Urge-tic associations in children and adolescents with Tourette syndrome
Abstract Premonitory urges preceding tics are a cardinal feature of Gilles de la Tourette syndrome (GTS), a developmental disorder usually starting during middle childhood. However, the temporal relation between urges and tics has only been investigated in adults. In 25 children and adolescents with...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-19685-5 |
| _version_ | 1797998468423221248 |
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| author | Jennifer Langelage Julius Verrel Julia Friedrich Alina Siekmann Ronja Schappert Annet Bluschke Veit Roessner Theresa Paulus Tobias Bäumer Christian Frings Christian Beste Alexander Münchau |
| author_facet | Jennifer Langelage Julius Verrel Julia Friedrich Alina Siekmann Ronja Schappert Annet Bluschke Veit Roessner Theresa Paulus Tobias Bäumer Christian Frings Christian Beste Alexander Münchau |
| author_sort | Jennifer Langelage |
| collection | DOAJ |
| description | Abstract Premonitory urges preceding tics are a cardinal feature of Gilles de la Tourette syndrome (GTS), a developmental disorder usually starting during middle childhood. However, the temporal relation between urges and tics has only been investigated in adults. In 25 children and adolescents with GTS (8–18 years), we assess urge-tic associations, including inter-individual differences, correlation to clinical measures, and in comparison to a previously reported sample of adult GTS patients. Group-level analyses confirmed positive associations between urges and tics. However, at the individual level, less than half of participants showed positive associations, a similar proportion did not, and in two participants, the association was reversed. Tic expression and subjective urge levels correlated with corresponding clinical scores and participants with more severe tics during the urge monitor exhibited stronger urge-tic associations. Associations between reported urge levels and instantaneous tic intensity tended to be less pronounced in children and adolescents than in adult GTS patients. The observed heterogeneity of urge-tic associations cast doubt on the notion that tics are directly caused by urges. More severe tics may facilitate anticipation of tics and thereby lead to more pronounced urge-tic associations, consistent with a hypothesis of urges as a byproduct of tics. |
| first_indexed | 2024-04-11T10:49:12Z |
| format | Article |
| id | doaj.art-cafb20f7420e4c2db0d02b617a37664e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T10:49:12Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-cafb20f7420e4c2db0d02b617a37664e2022-12-22T04:28:58ZengNature PortfolioScientific Reports2045-23222022-09-0112111110.1038/s41598-022-19685-5Urge-tic associations in children and adolescents with Tourette syndromeJennifer Langelage0Julius Verrel1Julia Friedrich2Alina Siekmann3Ronja Schappert4Annet Bluschke5Veit Roessner6Theresa Paulus7Tobias Bäumer8Christian Frings9Christian Beste10Alexander Münchau11Institute of Systems Motor Science, Center of Brain, Behavior and Metabolism, Universität zu LübeckInstitute of Systems Motor Science, Center of Brain, Behavior and Metabolism, Universität zu LübeckInstitute of Systems Motor Science, Center of Brain, Behavior and Metabolism, Universität zu LübeckInstitute of Systems Motor Science, Center of Brain, Behavior and Metabolism, Universität zu LübeckInstitute of Systems Motor Science, Center of Brain, Behavior and Metabolism, Universität zu LübeckCognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU DresdenCognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU DresdenInstitute of Systems Motor Science, Center of Brain, Behavior and Metabolism, Universität zu LübeckInstitute of Systems Motor Science, Center of Brain, Behavior and Metabolism, Universität zu LübeckCognitive Psychology, Department of Psychology, University of TrierCognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU DresdenInstitute of Systems Motor Science, Center of Brain, Behavior and Metabolism, Universität zu LübeckAbstract Premonitory urges preceding tics are a cardinal feature of Gilles de la Tourette syndrome (GTS), a developmental disorder usually starting during middle childhood. However, the temporal relation between urges and tics has only been investigated in adults. In 25 children and adolescents with GTS (8–18 years), we assess urge-tic associations, including inter-individual differences, correlation to clinical measures, and in comparison to a previously reported sample of adult GTS patients. Group-level analyses confirmed positive associations between urges and tics. However, at the individual level, less than half of participants showed positive associations, a similar proportion did not, and in two participants, the association was reversed. Tic expression and subjective urge levels correlated with corresponding clinical scores and participants with more severe tics during the urge monitor exhibited stronger urge-tic associations. Associations between reported urge levels and instantaneous tic intensity tended to be less pronounced in children and adolescents than in adult GTS patients. The observed heterogeneity of urge-tic associations cast doubt on the notion that tics are directly caused by urges. More severe tics may facilitate anticipation of tics and thereby lead to more pronounced urge-tic associations, consistent with a hypothesis of urges as a byproduct of tics.https://doi.org/10.1038/s41598-022-19685-5 |
| spellingShingle | Jennifer Langelage Julius Verrel Julia Friedrich Alina Siekmann Ronja Schappert Annet Bluschke Veit Roessner Theresa Paulus Tobias Bäumer Christian Frings Christian Beste Alexander Münchau Urge-tic associations in children and adolescents with Tourette syndrome Scientific Reports |
| title | Urge-tic associations in children and adolescents with Tourette syndrome |
| title_full | Urge-tic associations in children and adolescents with Tourette syndrome |
| title_fullStr | Urge-tic associations in children and adolescents with Tourette syndrome |
| title_full_unstemmed | Urge-tic associations in children and adolescents with Tourette syndrome |
| title_short | Urge-tic associations in children and adolescents with Tourette syndrome |
| title_sort | urge tic associations in children and adolescents with tourette syndrome |
| url | https://doi.org/10.1038/s41598-022-19685-5 |
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