Phantom-based image quality assessment of clinical 18F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CT
Abstract Background We assessed and compared image quality obtained with clinical 18F-FDG whole-body oncologic PET protocols used in three different, state-of-the-art digital PET/CT and two conventional PMT-based PET/CT devices. Our goal was to evaluate an improved trade-off between administered ac...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-01-01
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| Series: | EJNMMI Physics |
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| Online Access: | https://doi.org/10.1186/s40658-019-0269-4 |
| _version_ | 1818728430403846144 |
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| author | Silvano Gnesin Christine Kieffer Konstantinos Zeimpekis Jean-Pierre Papazyan Renaud Guignard John O. Prior Francis R. Verdun Thiago V. M. Lima |
| author_facet | Silvano Gnesin Christine Kieffer Konstantinos Zeimpekis Jean-Pierre Papazyan Renaud Guignard John O. Prior Francis R. Verdun Thiago V. M. Lima |
| author_sort | Silvano Gnesin |
| collection | DOAJ |
| description | Abstract Background We assessed and compared image quality obtained with clinical 18F-FDG whole-body oncologic PET protocols used in three different, state-of-the-art digital PET/CT and two conventional PMT-based PET/CT devices. Our goal was to evaluate an improved trade-off between administered activity (patient dose exposure/signal-to-noise ratio) and acquisition time (patient comfort) while preserving diagnostic information achievable with the recently introduced digital detector technology compared to previous analogue PET technology. Methods We performed list-mode (LM) PET acquisitions using a NEMA/IEC NU2 phantom, with activity concentrations of 5 kBq/mL and 25 kBq/mL for the background (9.5 L) and sphere inserts, respectively. For each device, reconstructions were obtained varying the image statistics (10, 30, 60, 90, 120, 180, and 300 s from LM data) and the number of iterations (range 1 to 10) in addition to the employed local clinical protocol setup. We measured for each reconstructed dataset: the quantitative cross-calibration, the image noise on the uniform background assessed by the coefficient of variation (COV), and the recovery coefficients (RCs) evaluated in the hot spheres. Additionally, we compared the characteristic time-activity-product (TAP) that is the product of scan time per bed position × mass-activity administered (in min·MBq/kg) across datasets. Results Good system cross-calibration was obtained for all tested datasets with < 6% deviation from the expected value was observed. For all clinical protocol settings, image noise was compatible with clinical interpretation (COV < 15%). Digital PET showed an improved background signal-to-noise ratio as compared to conventional PMT-based PET. RCs were comparable between digital and PMT-based PET datasets. Compared to PMT-based PET, digital systems provided comparable image quality with lower TAP (from ~ 40% less and up to 70% less). Conclusions This study compared the achievable clinical image quality in three state-of-the-art digital PET/CT devices (from different vendors) as well as in two conventional PMT-based PET. Reported results show that a comparable image quality is achievable with a TAP reduction of ~ 40% in digital PET. This could lead to a significant reduction of the administered mass-activity and/or scan time with direct benefits in terms of dose exposure and patient comfort. |
| first_indexed | 2024-12-17T22:29:52Z |
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| language | English |
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| spelling | doaj.art-caf7c9b8b5f44c91a53668125662e2f12022-12-21T21:30:13ZengSpringerOpenEJNMMI Physics2197-73642020-01-017111610.1186/s40658-019-0269-4Phantom-based image quality assessment of clinical 18F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CTSilvano Gnesin0Christine Kieffer1Konstantinos Zeimpekis2Jean-Pierre Papazyan3Renaud Guignard4John O. Prior5Francis R. Verdun6Thiago V. M. Lima7Institute of Radiation physics, Lausanne University Hospital, University of LausanneInstitute of Radiation physics, Lausanne University Hospital, University of LausanneDepartment of nuclear medicine, Zürich UniversitätsspitalRadiology and Medicine Nuclear Department, Genolier CliniqueDepartment of Nuclear Medicine, La Tour Medical GroupDepartment of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, University of LausanneInstitute of Radiation physics, Lausanne University Hospital, University of LausanneInstitute of Radiation physics, Lausanne University Hospital, University of LausanneAbstract Background We assessed and compared image quality obtained with clinical 18F-FDG whole-body oncologic PET protocols used in three different, state-of-the-art digital PET/CT and two conventional PMT-based PET/CT devices. Our goal was to evaluate an improved trade-off between administered activity (patient dose exposure/signal-to-noise ratio) and acquisition time (patient comfort) while preserving diagnostic information achievable with the recently introduced digital detector technology compared to previous analogue PET technology. Methods We performed list-mode (LM) PET acquisitions using a NEMA/IEC NU2 phantom, with activity concentrations of 5 kBq/mL and 25 kBq/mL for the background (9.5 L) and sphere inserts, respectively. For each device, reconstructions were obtained varying the image statistics (10, 30, 60, 90, 120, 180, and 300 s from LM data) and the number of iterations (range 1 to 10) in addition to the employed local clinical protocol setup. We measured for each reconstructed dataset: the quantitative cross-calibration, the image noise on the uniform background assessed by the coefficient of variation (COV), and the recovery coefficients (RCs) evaluated in the hot spheres. Additionally, we compared the characteristic time-activity-product (TAP) that is the product of scan time per bed position × mass-activity administered (in min·MBq/kg) across datasets. Results Good system cross-calibration was obtained for all tested datasets with < 6% deviation from the expected value was observed. For all clinical protocol settings, image noise was compatible with clinical interpretation (COV < 15%). Digital PET showed an improved background signal-to-noise ratio as compared to conventional PMT-based PET. RCs were comparable between digital and PMT-based PET datasets. Compared to PMT-based PET, digital systems provided comparable image quality with lower TAP (from ~ 40% less and up to 70% less). Conclusions This study compared the achievable clinical image quality in three state-of-the-art digital PET/CT devices (from different vendors) as well as in two conventional PMT-based PET. Reported results show that a comparable image quality is achievable with a TAP reduction of ~ 40% in digital PET. This could lead to a significant reduction of the administered mass-activity and/or scan time with direct benefits in terms of dose exposure and patient comfort.https://doi.org/10.1186/s40658-019-0269-4Digital PET/CTImage qualityDose reductionProtocol optimization |
| spellingShingle | Silvano Gnesin Christine Kieffer Konstantinos Zeimpekis Jean-Pierre Papazyan Renaud Guignard John O. Prior Francis R. Verdun Thiago V. M. Lima Phantom-based image quality assessment of clinical 18F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CT EJNMMI Physics Digital PET/CT Image quality Dose reduction Protocol optimization |
| title | Phantom-based image quality assessment of clinical 18F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CT |
| title_full | Phantom-based image quality assessment of clinical 18F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CT |
| title_fullStr | Phantom-based image quality assessment of clinical 18F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CT |
| title_full_unstemmed | Phantom-based image quality assessment of clinical 18F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CT |
| title_short | Phantom-based image quality assessment of clinical 18F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CT |
| title_sort | phantom based image quality assessment of clinical 18f fdg protocols in digital pet ct and comparison to conventional pmt based pet ct |
| topic | Digital PET/CT Image quality Dose reduction Protocol optimization |
| url | https://doi.org/10.1186/s40658-019-0269-4 |
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