycerides among all patients and among patients at high cardiovascular risk; clinical variables associated with attainment of lipid targets/normal levels in French national guidelines.Results: At least one dyslipidemia was present in 50.8% of all patients and in 71.1% of high-risk patients. Dyslipidemias of LDL-C, HDL-C, and triglycerides were present in 27.7%, 12.4%, and 28.7% of all patients, respectively, and in 51.0%, 18.2%, and 32.5% of high-risk patients, respectively. Among all subjects with any dyslipidemia, 30.9% had mixed dyslipidemias and 69.4% had low HDL-C and/or elevated triglycerides, while 30.6% had isolated elevated LDL-C; corresponding values for high-risk patients were 36.8%, 58.9%, and 41.1%. Age, gender, body mass index and Framingham Risk Score >20% were the factors significantly associated with attainment of normal levels for ≥2 lipid levels.Conclusions: At least one dyslipidemia persisted in half of all patients and two-thirds of high cardiovascular risk patients treated with a statin. Dyslipidemias of HDL-C and/or triglycerides were as prevalent as elevated LDL-C among high cardiovascular risk patients.Keywords: cholesterol, triglycerides, dyslipidemias, prevalence, treatment outcome, France |
| first_indexed | 2024-04-13T19:23:50Z |
| format | Article |
| id | doaj.art-caf11b45e9344467844dc73ed3b2b33c |
| institution | Directory Open Access Journal |
| issn | 1176-6344 1178-2048 |
| language | English |
| last_indexed | 2024-04-13T19:23:50Z |
| publishDate | 2012-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-caf11b45e9344467844dc73ed3b2b33c2022-12-22T02:33:25ZengDove Medical PressVascular Health and Risk Management1176-63441178-20482012-04-012012default247254Mixed dyslipidemias in primary care patients in FranceLaforest LAmbegaonkar BMSouchet TSazonov VVan Ganse ELaurent Laforest1, Baishali M Ambegaonkar2, Thierry Souchet3, Vasilisa Sazonov2, Eric Van Ganse11Lyon University, Lyon, France; 2Merck and Co Inc, Whitehouse Station, NJ, USA; 3Merck, Sharp & Dohme, Paris, FranceObjective: To determine the prevalence of single and mixed dyslipidemias among patients treated with statins in clinical practice in France.Methods: This is a prospective, observational, cross-sectional, pharmacoepidemiologic study with a total of 2544 consecutive patients treated with a statin for at least 6 months.Main outcome measures: Prevalence of isolated and mixed dyslipidemias of low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triglycerides among all patients and among patients at high cardiovascular risk; clinical variables associated with attainment of lipid targets/normal levels in French national guidelines.Results: At least one dyslipidemia was present in 50.8% of all patients and in 71.1% of high-risk patients. Dyslipidemias of LDL-C, HDL-C, and triglycerides were present in 27.7%, 12.4%, and 28.7% of all patients, respectively, and in 51.0%, 18.2%, and 32.5% of high-risk patients, respectively. Among all subjects with any dyslipidemia, 30.9% had mixed dyslipidemias and 69.4% had low HDL-C and/or elevated triglycerides, while 30.6% had isolated elevated LDL-C; corresponding values for high-risk patients were 36.8%, 58.9%, and 41.1%. Age, gender, body mass index and Framingham Risk Score >20% were the factors significantly associated with attainment of normal levels for ≥2 lipid levels.Conclusions: At least one dyslipidemia persisted in half of all patients and two-thirds of high cardiovascular risk patients treated with a statin. Dyslipidemias of HDL-C and/or triglycerides were as prevalent as elevated LDL-C among high cardiovascular risk patients.Keywords: cholesterol, triglycerides, dyslipidemias, prevalence, treatment outcome, Francehttp://www.dovepress.com/mixed-dyslipidemias-in-primary-care-patients-in-france-a9732 |
| spellingShingle | Laforest L Ambegaonkar BM Souchet T Sazonov V Van Ganse E Mixed dyslipidemias in primary care patients in France Vascular Health and Risk Management |
| title | Mixed dyslipidemias in primary care patients in France |
| title_full | Mixed dyslipidemias in primary care patients in France |
| title_fullStr | Mixed dyslipidemias in primary care patients in France |
| title_full_unstemmed | Mixed dyslipidemias in primary care patients in France |
| title_short | Mixed dyslipidemias in primary care patients in France |
| title_sort | mixed dyslipidemias in primary care patients in france |
| url | http://www.dovepress.com/mixed-dyslipidemias-in-primary-care-patients-in-france-a9732 |
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