Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases
Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo sorting from endosomal compartments. In concert with its accessory proteins, the retromer drives packaged cargoes to tubular and vesicular structures, thereby transferring them to the trans-Golgi network or to...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.897688/full |
| _version_ | 1811307973440438272 |
|---|---|
| author | Shun Yoshida Shun Yoshida Takafumi Hasegawa |
| author_facet | Shun Yoshida Shun Yoshida Takafumi Hasegawa |
| author_sort | Shun Yoshida |
| collection | DOAJ |
| description | Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo sorting from endosomal compartments. In concert with its accessory proteins, the retromer drives packaged cargoes to tubular and vesicular structures, thereby transferring them to the trans-Golgi network or to the plasma membrane. In addition to the endosomal trafficking, the retromer machinery participates in mitochondrial dynamics and autophagic processes and thus contributes to cellular homeostasis. The retromer components and their associated molecules are expressed in different types of cells including neurons and glial cells, and accumulating evidence from genetic and biochemical studies suggests that retromer dysfunction is profoundly involved in the pathogenesis of neurodegenerative diseases including Alzheimer’s Disease and Parkinson’s disease. Moreover, targeting retromer components could alleviate the neurodegenerative process, suggesting that the retromer complex may serve as a promising therapeutic target. In this review, we will provide the latest insight into the regulatory mechanisms of retromer and discuss how its dysfunction influences the pathological process leading to neurodegeneration. |
| first_indexed | 2024-04-13T09:14:46Z |
| format | Article |
| id | doaj.art-cafe8899c086468a837a664f6f3dcfa5 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T09:14:46Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-cafe8899c086468a837a664f6f3dcfa52022-12-22T02:52:46ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-05-011410.3389/fnagi.2022.897688897688Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative DiseasesShun Yoshida0Shun Yoshida1Takafumi Hasegawa2Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Neurology, National Hospital Organization Yonezawa Hospital, Yonezawa, JapanDivision of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai, JapanRetromer is a highly integrated multimeric protein complex that mediates retrograde cargo sorting from endosomal compartments. In concert with its accessory proteins, the retromer drives packaged cargoes to tubular and vesicular structures, thereby transferring them to the trans-Golgi network or to the plasma membrane. In addition to the endosomal trafficking, the retromer machinery participates in mitochondrial dynamics and autophagic processes and thus contributes to cellular homeostasis. The retromer components and their associated molecules are expressed in different types of cells including neurons and glial cells, and accumulating evidence from genetic and biochemical studies suggests that retromer dysfunction is profoundly involved in the pathogenesis of neurodegenerative diseases including Alzheimer’s Disease and Parkinson’s disease. Moreover, targeting retromer components could alleviate the neurodegenerative process, suggesting that the retromer complex may serve as a promising therapeutic target. In this review, we will provide the latest insight into the regulatory mechanisms of retromer and discuss how its dysfunction influences the pathological process leading to neurodegeneration.https://www.frontiersin.org/articles/10.3389/fnagi.2022.897688/fullretromermembrane traffickingneurodegenerationAlzheimer’s DiseaseParkinson’s disease |
| spellingShingle | Shun Yoshida Shun Yoshida Takafumi Hasegawa Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases Frontiers in Aging Neuroscience retromer membrane trafficking neurodegeneration Alzheimer’s Disease Parkinson’s disease |
| title | Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases |
| title_full | Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases |
| title_fullStr | Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases |
| title_full_unstemmed | Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases |
| title_short | Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases |
| title_sort | beware of misdelivery multifaceted role of retromer transport in neurodegenerative diseases |
| topic | retromer membrane trafficking neurodegeneration Alzheimer’s Disease Parkinson’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.897688/full |
| work_keys_str_mv | AT shunyoshida bewareofmisdeliverymultifacetedroleofretromertransportinneurodegenerativediseases AT shunyoshida bewareofmisdeliverymultifacetedroleofretromertransportinneurodegenerativediseases AT takafumihasegawa bewareofmisdeliverymultifacetedroleofretromertransportinneurodegenerativediseases |