Polyethylenimine, an Autophagy-Inducing Platinum-Carbene-Based Drug Carrier with Potent Toxicity towards Glioblastoma Cancer Stem Cells

Polyethylenimine, an Autophagy-Inducing Platinum-Carbene-Based Drug Carrier with Potent Toxicity towards Glioblastoma Cancer Stem Cells

The difficulty involved in the treatment of many tumours due to their recurrence and resistance to chemotherapy is tightly linked to the presence of cancer stem cells (CSCs). This CSC sub-population is distinct from the majority of cancer cells of the tumour bulk. Indeed, CSCs have increased mitocho...

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Bibliographic Details
Main Authors: Conor McCartin, Candice Dussouillez, Chloé Bernhard, Eric Mathieu, Juliette Blumberger, Monique Dontenwill, Christel Herold-Mende, Ahmed Idbaih, Philippe Lavalle, Stéphane Bellemin-Laponnaz, Antoine Kichler, Sylvie Fournel
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
polymer–drug conjugate
polyethylenimine
N-heterocyclic carbene
platinum
cancer stem cells
autophagy
Online Access:https://www.mdpi.com/2072-6694/14/20/5057

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