Vitamin K1 enhances sorafenib-induced growth inhibition and apoptosis of human malignant glioma cells by blocking the Raf/MEK/ERK pathway

Vitamin K1 enhances sorafenib-induced growth inhibition and apoptosis of human malignant glioma cells by blocking the Raf/MEK/ERK pathway

<p>Abstract</p> <p>Background</p> <p>The combined effects of anticancer drugs with nutritional factors against tumor cells have been reported previously. This study characterized the efficacy and possible mechanisms of the combination of sorafenib and vitamin K1 (VK1) o...

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Bibliographic Details
Main Authors: Du Wei, Zhou Jing-ru, Wang Dong-liang, Gong Kai, Zhang Qing-jun
Format: Article
Language:English
Published: BMC 2012-04-01
Series:World Journal of Surgical Oncology
Subjects:
Apoptosis
Glioma
MAPK
Sorafenib
Vitamin K1
Online Access:http://www.wjso.com/content/10/1/60

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