The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma

<p>Abstract</p> <p>Background</p> <p>Elevated Glasgow Prognostic Score (GPS) has been related to poor prognosis in patients with hepatocellular carcinoma (HCC) undergoing surgical resection or receiving sorafenib. The aim of this study was to investigate the prognostic...

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Main Authors: Kinoshita Akiyoshi, Onoda Hiroshi, Imai Nami, Iwaku Akira, Oishi Mutumi, Tanaka Ken, Fushiya Nao, Koike Kazuhiko, Nishino Hirokazu, Matsushima Masato, Saeki Chisato, Tajiri Hisao
Format: Article
Language:English
Published: BMC 2013-02-01
Series:BMC Cancer
Subjects:
Online Access:http://www.biomedcentral.com/1471-2407/13/52
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author Kinoshita Akiyoshi
Onoda Hiroshi
Imai Nami
Iwaku Akira
Oishi Mutumi
Tanaka Ken
Fushiya Nao
Koike Kazuhiko
Nishino Hirokazu
Matsushima Masato
Saeki Chisato
Tajiri Hisao
author_facet Kinoshita Akiyoshi
Onoda Hiroshi
Imai Nami
Iwaku Akira
Oishi Mutumi
Tanaka Ken
Fushiya Nao
Koike Kazuhiko
Nishino Hirokazu
Matsushima Masato
Saeki Chisato
Tajiri Hisao
author_sort Kinoshita Akiyoshi
collection DOAJ
description <p>Abstract</p> <p>Background</p> <p>Elevated Glasgow Prognostic Score (GPS) has been related to poor prognosis in patients with hepatocellular carcinoma (HCC) undergoing surgical resection or receiving sorafenib. The aim of this study was to investigate the prognostic value of GPS in patients with various stages of the disease and with different liver functional status.</p> <p>Methods</p> <p>One hundred and fifty patients with newly diagnosed HCC were prospectively evaluated. Patients were divided according to their GPS scores. Univariate and multivariate analyses were performed to identify clinicopathological variables associated with overall survival; the identified variables were then compared with those of other validated staging systems.</p> <p>Results</p> <p>Elevated GPS were associated with increased asparate aminotransferase (P<0.0001), total bilirubin (P<0.0001), decreased albumin (P<0.0001), α-fetoprotein (P=0.008), larger tumor diameter (P=0.003), tumor number (P=0.041), vascular invasion (P=0.0002), extra hepatic metastasis (P=0.02), higher Child-Pugh scores (P<0.0001), and higher Cancer Liver Italian Program scores (P<0.0001). On multivariate analysis, the elevated GPS was independently associated with worse overall survival.</p> <p>Conclusions</p> <p>Our results demonstrate that the GPS can serve as an independent marker of poor prognosis in patients with HCC in various stages of disease and different liver functional status.</p>
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spelling doaj.art-cafda2814ed64b40a972dc30f9e08f622022-12-21T21:19:10ZengBMCBMC Cancer1471-24072013-02-011315210.1186/1471-2407-13-52The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinomaKinoshita AkiyoshiOnoda HiroshiImai NamiIwaku AkiraOishi MutumiTanaka KenFushiya NaoKoike KazuhikoNishino HirokazuMatsushima MasatoSaeki ChisatoTajiri Hisao<p>Abstract</p> <p>Background</p> <p>Elevated Glasgow Prognostic Score (GPS) has been related to poor prognosis in patients with hepatocellular carcinoma (HCC) undergoing surgical resection or receiving sorafenib. The aim of this study was to investigate the prognostic value of GPS in patients with various stages of the disease and with different liver functional status.</p> <p>Methods</p> <p>One hundred and fifty patients with newly diagnosed HCC were prospectively evaluated. Patients were divided according to their GPS scores. Univariate and multivariate analyses were performed to identify clinicopathological variables associated with overall survival; the identified variables were then compared with those of other validated staging systems.</p> <p>Results</p> <p>Elevated GPS were associated with increased asparate aminotransferase (P<0.0001), total bilirubin (P<0.0001), decreased albumin (P<0.0001), α-fetoprotein (P=0.008), larger tumor diameter (P=0.003), tumor number (P=0.041), vascular invasion (P=0.0002), extra hepatic metastasis (P=0.02), higher Child-Pugh scores (P<0.0001), and higher Cancer Liver Italian Program scores (P<0.0001). On multivariate analysis, the elevated GPS was independently associated with worse overall survival.</p> <p>Conclusions</p> <p>Our results demonstrate that the GPS can serve as an independent marker of poor prognosis in patients with HCC in various stages of disease and different liver functional status.</p>http://www.biomedcentral.com/1471-2407/13/52The Glasgow Prognostic ScoreHepatocellular carcinomaPrognostic marker
spellingShingle Kinoshita Akiyoshi
Onoda Hiroshi
Imai Nami
Iwaku Akira
Oishi Mutumi
Tanaka Ken
Fushiya Nao
Koike Kazuhiko
Nishino Hirokazu
Matsushima Masato
Saeki Chisato
Tajiri Hisao
The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma
BMC Cancer
The Glasgow Prognostic Score
Hepatocellular carcinoma
Prognostic marker
title The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma
title_full The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma
title_fullStr The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma
title_full_unstemmed The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma
title_short The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma
title_sort glasgow prognostic score an inflammation based prognostic score predicts survival in patients with hepatocellular carcinoma
topic The Glasgow Prognostic Score
Hepatocellular carcinoma
Prognostic marker
url http://www.biomedcentral.com/1471-2407/13/52
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