Architecture and RNA binding of the human negative elongation factor

Architecture and RNA binding of the human negative elongation factor

Transcription regulation in metazoans often involves promoter-proximal pausing of RNA polymerase (Pol) II, which requires the 4-subunit negative elongation factor (NELF). Here we discern the functional architecture of human NELF through X-ray crystallography, protein crosslinking, biochemical assays...

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Bibliographic Details
Main Authors: Seychelle M Vos, David Pöllmann, Livia Caizzi, Katharina B Hofmann, Pascaline Rombaut, Tomasz Zimniak, Franz Herzog, Patrick Cramer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-06-01
Series:eLife
Subjects:
gene transcription
RNA polymerase II
gene regulation
promoter-proximal pausing
Online Access:https://elifesciences.org/articles/14981

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