Peripubertal serum concentrations of organochlorine pesticides and semen parameters in Russian young men
Background: Epidemiologic literature on the relation of organochlorine pesticides (OCPs) with semen quality among adult men has been inconclusive, and no studies have prospectively explored the association between peripubertal serum OCPs and semen parameters in young men. Objective: To evaluate pros...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-11-01
|
| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412020320407 |
| _version_ | 1818260255634620416 |
|---|---|
| author | Ramy Abou Ghayda Oleg Sergeyev Jane S. Burns Paige L. Williams Mary M. Lee Susan A. Korrick Luidmila Smigulina Yury Dikov Russ Hauser Lidia Mínguez-Alarcón |
| author_facet | Ramy Abou Ghayda Oleg Sergeyev Jane S. Burns Paige L. Williams Mary M. Lee Susan A. Korrick Luidmila Smigulina Yury Dikov Russ Hauser Lidia Mínguez-Alarcón |
| author_sort | Ramy Abou Ghayda |
| collection | DOAJ |
| description | Background: Epidemiologic literature on the relation of organochlorine pesticides (OCPs) with semen quality among adult men has been inconclusive, and no studies have prospectively explored the association between peripubertal serum OCPs and semen parameters in young men. Objective: To evaluate prospective associations of peripubertal serum concentrations of hexachlorobenzene (HCB), β-hexachlorocylohexane (β-HCH), and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) with semen parameters among young Russian men. Methods: This prospective cohort study included 152 young men who enrolled in the Russian Children’s Study (2003–2005) at age 8–9 years and were followed annually until young adulthood. HCB, β-HCH, and p,p′-DDE concentrations were measured at the CDC by mass spectrometry in serum collected at enrollment. Between 18 and 23 years, semen samples (n = 298) were provided for analysis of volume, concentration, and progressive motility; we also calculated total sperm count and total progressive motile count. Linear mixed models were used to examine the longitudinal associations of quartiles of serum HCB, β-HCH and p,p′-DDE with semen parameters, adjusting for total serum lipids, body mass index, smoking, abstinence time and baseline dietary macronutrient intake. Results: Lipid-adjusted medians (IQR) for serum HCB, βHCH and p,ṕ-DDE, respectively, were 150 ng/g lipid (102–243), 172 ng/g lipid (120–257) and 275 ng/g lipid (190–465). In adjusted models, we observed lower ejaculated volume with higher serum concentrations of HCB and βHCH, along with reduced progressive motility with higher concentrations of βHCH and p,ṕ-DDE. Men in the highest quartile of serum HCB had a mean (95% Confidence Interval, CI) ejaculated volume of 2.25 mL (1.89, 2.60), as compared to those in the lowest quartile with a mean (95% CI) of 2.97 mL (2.46, 3.49) (p = 0.03). Also, men in the highest quartile of serum p,ṕ-DDE had a mean (95% CI) progressive motility of 51.1% (48.6, 53.7), as compared to those in the lowest quartile with a mean (95% CI) of 55.1% (51.7, 58.5) (p = 0.07). Conclusion: In this longitudinal Russian cohort study, peripubertal serum concentrations of selected OCPs were associated with lower ejaculated volume and progressive motility highlighting the importance of the peripubertal window when evaluating chemical exposures in relation to semen quality. |
| first_indexed | 2024-12-12T18:28:26Z |
| format | Article |
| id | doaj.art-cafddc3d1e8f4cfcb71a6e417448edff |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-12T18:28:26Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-cafddc3d1e8f4cfcb71a6e417448edff2022-12-22T00:15:58ZengElsevierEnvironment International0160-41202020-11-01144106085Peripubertal serum concentrations of organochlorine pesticides and semen parameters in Russian young menRamy Abou Ghayda0Oleg Sergeyev1Jane S. Burns2Paige L. Williams3Mary M. Lee4Susan A. Korrick5Luidmila Smigulina6Yury Dikov7Russ Hauser8Lidia Mínguez-Alarcón9Division of Urology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAGroup of Epigenetic Epidemiology, A.N. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia; Chapaevsk Medical Association, Chapaevsk, Samara Region, Russia; Corresponding authors at: Group of Epigenetic Epidemiology, A.N. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia (O. Sergeyev) and Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA (L Minguez-Alarcon).Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USADepartment of Biostatistics and Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USADepartment of Pediatrics, Sidney Kimmel Medical College, Philadelphia, PA, USA; Nemours AI duPont Hospital for Children, Wilmington, DE, USADepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAChapaevsk Medical Association, Chapaevsk, Samara Region, RussiaGroup of Epigenetic Epidemiology, A.N. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia; Chapaevsk Medical Association, Chapaevsk, Samara Region, RussiaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USADepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Corresponding authors at: Group of Epigenetic Epidemiology, A.N. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia (O. Sergeyev) and Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA (L Minguez-Alarcon).Background: Epidemiologic literature on the relation of organochlorine pesticides (OCPs) with semen quality among adult men has been inconclusive, and no studies have prospectively explored the association between peripubertal serum OCPs and semen parameters in young men. Objective: To evaluate prospective associations of peripubertal serum concentrations of hexachlorobenzene (HCB), β-hexachlorocylohexane (β-HCH), and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) with semen parameters among young Russian men. Methods: This prospective cohort study included 152 young men who enrolled in the Russian Children’s Study (2003–2005) at age 8–9 years and were followed annually until young adulthood. HCB, β-HCH, and p,p′-DDE concentrations were measured at the CDC by mass spectrometry in serum collected at enrollment. Between 18 and 23 years, semen samples (n = 298) were provided for analysis of volume, concentration, and progressive motility; we also calculated total sperm count and total progressive motile count. Linear mixed models were used to examine the longitudinal associations of quartiles of serum HCB, β-HCH and p,p′-DDE with semen parameters, adjusting for total serum lipids, body mass index, smoking, abstinence time and baseline dietary macronutrient intake. Results: Lipid-adjusted medians (IQR) for serum HCB, βHCH and p,ṕ-DDE, respectively, were 150 ng/g lipid (102–243), 172 ng/g lipid (120–257) and 275 ng/g lipid (190–465). In adjusted models, we observed lower ejaculated volume with higher serum concentrations of HCB and βHCH, along with reduced progressive motility with higher concentrations of βHCH and p,ṕ-DDE. Men in the highest quartile of serum HCB had a mean (95% Confidence Interval, CI) ejaculated volume of 2.25 mL (1.89, 2.60), as compared to those in the lowest quartile with a mean (95% CI) of 2.97 mL (2.46, 3.49) (p = 0.03). Also, men in the highest quartile of serum p,ṕ-DDE had a mean (95% CI) progressive motility of 51.1% (48.6, 53.7), as compared to those in the lowest quartile with a mean (95% CI) of 55.1% (51.7, 58.5) (p = 0.07). Conclusion: In this longitudinal Russian cohort study, peripubertal serum concentrations of selected OCPs were associated with lower ejaculated volume and progressive motility highlighting the importance of the peripubertal window when evaluating chemical exposures in relation to semen quality.http://www.sciencedirect.com/science/article/pii/S0160412020320407Organochlorine pesticidesSemen qualityPeripubertal stage |
| spellingShingle | Ramy Abou Ghayda Oleg Sergeyev Jane S. Burns Paige L. Williams Mary M. Lee Susan A. Korrick Luidmila Smigulina Yury Dikov Russ Hauser Lidia Mínguez-Alarcón Peripubertal serum concentrations of organochlorine pesticides and semen parameters in Russian young men Environment International Organochlorine pesticides Semen quality Peripubertal stage |
| title | Peripubertal serum concentrations of organochlorine pesticides and semen parameters in Russian young men |
| title_full | Peripubertal serum concentrations of organochlorine pesticides and semen parameters in Russian young men |
| title_fullStr | Peripubertal serum concentrations of organochlorine pesticides and semen parameters in Russian young men |
| title_full_unstemmed | Peripubertal serum concentrations of organochlorine pesticides and semen parameters in Russian young men |
| title_short | Peripubertal serum concentrations of organochlorine pesticides and semen parameters in Russian young men |
| title_sort | peripubertal serum concentrations of organochlorine pesticides and semen parameters in russian young men |
| topic | Organochlorine pesticides Semen quality Peripubertal stage |
| url | http://www.sciencedirect.com/science/article/pii/S0160412020320407 |
| work_keys_str_mv | AT ramyaboughayda peripubertalserumconcentrationsoforganochlorinepesticidesandsemenparametersinrussianyoungmen AT olegsergeyev peripubertalserumconcentrationsoforganochlorinepesticidesandsemenparametersinrussianyoungmen AT janesburns peripubertalserumconcentrationsoforganochlorinepesticidesandsemenparametersinrussianyoungmen AT paigelwilliams peripubertalserumconcentrationsoforganochlorinepesticidesandsemenparametersinrussianyoungmen AT marymlee peripubertalserumconcentrationsoforganochlorinepesticidesandsemenparametersinrussianyoungmen AT susanakorrick peripubertalserumconcentrationsoforganochlorinepesticidesandsemenparametersinrussianyoungmen AT luidmilasmigulina peripubertalserumconcentrationsoforganochlorinepesticidesandsemenparametersinrussianyoungmen AT yurydikov peripubertalserumconcentrationsoforganochlorinepesticidesandsemenparametersinrussianyoungmen AT russhauser peripubertalserumconcentrationsoforganochlorinepesticidesandsemenparametersinrussianyoungmen AT lidiaminguezalarcon peripubertalserumconcentrationsoforganochlorinepesticidesandsemenparametersinrussianyoungmen |