Pomegranate juice protects kidneys from Cisplatin-induced nephrotoxicity
Background: Cisplatin is a potent anti-cancer agent used successfully in treatment of cancers of solid organs, but it has a high rate of nephrotoxicity. Objective: The present study was designed to study Cisplatin-induced nephrotoxicity and the nephroprotective property of pomegranate juice. Materia...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2018-01-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/70 |
| _version_ | 1797369616085811200 |
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| author | Hussain A. Aljebori Ali H. Abady Jaffar N. Jaffar Alalsaidissa |
| author_facet | Hussain A. Aljebori Ali H. Abady Jaffar N. Jaffar Alalsaidissa |
| author_sort | Hussain A. Aljebori |
| collection | DOAJ |
| description | Background: Cisplatin is a potent anti-cancer agent used successfully in treatment of cancers of solid organs, but it has a high rate of nephrotoxicity.
Objective: The present study was designed to study Cisplatin-induced nephrotoxicity and the nephroprotective property of pomegranate juice.
Materials and Methods: The experiment was performed on 36 Iraqi white male domestic rabbits. Rabbits were divided into three groups; control group (received neither pomegranate juice, no Cisplatin), Cisplatin group (received Cisplatin only), and pomegranate group (received pomegranate juice and Cisplatin).
Results: Cisplatin group showed marked reduction of renal function manifested by high levels of blood urea, serum creatinine, and low level of serum albumin.Raised levels of oxidative stress markers and severe renal parenchymal damage by histopathology.While, pomegranate group showed almost normal renal function tests and normal levels of oxidative stress markers, and normal renal parenchymal histopathology.
Conclusion: Cisplatin in a highly nephrotoxic drug, and Pomegranate juice has a nephroprotective activity against Cisplatin-induced nephrotoxicity. |
| first_indexed | 2024-03-08T17:49:28Z |
| format | Article |
| id | doaj.art-caf86a21714a4ab7b91e79c182334735 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:49:28Z |
| publishDate | 2018-01-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-caf86a21714a4ab7b91e79c1823347352024-01-02T09:16:55ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572018-01-0159410.32007/med.1936/jfacmedbagdad.v59i4.7Pomegranate juice protects kidneys from Cisplatin-induced nephrotoxicityHussain A. Aljebori0Ali H. Abady1Jaffar N. Jaffar Alalsaidissa2Dept. of Pathology, College of Medicine, University of Al- mustansiriyah.Al-Yarmouk College of Pharmacy.Dept. of Pathology,College of Medicine University of BaghdadBackground: Cisplatin is a potent anti-cancer agent used successfully in treatment of cancers of solid organs, but it has a high rate of nephrotoxicity. Objective: The present study was designed to study Cisplatin-induced nephrotoxicity and the nephroprotective property of pomegranate juice. Materials and Methods: The experiment was performed on 36 Iraqi white male domestic rabbits. Rabbits were divided into three groups; control group (received neither pomegranate juice, no Cisplatin), Cisplatin group (received Cisplatin only), and pomegranate group (received pomegranate juice and Cisplatin). Results: Cisplatin group showed marked reduction of renal function manifested by high levels of blood urea, serum creatinine, and low level of serum albumin.Raised levels of oxidative stress markers and severe renal parenchymal damage by histopathology.While, pomegranate group showed almost normal renal function tests and normal levels of oxidative stress markers, and normal renal parenchymal histopathology. Conclusion: Cisplatin in a highly nephrotoxic drug, and Pomegranate juice has a nephroprotective activity against Cisplatin-induced nephrotoxicity.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/70Cisplatin, nephrotoxicity, Pomegranate. |
| spellingShingle | Hussain A. Aljebori Ali H. Abady Jaffar N. Jaffar Alalsaidissa Pomegranate juice protects kidneys from Cisplatin-induced nephrotoxicity مجلة كلية الطب Cisplatin, nephrotoxicity, Pomegranate. |
| title | Pomegranate juice protects kidneys from Cisplatin-induced nephrotoxicity |
| title_full | Pomegranate juice protects kidneys from Cisplatin-induced nephrotoxicity |
| title_fullStr | Pomegranate juice protects kidneys from Cisplatin-induced nephrotoxicity |
| title_full_unstemmed | Pomegranate juice protects kidneys from Cisplatin-induced nephrotoxicity |
| title_short | Pomegranate juice protects kidneys from Cisplatin-induced nephrotoxicity |
| title_sort | pomegranate juice protects kidneys from cisplatin induced nephrotoxicity |
| topic | Cisplatin, nephrotoxicity, Pomegranate. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/70 |
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