The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions
Coenzyme Q (CoQ) is a key component of the respiratory chain of all eukaryotic cells. Its function is closely related to mitochondrial respiration, where it acts as an electron transporter. However, the cellular functions of coenzyme Q are multiple: it is present in all cell membranes, limiting the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/1/128 |
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| author | Francesco Pallotti Christian Bergamini Costanza Lamperti Romana Fato |
| author_facet | Francesco Pallotti Christian Bergamini Costanza Lamperti Romana Fato |
| author_sort | Francesco Pallotti |
| collection | DOAJ |
| description | Coenzyme Q (CoQ) is a key component of the respiratory chain of all eukaryotic cells. Its function is closely related to mitochondrial respiration, where it acts as an electron transporter. However, the cellular functions of coenzyme Q are multiple: it is present in all cell membranes, limiting the toxic effect of free radicals, it is a component of LDL, it is involved in the aging process, and its deficiency is linked to several diseases. Recently, it has been proposed that coenzyme Q contributes to suppressing ferroptosis, a type of iron-dependent programmed cell death characterized by lipid peroxidation. In this review, we report the latest hypotheses and theories analyzing the multiple functions of coenzyme Q. The complete knowledge of the various cellular CoQ functions is essential to provide a rational basis for its possible therapeutic use, not only in diseases characterized by primary CoQ deficiency, but also in large number of diseases in which its secondary deficiency has been found. |
| first_indexed | 2024-03-10T03:40:00Z |
| format | Article |
| id | doaj.art-caf9e4522f0a4e5dbd05e8ec49f4872f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:40:00Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-caf9e4522f0a4e5dbd05e8ec49f4872f2023-11-23T11:35:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0123112810.3390/ijms23010128The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular FunctionsFrancesco Pallotti0Christian Bergamini1Costanza Lamperti2Romana Fato3Dipartimento di Medicina e Chirurgia, Università Degli Studi dell’Insubria, 21100 Varese, ItalyDipartimento di Farmacia e Biotecnologie, FABIT, Università Degli Studi di Bologna, 40126 Bologna, ItalyUO Genetica Medica e Neurogenetica Fondazione IRCCS Istituto Neurologico C. Besta, 20133 Milano, ItalyDipartimento di Farmacia e Biotecnologie, FABIT, Università Degli Studi di Bologna, 40126 Bologna, ItalyCoenzyme Q (CoQ) is a key component of the respiratory chain of all eukaryotic cells. Its function is closely related to mitochondrial respiration, where it acts as an electron transporter. However, the cellular functions of coenzyme Q are multiple: it is present in all cell membranes, limiting the toxic effect of free radicals, it is a component of LDL, it is involved in the aging process, and its deficiency is linked to several diseases. Recently, it has been proposed that coenzyme Q contributes to suppressing ferroptosis, a type of iron-dependent programmed cell death characterized by lipid peroxidation. In this review, we report the latest hypotheses and theories analyzing the multiple functions of coenzyme Q. The complete knowledge of the various cellular CoQ functions is essential to provide a rational basis for its possible therapeutic use, not only in diseases characterized by primary CoQ deficiency, but also in large number of diseases in which its secondary deficiency has been found.https://www.mdpi.com/1422-0067/23/1/128coenzyme Q10ubiquinone-10ubiquinol-10mitochondriaOxPhosLDL |
| spellingShingle | Francesco Pallotti Christian Bergamini Costanza Lamperti Romana Fato The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions International Journal of Molecular Sciences coenzyme Q10 ubiquinone-10 ubiquinol-10 mitochondria OxPhos LDL |
| title | The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions |
| title_full | The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions |
| title_fullStr | The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions |
| title_full_unstemmed | The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions |
| title_short | The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions |
| title_sort | roles of coenzyme q in disease direct and indirect involvement in cellular functions |
| topic | coenzyme Q10 ubiquinone-10 ubiquinol-10 mitochondria OxPhos LDL |
| url | https://www.mdpi.com/1422-0067/23/1/128 |
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