Myopic (Peri)papillary Changes and Visual Field Defects
Adèle Ehongo,1 Artémise Dugauquier,1 Nacima Kisma,1 Viviane De Maertelaer,2 Brenda Nana Wandji,1 Wilfried Tchatchou Tomy,1 Yassir Alaoui Mhammedi,1 Kevin Coppens,3 Karelle Leroy,4 Francoise Bremer1 1Ophthalmology Department, Erasmus Hospital, Brussels, 1070, Belgium; 2Biostatistics, IRIBHM Universit...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-11-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/myopic-peripapillary-changes-and-visual-field-defects-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1827774005974663168 |
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| author | Ehongo A Dugauquier A Kisma N De Maertelaer V Nana Wandji B Tchatchou Tomy W Alaoui Mhammedi Y Coppens K Leroy K Bremer F |
| author_facet | Ehongo A Dugauquier A Kisma N De Maertelaer V Nana Wandji B Tchatchou Tomy W Alaoui Mhammedi Y Coppens K Leroy K Bremer F |
| author_sort | Ehongo A |
| collection | DOAJ |
| description | Adèle Ehongo,1 Artémise Dugauquier,1 Nacima Kisma,1 Viviane De Maertelaer,2 Brenda Nana Wandji,1 Wilfried Tchatchou Tomy,1 Yassir Alaoui Mhammedi,1 Kevin Coppens,3 Karelle Leroy,4 Francoise Bremer1 1Ophthalmology Department, Erasmus Hospital, Brussels, 1070, Belgium; 2Biostatistics, IRIBHM Université Libre de Bruxelles, Bruxelles, 1070, Belgium; 3Cosma consulting Sijsjesdreef 13, Enghien, 7850, Belgium; 4Laboratory of Histology, Université Libre de Bruxelles, Bruxelles, 1070, BelgiumCorrespondence: Adèle Ehongo, Ophthalmology Department, Erasmus Hospital, Route de Lennik 808, Brussels, 1070, Belgium, Tel +3225553114, Fax +3225556737, Email adele.ehongo@erasme.ulb.ac.bePurpose: Myopic eyes combining gamma peripapillary atrophy and peripapillary staphyloma were sorted according to the presence of intrachoroidal cavitation (PICCs) or its absence (combinations). Visual field defects (VFDs) and factors discriminating these groups were analyzed.Methods: These groups were sorted by optical coherence tomography. VFDs were assessed using the Humphrey® Field Analyzer 3, SITA standard. Ovality index (OI) was the ratio between the shortest and longest diameters of the disc. The proportions of PICCs, lamina cribrosa defects (LCDs) and clusters in each Garway-Heath’s sector (A—F) were analyzed. All variables were compared between PICCs and combinations. A multivariate logistic regression analysis was performed ultimately.Results: Of the 93 eyes, we obtained, 20 PICCs and 73 combinations. The prevalence of VFDs and LCDs in PICCs were 65% (13/20) and 30% (6/20), respectively. PICCs 85% (17/20) and LCDs 12% (11/93) predominated in sector B (inferotemporal) and clusters 9.7% (9/93) in the corresponding sector. The proportion of VFDs was significantly higher in PICCs than combinations (p < 0.001). In sector B, the proportion of LCDs was significantly higher in PICCs than combinations (p = 0.011). The mean OI was significantly lower (p < 0.001) in PICCs than combinations. Multivariate logistic regression analysis concluded that mean OI (p < 0.001) was the only statistically significant factor discriminating PICCs and combinations.Conclusion: Mean OI discriminating PICCs from combinations is further evidence of a gradation of structural changes between them. It could be related to the higher proportion of VFDs in PICCs. The predominant distribution of PICCs infero-temporally supports PICC as a cause of uncertainty in glaucoma diagnosis in high myopia. Furthermore, the highest proportion of PICCs and LCDs in this sector highlights its vulnerability to damage in myopic eyes and deserves further investigation as it is also primarily involved in glaucoma.Keywords: peripapillary intrachoroidal cavitation, visual field defects, peripapillary staphyloma, gamma peripapillary atrophy, ovality index, lamina cribrosa defects, glaucoma, myopic complications |
| first_indexed | 2024-03-11T13:31:58Z |
| format | Article |
| id | doaj.art-cb00d37dd12b41aba9eafd8ab981e240 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-03-11T13:31:58Z |
| publishDate | 2023-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-cb00d37dd12b41aba9eafd8ab981e2402023-11-02T17:13:57ZengDove Medical PressClinical Ophthalmology1177-54832023-11-01Volume 173295330687788Myopic (Peri)papillary Changes and Visual Field DefectsEhongo ADugauquier AKisma NDe Maertelaer VNana Wandji BTchatchou Tomy WAlaoui Mhammedi YCoppens KLeroy KBremer FAdèle Ehongo,1 Artémise Dugauquier,1 Nacima Kisma,1 Viviane De Maertelaer,2 Brenda Nana Wandji,1 Wilfried Tchatchou Tomy,1 Yassir Alaoui Mhammedi,1 Kevin Coppens,3 Karelle Leroy,4 Francoise Bremer1 1Ophthalmology Department, Erasmus Hospital, Brussels, 1070, Belgium; 2Biostatistics, IRIBHM Université Libre de Bruxelles, Bruxelles, 1070, Belgium; 3Cosma consulting Sijsjesdreef 13, Enghien, 7850, Belgium; 4Laboratory of Histology, Université Libre de Bruxelles, Bruxelles, 1070, BelgiumCorrespondence: Adèle Ehongo, Ophthalmology Department, Erasmus Hospital, Route de Lennik 808, Brussels, 1070, Belgium, Tel +3225553114, Fax +3225556737, Email adele.ehongo@erasme.ulb.ac.bePurpose: Myopic eyes combining gamma peripapillary atrophy and peripapillary staphyloma were sorted according to the presence of intrachoroidal cavitation (PICCs) or its absence (combinations). Visual field defects (VFDs) and factors discriminating these groups were analyzed.Methods: These groups were sorted by optical coherence tomography. VFDs were assessed using the Humphrey® Field Analyzer 3, SITA standard. Ovality index (OI) was the ratio between the shortest and longest diameters of the disc. The proportions of PICCs, lamina cribrosa defects (LCDs) and clusters in each Garway-Heath’s sector (A—F) were analyzed. All variables were compared between PICCs and combinations. A multivariate logistic regression analysis was performed ultimately.Results: Of the 93 eyes, we obtained, 20 PICCs and 73 combinations. The prevalence of VFDs and LCDs in PICCs were 65% (13/20) and 30% (6/20), respectively. PICCs 85% (17/20) and LCDs 12% (11/93) predominated in sector B (inferotemporal) and clusters 9.7% (9/93) in the corresponding sector. The proportion of VFDs was significantly higher in PICCs than combinations (p < 0.001). In sector B, the proportion of LCDs was significantly higher in PICCs than combinations (p = 0.011). The mean OI was significantly lower (p < 0.001) in PICCs than combinations. Multivariate logistic regression analysis concluded that mean OI (p < 0.001) was the only statistically significant factor discriminating PICCs and combinations.Conclusion: Mean OI discriminating PICCs from combinations is further evidence of a gradation of structural changes between them. It could be related to the higher proportion of VFDs in PICCs. The predominant distribution of PICCs infero-temporally supports PICC as a cause of uncertainty in glaucoma diagnosis in high myopia. Furthermore, the highest proportion of PICCs and LCDs in this sector highlights its vulnerability to damage in myopic eyes and deserves further investigation as it is also primarily involved in glaucoma.Keywords: peripapillary intrachoroidal cavitation, visual field defects, peripapillary staphyloma, gamma peripapillary atrophy, ovality index, lamina cribrosa defects, glaucoma, myopic complicationshttps://www.dovepress.com/myopic-peripapillary-changes-and-visual-field-defects-peer-reviewed-fulltext-article-OPTHperipapillary intrachoroidal cavitationvisual field defectsperipapillary staphylomagamma peripapillary atrophyovality indexlamina cribrosa defectsglaucomamyopic complications. |
| spellingShingle | Ehongo A Dugauquier A Kisma N De Maertelaer V Nana Wandji B Tchatchou Tomy W Alaoui Mhammedi Y Coppens K Leroy K Bremer F Myopic (Peri)papillary Changes and Visual Field Defects Clinical Ophthalmology peripapillary intrachoroidal cavitation visual field defects peripapillary staphyloma gamma peripapillary atrophy ovality index lamina cribrosa defects glaucoma myopic complications. |
| title | Myopic (Peri)papillary Changes and Visual Field Defects |
| title_full | Myopic (Peri)papillary Changes and Visual Field Defects |
| title_fullStr | Myopic (Peri)papillary Changes and Visual Field Defects |
| title_full_unstemmed | Myopic (Peri)papillary Changes and Visual Field Defects |
| title_short | Myopic (Peri)papillary Changes and Visual Field Defects |
| title_sort | myopic peri papillary changes and visual field defects |
| topic | peripapillary intrachoroidal cavitation visual field defects peripapillary staphyloma gamma peripapillary atrophy ovality index lamina cribrosa defects glaucoma myopic complications. |
| url | https://www.dovepress.com/myopic-peripapillary-changes-and-visual-field-defects-peer-reviewed-fulltext-article-OPTH |
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