Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors
Increased expression of Down Syndrome Cell Adhesion Molecule (Dscam) is implicated in the pathogenesis of brain disorders such as Down syndrome (DS) and fragile X syndrome (FXS). Here, we show that the cellular defects caused by dysregulated Dscam levels can be ameliorated by genetic and pharmacolog...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2015-05-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/05196 |
| _version_ | 1811201089696956416 |
|---|---|
| author | Gabriella R Sterne Jung Hwan Kim Bing Ye |
| author_facet | Gabriella R Sterne Jung Hwan Kim Bing Ye |
| author_sort | Gabriella R Sterne |
| collection | DOAJ |
| description | Increased expression of Down Syndrome Cell Adhesion Molecule (Dscam) is implicated in the pathogenesis of brain disorders such as Down syndrome (DS) and fragile X syndrome (FXS). Here, we show that the cellular defects caused by dysregulated Dscam levels can be ameliorated by genetic and pharmacological inhibition of Abelson kinase (Abl) both in Dscam-overexpressing neurons and in a Drosophila model of fragile X syndrome. This study offers Abl as a potential therapeutic target for treating brain disorders associated with dysregulated Dscam expression. |
| first_indexed | 2024-04-12T02:15:01Z |
| format | Article |
| id | doaj.art-caf56b3cac0d4b5db9108de267d8e41a |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:15:01Z |
| publishDate | 2015-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-caf56b3cac0d4b5db9108de267d8e41a2022-12-22T03:52:17ZengeLife Sciences Publications LtdeLife2050-084X2015-05-01410.7554/eLife.05196Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arborsGabriella R Sterne0Jung Hwan Kim1Bing Ye2Life Sciences Institute, University of Michigan, Ann Arbor, United States; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United StatesLife Sciences Institute, University of Michigan, Ann Arbor, United States; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United StatesLife Sciences Institute, University of Michigan, Ann Arbor, United States; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United StatesIncreased expression of Down Syndrome Cell Adhesion Molecule (Dscam) is implicated in the pathogenesis of brain disorders such as Down syndrome (DS) and fragile X syndrome (FXS). Here, we show that the cellular defects caused by dysregulated Dscam levels can be ameliorated by genetic and pharmacological inhibition of Abelson kinase (Abl) both in Dscam-overexpressing neurons and in a Drosophila model of fragile X syndrome. This study offers Abl as a potential therapeutic target for treating brain disorders associated with dysregulated Dscam expression.https://elifesciences.org/articles/05196DscamAblfragile X syndrometyrosine kinase inhibitorpresynaptic terminalneuronal development |
| spellingShingle | Gabriella R Sterne Jung Hwan Kim Bing Ye Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors eLife Dscam Abl fragile X syndrome tyrosine kinase inhibitor presynaptic terminal neuronal development |
| title | Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors |
| title_full | Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors |
| title_fullStr | Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors |
| title_full_unstemmed | Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors |
| title_short | Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors |
| title_sort | dysregulated dscam levels act through abelson tyrosine kinase to enlarge presynaptic arbors |
| topic | Dscam Abl fragile X syndrome tyrosine kinase inhibitor presynaptic terminal neuronal development |
| url | https://elifesciences.org/articles/05196 |
| work_keys_str_mv | AT gabriellarsterne dysregulateddscamlevelsactthroughabelsontyrosinekinasetoenlargepresynapticarbors AT junghwankim dysregulateddscamlevelsactthroughabelsontyrosinekinasetoenlargepresynapticarbors AT bingye dysregulateddscamlevelsactthroughabelsontyrosinekinasetoenlargepresynapticarbors |