Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) (PHBV)/MBGN Composite Microspheres
In recent years, composite biomaterials have attracted attention for drug delivery applications due to the possibility of combining desired properties of their components. However, some functional characteristics, such as their drug release efficiency and likely side effects, are still unexplored. I...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/15/11/2432 |
| _version_ | 1797596953528238080 |
|---|---|
| author | Arturo E. Aguilar-Rabiela Shahin Homaeigohar Eduin I. González-Castillo Mirna L. Sánchez Aldo R. Boccaccini |
| author_facet | Arturo E. Aguilar-Rabiela Shahin Homaeigohar Eduin I. González-Castillo Mirna L. Sánchez Aldo R. Boccaccini |
| author_sort | Arturo E. Aguilar-Rabiela |
| collection | DOAJ |
| description | In recent years, composite biomaterials have attracted attention for drug delivery applications due to the possibility of combining desired properties of their components. However, some functional characteristics, such as their drug release efficiency and likely side effects, are still unexplored. In this regard, controlled tuning of the drug release kinetic via the precise design of a composite particle system is still of high importance for many biomedical applications. This objective can be properly fulfilled through the combination of different biomaterials with unequal release rates, such as mesoporous bioactive glass nanoparticles (MBGN) and poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) (PHBV) microspheres. In this work, MBGNs and PHBV-MBGN microspheres, both loaded with Astaxanthin (ASX), were synthesised and compared in terms of ASX release kinetic, ASX entrapment efficiency, and cell viability. Moreover, the correlation of the release kinetic to phytotherapeutic efficiency and side effects was established. Interestingly, there were significant differences between the ASX release kinetic of the developed systems, and cell viability differed accordingly after 72 h. Both particle carriers effectively delivered ASX, though the composite microspheres exhibited a more prolonged release profile with sustained cytocompatibility. The release behaviour could be fine-tuned by adjusting the MBGN content in the composite particles. Comparatively, the composite particles induced a different release effect, implying their potential for sustained drug delivery applications. |
| first_indexed | 2024-03-11T02:58:59Z |
| format | Article |
| id | doaj.art-cb03701f38374c8094d151f775a6661e |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T02:58:59Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-cb03701f38374c8094d151f775a6661e2023-11-18T08:25:24ZengMDPI AGPolymers2073-43602023-05-011511243210.3390/polym15112432Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) (PHBV)/MBGN Composite MicrospheresArturo E. Aguilar-Rabiela0Shahin Homaeigohar1Eduin I. González-Castillo2Mirna L. Sánchez3Aldo R. Boccaccini4Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, GermanySchool of Science & Engineering, University of Dundee, Dundee DD1 4HN, UKPolymer Institute, Slovak Academy of Sciences, Dúbravská Cesta 9, 845 41 Bratislava, SlovakiaInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, GermanyInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, GermanyIn recent years, composite biomaterials have attracted attention for drug delivery applications due to the possibility of combining desired properties of their components. However, some functional characteristics, such as their drug release efficiency and likely side effects, are still unexplored. In this regard, controlled tuning of the drug release kinetic via the precise design of a composite particle system is still of high importance for many biomedical applications. This objective can be properly fulfilled through the combination of different biomaterials with unequal release rates, such as mesoporous bioactive glass nanoparticles (MBGN) and poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) (PHBV) microspheres. In this work, MBGNs and PHBV-MBGN microspheres, both loaded with Astaxanthin (ASX), were synthesised and compared in terms of ASX release kinetic, ASX entrapment efficiency, and cell viability. Moreover, the correlation of the release kinetic to phytotherapeutic efficiency and side effects was established. Interestingly, there were significant differences between the ASX release kinetic of the developed systems, and cell viability differed accordingly after 72 h. Both particle carriers effectively delivered ASX, though the composite microspheres exhibited a more prolonged release profile with sustained cytocompatibility. The release behaviour could be fine-tuned by adjusting the MBGN content in the composite particles. Comparatively, the composite particles induced a different release effect, implying their potential for sustained drug delivery applications.https://www.mdpi.com/2073-4360/15/11/2432Astaxanthincomposite microspheressustained releasecontrolled release |
| spellingShingle | Arturo E. Aguilar-Rabiela Shahin Homaeigohar Eduin I. González-Castillo Mirna L. Sánchez Aldo R. Boccaccini Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) (PHBV)/MBGN Composite Microspheres Polymers Astaxanthin composite microspheres sustained release controlled release |
| title | Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) (PHBV)/MBGN Composite Microspheres |
| title_full | Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) (PHBV)/MBGN Composite Microspheres |
| title_fullStr | Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) (PHBV)/MBGN Composite Microspheres |
| title_full_unstemmed | Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) (PHBV)/MBGN Composite Microspheres |
| title_short | Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) (PHBV)/MBGN Composite Microspheres |
| title_sort | comparison between the astaxanthin release profile of mesoporous bioactive glass nanoparticles mbgns and poly 3 hydroxybutyrate i co i 3 hydroxyvalerate phbv mbgn composite microspheres |
| topic | Astaxanthin composite microspheres sustained release controlled release |
| url | https://www.mdpi.com/2073-4360/15/11/2432 |
| work_keys_str_mv | AT arturoeaguilarrabiela comparisonbetweentheastaxanthinreleaseprofileofmesoporousbioactiveglassnanoparticlesmbgnsandpoly3hydroxybutyrateicoi3hydroxyvaleratephbvmbgncompositemicrospheres AT shahinhomaeigohar comparisonbetweentheastaxanthinreleaseprofileofmesoporousbioactiveglassnanoparticlesmbgnsandpoly3hydroxybutyrateicoi3hydroxyvaleratephbvmbgncompositemicrospheres AT eduinigonzalezcastillo comparisonbetweentheastaxanthinreleaseprofileofmesoporousbioactiveglassnanoparticlesmbgnsandpoly3hydroxybutyrateicoi3hydroxyvaleratephbvmbgncompositemicrospheres AT mirnalsanchez comparisonbetweentheastaxanthinreleaseprofileofmesoporousbioactiveglassnanoparticlesmbgnsandpoly3hydroxybutyrateicoi3hydroxyvaleratephbvmbgncompositemicrospheres AT aldorboccaccini comparisonbetweentheastaxanthinreleaseprofileofmesoporousbioactiveglassnanoparticlesmbgnsandpoly3hydroxybutyrateicoi3hydroxyvaleratephbvmbgncompositemicrospheres |