The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma
<p>Abstract</p> <p>Background</p> <p>Elevated Glasgow Prognostic Score (GPS) has been related to poor prognosis in patients with hepatocellular carcinoma (HCC) undergoing surgical resection or receiving sorafenib. The aim of this study was to investigate the prognostic...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2013-02-01
|
Series: | BMC Cancer |
Subjects: | |
Online Access: | http://www.biomedcentral.com/1471-2407/13/52 |
_version_ | 1818755585669070848 |
---|---|
author | Kinoshita Akiyoshi Onoda Hiroshi Imai Nami Iwaku Akira Oishi Mutumi Tanaka Ken Fushiya Nao Koike Kazuhiko Nishino Hirokazu Matsushima Masato Saeki Chisato Tajiri Hisao |
author_facet | Kinoshita Akiyoshi Onoda Hiroshi Imai Nami Iwaku Akira Oishi Mutumi Tanaka Ken Fushiya Nao Koike Kazuhiko Nishino Hirokazu Matsushima Masato Saeki Chisato Tajiri Hisao |
author_sort | Kinoshita Akiyoshi |
collection | DOAJ |
description | <p>Abstract</p> <p>Background</p> <p>Elevated Glasgow Prognostic Score (GPS) has been related to poor prognosis in patients with hepatocellular carcinoma (HCC) undergoing surgical resection or receiving sorafenib. The aim of this study was to investigate the prognostic value of GPS in patients with various stages of the disease and with different liver functional status.</p> <p>Methods</p> <p>One hundred and fifty patients with newly diagnosed HCC were prospectively evaluated. Patients were divided according to their GPS scores. Univariate and multivariate analyses were performed to identify clinicopathological variables associated with overall survival; the identified variables were then compared with those of other validated staging systems.</p> <p>Results</p> <p>Elevated GPS were associated with increased asparate aminotransferase (P<0.0001), total bilirubin (P<0.0001), decreased albumin (P<0.0001), α-fetoprotein (P=0.008), larger tumor diameter (P=0.003), tumor number (P=0.041), vascular invasion (P=0.0002), extra hepatic metastasis (P=0.02), higher Child-Pugh scores (P<0.0001), and higher Cancer Liver Italian Program scores (P<0.0001). On multivariate analysis, the elevated GPS was independently associated with worse overall survival.</p> <p>Conclusions</p> <p>Our results demonstrate that the GPS can serve as an independent marker of poor prognosis in patients with HCC in various stages of disease and different liver functional status.</p> |
first_indexed | 2024-12-18T05:41:29Z |
format | Article |
id | doaj.art-cafda2814ed64b40a972dc30f9e08f62 |
institution | Directory Open Access Journal |
issn | 1471-2407 |
language | English |
last_indexed | 2024-12-18T05:41:29Z |
publishDate | 2013-02-01 |
publisher | BMC |
record_format | Article |
series | BMC Cancer |
spelling | doaj.art-cafda2814ed64b40a972dc30f9e08f622022-12-21T21:19:10ZengBMCBMC Cancer1471-24072013-02-011315210.1186/1471-2407-13-52The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinomaKinoshita AkiyoshiOnoda HiroshiImai NamiIwaku AkiraOishi MutumiTanaka KenFushiya NaoKoike KazuhikoNishino HirokazuMatsushima MasatoSaeki ChisatoTajiri Hisao<p>Abstract</p> <p>Background</p> <p>Elevated Glasgow Prognostic Score (GPS) has been related to poor prognosis in patients with hepatocellular carcinoma (HCC) undergoing surgical resection or receiving sorafenib. The aim of this study was to investigate the prognostic value of GPS in patients with various stages of the disease and with different liver functional status.</p> <p>Methods</p> <p>One hundred and fifty patients with newly diagnosed HCC were prospectively evaluated. Patients were divided according to their GPS scores. Univariate and multivariate analyses were performed to identify clinicopathological variables associated with overall survival; the identified variables were then compared with those of other validated staging systems.</p> <p>Results</p> <p>Elevated GPS were associated with increased asparate aminotransferase (P<0.0001), total bilirubin (P<0.0001), decreased albumin (P<0.0001), α-fetoprotein (P=0.008), larger tumor diameter (P=0.003), tumor number (P=0.041), vascular invasion (P=0.0002), extra hepatic metastasis (P=0.02), higher Child-Pugh scores (P<0.0001), and higher Cancer Liver Italian Program scores (P<0.0001). On multivariate analysis, the elevated GPS was independently associated with worse overall survival.</p> <p>Conclusions</p> <p>Our results demonstrate that the GPS can serve as an independent marker of poor prognosis in patients with HCC in various stages of disease and different liver functional status.</p>http://www.biomedcentral.com/1471-2407/13/52The Glasgow Prognostic ScoreHepatocellular carcinomaPrognostic marker |
spellingShingle | Kinoshita Akiyoshi Onoda Hiroshi Imai Nami Iwaku Akira Oishi Mutumi Tanaka Ken Fushiya Nao Koike Kazuhiko Nishino Hirokazu Matsushima Masato Saeki Chisato Tajiri Hisao The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma BMC Cancer The Glasgow Prognostic Score Hepatocellular carcinoma Prognostic marker |
title | The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma |
title_full | The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma |
title_fullStr | The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma |
title_full_unstemmed | The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma |
title_short | The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma |
title_sort | glasgow prognostic score an inflammation based prognostic score predicts survival in patients with hepatocellular carcinoma |
topic | The Glasgow Prognostic Score Hepatocellular carcinoma Prognostic marker |
url | http://www.biomedcentral.com/1471-2407/13/52 |
work_keys_str_mv | AT kinoshitaakiyoshi theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT onodahiroshi theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT imainami theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT iwakuakira theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT oishimutumi theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT tanakaken theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT fushiyanao theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT koikekazuhiko theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT nishinohirokazu theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT matsushimamasato theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT saekichisato theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT tajirihisao theglasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT kinoshitaakiyoshi glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT onodahiroshi glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT imainami glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT iwakuakira glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT oishimutumi glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT tanakaken glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT fushiyanao glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT koikekazuhiko glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT nishinohirokazu glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT matsushimamasato glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT saekichisato glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma AT tajirihisao glasgowprognosticscoreaninflammationbasedprognosticscorepredictssurvivalinpatientswithhepatocellularcarcinoma |