B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions
B cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions. Forkhead box P3 (FoxP3)-expressing regulatory T cells (Tregs) are key players in sustaining immune tolerance and keepi...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.991840/full |
| _version_ | 1798000481889419264 |
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| author | Diaoyi Tan Diaoyi Tan Wei Yin Fei Guan Wanjiang Zeng Pamela Lee Fabio Candotti Louisa K James Niels Olsen Saraiva Camara S.M. Mansour Haeryfar Yan Chen Kamel Benlagha Lewis Zhichang Shi Jiahui Lei Quan Gong Quan Gong Zheng Liu Chaohong Liu |
| author_facet | Diaoyi Tan Diaoyi Tan Wei Yin Fei Guan Wanjiang Zeng Pamela Lee Fabio Candotti Louisa K James Niels Olsen Saraiva Camara S.M. Mansour Haeryfar Yan Chen Kamel Benlagha Lewis Zhichang Shi Jiahui Lei Quan Gong Quan Gong Zheng Liu Chaohong Liu |
| author_sort | Diaoyi Tan |
| collection | DOAJ |
| description | B cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions. Forkhead box P3 (FoxP3)-expressing regulatory T cells (Tregs) are key players in sustaining immune tolerance and keeping inflammation in check. Mounting evidence suggests complex communications between B cells and Tregs. In this review, we summarize the yin-yang regulatory relationships between B cells and Tregs mainly from the perspectives of T follicular regulatory (Tfr) cells and regulatory B cells (Bregs). We discuss the regulatory effects of Tfr cells on B cell proliferation and the germinal center response. Additionally, we review the indispensable role of B cells in ensuring homeostatic Treg survival and describe the function of Bregs in promoting Treg responses. Finally, we introduce a new subset of Tregs, termed Treg-of-B cells, which are induced by B cells, lake the expression of FoxP3 but still own immunomodulatory effects. In this article, we also enumerate a sequence of research from clinical patients and experimental models to clarify the role of Tfr cells in germinal centers and the role of convention B cells and Bregs to Tregs in the context of different diseases. This review offers an updated overview of immunoregulatory networks and unveils potential targets for therapeutic interventions against cancer, autoimmune diseases and allograft rejection. |
| first_indexed | 2024-04-11T11:20:58Z |
| format | Article |
| id | doaj.art-caf5913442b44c6e8bfedb051d28009b |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T11:20:58Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-caf5913442b44c6e8bfedb051d28009b2022-12-22T04:27:02ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-09-011010.3389/fcell.2022.991840991840B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functionsDiaoyi Tan0Diaoyi Tan1Wei Yin2Fei Guan3Wanjiang Zeng4Pamela Lee5Fabio Candotti6Louisa K James7Niels Olsen Saraiva Camara8S.M. Mansour Haeryfar9Yan Chen10Kamel Benlagha11Lewis Zhichang Shi12Jiahui Lei13Quan Gong14Quan Gong15Zheng Liu16Chaohong Liu17Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, ChinaDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandCentre for Immunobiology, Bizard Institute, Queen Mary University of London, London, United KingdomDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, BrazilDepartment of Microbiology and Immunology, Western University, London, ON, Canada0The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China1Université de Paris, Institut de Recherche Saint-Louis, EMiLy, Paris, France2Department of Radiation Oncology University of Alabama at Birmingham School of Medicine (UAB-SOM) UAB Comprehensive Cancer Center, Jinzhou, ChinaDepartment of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, China3Clinical Molecular Immunology Center, School of Medicine, Yangtze University, Jinzhou, China4Department of Immunology, School of Medicine, Yangtze University, Jinzhou, China5Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, ChinaB cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions. Forkhead box P3 (FoxP3)-expressing regulatory T cells (Tregs) are key players in sustaining immune tolerance and keeping inflammation in check. Mounting evidence suggests complex communications between B cells and Tregs. In this review, we summarize the yin-yang regulatory relationships between B cells and Tregs mainly from the perspectives of T follicular regulatory (Tfr) cells and regulatory B cells (Bregs). We discuss the regulatory effects of Tfr cells on B cell proliferation and the germinal center response. Additionally, we review the indispensable role of B cells in ensuring homeostatic Treg survival and describe the function of Bregs in promoting Treg responses. Finally, we introduce a new subset of Tregs, termed Treg-of-B cells, which are induced by B cells, lake the expression of FoxP3 but still own immunomodulatory effects. In this article, we also enumerate a sequence of research from clinical patients and experimental models to clarify the role of Tfr cells in germinal centers and the role of convention B cells and Bregs to Tregs in the context of different diseases. This review offers an updated overview of immunoregulatory networks and unveils potential targets for therapeutic interventions against cancer, autoimmune diseases and allograft rejection.https://www.frontiersin.org/articles/10.3389/fcell.2022.991840/fullregulatory T cellsB cellsT follicular regulatory cellsregulatory B cells (bregs)humoral responsesgerminal center |
| spellingShingle | Diaoyi Tan Diaoyi Tan Wei Yin Fei Guan Wanjiang Zeng Pamela Lee Fabio Candotti Louisa K James Niels Olsen Saraiva Camara S.M. Mansour Haeryfar Yan Chen Kamel Benlagha Lewis Zhichang Shi Jiahui Lei Quan Gong Quan Gong Zheng Liu Chaohong Liu B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions Frontiers in Cell and Developmental Biology regulatory T cells B cells T follicular regulatory cells regulatory B cells (bregs) humoral responses germinal center |
| title | B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions |
| title_full | B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions |
| title_fullStr | B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions |
| title_full_unstemmed | B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions |
| title_short | B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions |
| title_sort | b cell t cell interplay in immune regulation a focus on follicular regulatory t and regulatory b cell functions |
| topic | regulatory T cells B cells T follicular regulatory cells regulatory B cells (bregs) humoral responses germinal center |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.991840/full |
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