Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?
Metabolic syndrome and cardiomyopathies are long-term consequences of chemo- and radiotherapy and develop long after completing the initial tumor treatment. The slow progression of such late effects might be an indication of the involvement of autoimmune processes in the development of such follow-u...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2013-02-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/348425 |
| _version_ | 1819073295048245248 |
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| author | Annekathrin Haberland Robson A.S. Santos Ingolf Schimke Gerd Wallukat |
| author_facet | Annekathrin Haberland Robson A.S. Santos Ingolf Schimke Gerd Wallukat |
| author_sort | Annekathrin Haberland |
| collection | DOAJ |
| description | Metabolic syndrome and cardiomyopathies are long-term consequences of chemo- and radiotherapy and develop long after completing the initial tumor treatment. The slow progression of such late effects might be an indication of the involvement of autoimmune processes in the development of such follow-up consequences. Functionally active autoantibodies, which permanently stimulate relevant cell receptors, might be a crucial component. Here, we report the detection of functionally active agonistic autoantibodies such as the autoantibody against the adrenergic alpha1-receptor, the muscarinic M2-receptor, and the newly discovered autoantibody against the Mas-receptor in the plasma of a cancer survivor following chemotherapy treatment. |
| first_indexed | 2024-12-21T17:51:21Z |
| format | Article |
| id | doaj.art-caf750d828964ab284bbfcf94bdcfe3f |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-21T17:51:21Z |
| publishDate | 2013-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-caf750d828964ab284bbfcf94bdcfe3f2022-12-21T18:55:21ZengKarger PublishersCase Reports in Oncology1662-65752013-02-016110410810.1159/000348425348425Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?Annekathrin HaberlandRobson A.S. SantosIngolf SchimkeGerd WallukatMetabolic syndrome and cardiomyopathies are long-term consequences of chemo- and radiotherapy and develop long after completing the initial tumor treatment. The slow progression of such late effects might be an indication of the involvement of autoimmune processes in the development of such follow-up consequences. Functionally active autoantibodies, which permanently stimulate relevant cell receptors, might be a crucial component. Here, we report the detection of functionally active agonistic autoantibodies such as the autoantibody against the adrenergic alpha1-receptor, the muscarinic M2-receptor, and the newly discovered autoantibody against the Mas-receptor in the plasma of a cancer survivor following chemotherapy treatment.http://www.karger.com/Article/FullText/348425Agonistic autoantibodiesG-protein coupled receptor autoantibodiesChemotherapyTumor therapyCardiomyopathyMetabolic syndromeLong-term disturbances |
| spellingShingle | Annekathrin Haberland Robson A.S. Santos Ingolf Schimke Gerd Wallukat Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy? Case Reports in Oncology Agonistic autoantibodies G-protein coupled receptor autoantibodies Chemotherapy Tumor therapy Cardiomyopathy Metabolic syndrome Long-term disturbances |
| title | Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy? |
| title_full | Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy? |
| title_fullStr | Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy? |
| title_full_unstemmed | Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy? |
| title_short | Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy? |
| title_sort | are agonistic autoantibodies against g protein coupled receptors involved in the development of long term side effects of tumor chemotherapy |
| topic | Agonistic autoantibodies G-protein coupled receptor autoantibodies Chemotherapy Tumor therapy Cardiomyopathy Metabolic syndrome Long-term disturbances |
| url | http://www.karger.com/Article/FullText/348425 |
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