CNP, the Third Natriuretic Peptide: Its Biology and Significance to the Cardiovascular System
The natriuretic peptide family consists of three biologically active peptides: ANP, BNP, and CNP. CNP is more widely expressed than the other two peptides, with significant levels in the central nervous system, osteochondral system, and vascular system. The receptor that is mainly targeted by CNP is...
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MDPI AG
2022-06-01
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| Online Access: | https://www.mdpi.com/2079-7737/11/7/986 |
| _version_ | 1797433841009295360 |
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| author | Yasuaki Nakagawa Toshio Nishikimi |
| author_facet | Yasuaki Nakagawa Toshio Nishikimi |
| author_sort | Yasuaki Nakagawa |
| collection | DOAJ |
| description | The natriuretic peptide family consists of three biologically active peptides: ANP, BNP, and CNP. CNP is more widely expressed than the other two peptides, with significant levels in the central nervous system, osteochondral system, and vascular system. The receptor that is mainly targeted by CNP is GC-B, which differs from GC-A, the receptor targeted by ANP and BNP. Consequently, the actions of CNP differ somewhat from those of ANP and BNP. CNP knockout leads to severe dwarfism, and there has been important research into the role of CNP in the osteochondral system. As a result, a CNP analog is now available for clinical use in patients with achondroplasia. In the cardiovascular system, CNP and its downstream signaling are involved in the regulatory mechanisms underlying myocardial remodeling, cardiac function, vascular tone, angiogenesis, and fibrosis, among others. This review focuses on the roles of CNP in the cardiovascular system and considers its potential for clinical application in the treatment of cardiovascular diseases. |
| first_indexed | 2024-03-09T10:22:37Z |
| format | Article |
| id | doaj.art-caf35b8ef22142c389aee859b3c2aebe |
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| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T10:22:37Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-caf35b8ef22142c389aee859b3c2aebe2023-12-01T21:54:18ZengMDPI AGBiology2079-77372022-06-0111798610.3390/biology11070986CNP, the Third Natriuretic Peptide: Its Biology and Significance to the Cardiovascular SystemYasuaki Nakagawa0Toshio Nishikimi1Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara-cho, Sakyo-ku, Kyoto 606-8507, JapanThe natriuretic peptide family consists of three biologically active peptides: ANP, BNP, and CNP. CNP is more widely expressed than the other two peptides, with significant levels in the central nervous system, osteochondral system, and vascular system. The receptor that is mainly targeted by CNP is GC-B, which differs from GC-A, the receptor targeted by ANP and BNP. Consequently, the actions of CNP differ somewhat from those of ANP and BNP. CNP knockout leads to severe dwarfism, and there has been important research into the role of CNP in the osteochondral system. As a result, a CNP analog is now available for clinical use in patients with achondroplasia. In the cardiovascular system, CNP and its downstream signaling are involved in the regulatory mechanisms underlying myocardial remodeling, cardiac function, vascular tone, angiogenesis, and fibrosis, among others. This review focuses on the roles of CNP in the cardiovascular system and considers its potential for clinical application in the treatment of cardiovascular diseases.https://www.mdpi.com/2079-7737/11/7/986C-type natriuretic peptideCNPGC-BNPR-C |
| spellingShingle | Yasuaki Nakagawa Toshio Nishikimi CNP, the Third Natriuretic Peptide: Its Biology and Significance to the Cardiovascular System Biology C-type natriuretic peptide CNP GC-B NPR-C |
| title | CNP, the Third Natriuretic Peptide: Its Biology and Significance to the Cardiovascular System |
| title_full | CNP, the Third Natriuretic Peptide: Its Biology and Significance to the Cardiovascular System |
| title_fullStr | CNP, the Third Natriuretic Peptide: Its Biology and Significance to the Cardiovascular System |
| title_full_unstemmed | CNP, the Third Natriuretic Peptide: Its Biology and Significance to the Cardiovascular System |
| title_short | CNP, the Third Natriuretic Peptide: Its Biology and Significance to the Cardiovascular System |
| title_sort | cnp the third natriuretic peptide its biology and significance to the cardiovascular system |
| topic | C-type natriuretic peptide CNP GC-B NPR-C |
| url | https://www.mdpi.com/2079-7737/11/7/986 |
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