Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer
Obesity, diabetes, and inflammation increase the risk of breast cancer, the most common malignancy in women. One of the mainstays of breast cancer treatment and improving outcomes is early detection through imaging-based screening. There may be a role for individualized imaging strategies for patien...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/5/2757 |
| _version_ | 1797542142871076864 |
|---|---|
| author | Braden Miller Hunter Chalfant Alexandra Thomas Elizabeth Wellberg Christina Henson Molly W. McNally William E. Grizzle Ajay Jain Lacey R. McNally |
| author_facet | Braden Miller Hunter Chalfant Alexandra Thomas Elizabeth Wellberg Christina Henson Molly W. McNally William E. Grizzle Ajay Jain Lacey R. McNally |
| author_sort | Braden Miller |
| collection | DOAJ |
| description | Obesity, diabetes, and inflammation increase the risk of breast cancer, the most common malignancy in women. One of the mainstays of breast cancer treatment and improving outcomes is early detection through imaging-based screening. There may be a role for individualized imaging strategies for patients with certain co-morbidities. Herein, we review the literature regarding the accuracy of conventional imaging modalities in obese and diabetic women, the potential role of anti-inflammatory agents to improve detection, and the novel molecular imaging techniques that may have a role for breast cancer screening in these patients. We demonstrate that with conventional imaging modalities, increased sensitivity often comes with a loss of specificity, resulting in unnecessary biopsies and overtreatment. Obese women have body size limitations that impair image quality, and diabetes increases the risk for dense breast tis-sue. Increased density is known to obscure the diagnosis of cancer on routine screening mammography. Novel molecu-lar imaging agents with targets such as estrogen receptor, human epidermal growth factor receptor 2 (HER2), pyrimi-dine analogues, and ligand-targeted receptor probes, among others, have potential to reduce false positive results. They can also improve detection rates with increased resolution and inform therapeutic decision making. These emerg-ing imaging techniques promise to improve breast cancer diagnosis in obese patients with diabetes who have dense breasts, but more work is needed to validate their clinical application. |
| first_indexed | 2024-03-10T13:25:31Z |
| format | Article |
| id | doaj.art-caf13f9d8d1848cfb0022204d9aab84a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:25:31Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-caf13f9d8d1848cfb0022204d9aab84a2023-11-21T09:42:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01225275710.3390/ijms22052757Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast CancerBraden Miller0Hunter Chalfant1Alexandra Thomas2Elizabeth Wellberg3Christina Henson4Molly W. McNally5William E. Grizzle6Ajay Jain7Lacey R. McNally8Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Internal Medicine, Wake Forest University School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USADepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73105, USADepartment of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73105, USAStephenson Cancer Center, Oklahoma City, OK 73104, USADepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAObesity, diabetes, and inflammation increase the risk of breast cancer, the most common malignancy in women. One of the mainstays of breast cancer treatment and improving outcomes is early detection through imaging-based screening. There may be a role for individualized imaging strategies for patients with certain co-morbidities. Herein, we review the literature regarding the accuracy of conventional imaging modalities in obese and diabetic women, the potential role of anti-inflammatory agents to improve detection, and the novel molecular imaging techniques that may have a role for breast cancer screening in these patients. We demonstrate that with conventional imaging modalities, increased sensitivity often comes with a loss of specificity, resulting in unnecessary biopsies and overtreatment. Obese women have body size limitations that impair image quality, and diabetes increases the risk for dense breast tis-sue. Increased density is known to obscure the diagnosis of cancer on routine screening mammography. Novel molecu-lar imaging agents with targets such as estrogen receptor, human epidermal growth factor receptor 2 (HER2), pyrimi-dine analogues, and ligand-targeted receptor probes, among others, have potential to reduce false positive results. They can also improve detection rates with increased resolution and inform therapeutic decision making. These emerg-ing imaging techniques promise to improve breast cancer diagnosis in obese patients with diabetes who have dense breasts, but more work is needed to validate their clinical application.https://www.mdpi.com/1422-0067/22/5/2757diabetesobesityimagingmolecular imagingbreast cancer |
| spellingShingle | Braden Miller Hunter Chalfant Alexandra Thomas Elizabeth Wellberg Christina Henson Molly W. McNally William E. Grizzle Ajay Jain Lacey R. McNally Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer International Journal of Molecular Sciences diabetes obesity imaging molecular imaging breast cancer |
| title | Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer |
| title_full | Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer |
| title_fullStr | Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer |
| title_full_unstemmed | Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer |
| title_short | Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer |
| title_sort | diabetes obesity and inflammation impact on clinical and radiographic features of breast cancer |
| topic | diabetes obesity imaging molecular imaging breast cancer |
| url | https://www.mdpi.com/1422-0067/22/5/2757 |
| work_keys_str_mv | AT bradenmiller diabetesobesityandinflammationimpactonclinicalandradiographicfeaturesofbreastcancer AT hunterchalfant diabetesobesityandinflammationimpactonclinicalandradiographicfeaturesofbreastcancer AT alexandrathomas diabetesobesityandinflammationimpactonclinicalandradiographicfeaturesofbreastcancer AT elizabethwellberg diabetesobesityandinflammationimpactonclinicalandradiographicfeaturesofbreastcancer AT christinahenson diabetesobesityandinflammationimpactonclinicalandradiographicfeaturesofbreastcancer AT mollywmcnally diabetesobesityandinflammationimpactonclinicalandradiographicfeaturesofbreastcancer AT williamegrizzle diabetesobesityandinflammationimpactonclinicalandradiographicfeaturesofbreastcancer AT ajayjain diabetesobesityandinflammationimpactonclinicalandradiographicfeaturesofbreastcancer AT laceyrmcnally diabetesobesityandinflammationimpactonclinicalandradiographicfeaturesofbreastcancer |