Body composition and metabolic consequences of antibiotics most frequently administered to newborns in intensive care units: an experimental study in healthy newborn rats
IntroductionThe increasing overuse of antibiotics in recent years has led to antibiotics being the most prescribed drugs for pediatric patients, and 72% of patients in the neonatal intensive care unit are treated with antibiotics. One effect of antibiotic use is the alteration of the microbiota, whi...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1369797/full |
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| author | Enrique Segura-Cervantes Javier Mancilla-Ramírez Liliana Fernández-Urrutia Susana González-Gallardo Lourdes Mendoza-Gertrudis Jasibe Valencia-Santaella Norma Galindo-Sevilla |
| author_facet | Enrique Segura-Cervantes Javier Mancilla-Ramírez Liliana Fernández-Urrutia Susana González-Gallardo Lourdes Mendoza-Gertrudis Jasibe Valencia-Santaella Norma Galindo-Sevilla |
| author_sort | Enrique Segura-Cervantes |
| collection | DOAJ |
| description | IntroductionThe increasing overuse of antibiotics in recent years has led to antibiotics being the most prescribed drugs for pediatric patients, and 72% of patients in the neonatal intensive care unit are treated with antibiotics. One effect of antibiotic use is the alteration of the microbiota, which is associated with metabolic disorders, including obesity.MethodsThis experimental study in newborn rats compared the administration of ampicillin/meropenem (Access/Watch groups) at 100/10 μg/g every 12 h, cefotaxime 200 μg/g every 24 h (Watch group), and amikacin 15 μg/g every 24 h (Access group) versus saline solution as the control. Each antibiotic was adjusted to the required dosages based on weight, and the doses were administered intraperitoneally daily for 5 days to 10–14 newborn male rats per group. A comparison of the morphometric and biochemical parameters registered on day 28 was performed using ANOVA.ResultsAmikacin had the largest effect on morphometric measurements, and low-density lipoprotein cholesterol, while cefotaxime had the largest effect on glucose and triglycerides, whereas ampicillin/meropenem produced the weakest effect on the measured parameters.DiscussionThe administration of antibiotics in the neonatal stage can affect the body composition of rats as well as the lipid and carbohydrate serum levels. Future studies should evaluate the toxicity of antibiotics in immature neonatal organs and could help to improve therapeutic decisions and prevent the unjustified use of antibiotics in newborns, thereby reducing metabolic consequences. |
| first_indexed | 2024-04-24T06:30:33Z |
| format | Article |
| id | doaj.art-cb0384d7709a4049ae11b1afadad39b0 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-24T06:30:33Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-cb0384d7709a4049ae11b1afadad39b02024-04-23T04:38:20ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-04-011110.3389/fmed.2024.13697971369797Body composition and metabolic consequences of antibiotics most frequently administered to newborns in intensive care units: an experimental study in healthy newborn ratsEnrique Segura-Cervantes0Javier Mancilla-Ramírez1Liliana Fernández-Urrutia2Susana González-Gallardo3Lourdes Mendoza-Gertrudis4Jasibe Valencia-Santaella5Norma Galindo-Sevilla6Departamento de Epidemiología, Instituto Nacional de Perinatología, Mexico City, MexicoEscuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, MexicoSt. Luke Escuela de Medicina, Mexico City, MexicoDepartamento de Patología, Instituto Nacional de Perinatología, Mexico City, MexicoEscuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, MexicoEscuela de Medicina, Universidad Anáhuac, Oaxaca, MexicoDepartamento de Infectología e Inmunología, Instituto Nacional de Perinatología, Secretaría de Salud, Mexico City, MexicoIntroductionThe increasing overuse of antibiotics in recent years has led to antibiotics being the most prescribed drugs for pediatric patients, and 72% of patients in the neonatal intensive care unit are treated with antibiotics. One effect of antibiotic use is the alteration of the microbiota, which is associated with metabolic disorders, including obesity.MethodsThis experimental study in newborn rats compared the administration of ampicillin/meropenem (Access/Watch groups) at 100/10 μg/g every 12 h, cefotaxime 200 μg/g every 24 h (Watch group), and amikacin 15 μg/g every 24 h (Access group) versus saline solution as the control. Each antibiotic was adjusted to the required dosages based on weight, and the doses were administered intraperitoneally daily for 5 days to 10–14 newborn male rats per group. A comparison of the morphometric and biochemical parameters registered on day 28 was performed using ANOVA.ResultsAmikacin had the largest effect on morphometric measurements, and low-density lipoprotein cholesterol, while cefotaxime had the largest effect on glucose and triglycerides, whereas ampicillin/meropenem produced the weakest effect on the measured parameters.DiscussionThe administration of antibiotics in the neonatal stage can affect the body composition of rats as well as the lipid and carbohydrate serum levels. Future studies should evaluate the toxicity of antibiotics in immature neonatal organs and could help to improve therapeutic decisions and prevent the unjustified use of antibiotics in newborns, thereby reducing metabolic consequences.https://www.frontiersin.org/articles/10.3389/fmed.2024.1369797/fullantibioticsbody compositionnewbornanimal modelneonate development |
| spellingShingle | Enrique Segura-Cervantes Javier Mancilla-Ramírez Liliana Fernández-Urrutia Susana González-Gallardo Lourdes Mendoza-Gertrudis Jasibe Valencia-Santaella Norma Galindo-Sevilla Body composition and metabolic consequences of antibiotics most frequently administered to newborns in intensive care units: an experimental study in healthy newborn rats Frontiers in Medicine antibiotics body composition newborn animal model neonate development |
| title | Body composition and metabolic consequences of antibiotics most frequently administered to newborns in intensive care units: an experimental study in healthy newborn rats |
| title_full | Body composition and metabolic consequences of antibiotics most frequently administered to newborns in intensive care units: an experimental study in healthy newborn rats |
| title_fullStr | Body composition and metabolic consequences of antibiotics most frequently administered to newborns in intensive care units: an experimental study in healthy newborn rats |
| title_full_unstemmed | Body composition and metabolic consequences of antibiotics most frequently administered to newborns in intensive care units: an experimental study in healthy newborn rats |
| title_short | Body composition and metabolic consequences of antibiotics most frequently administered to newborns in intensive care units: an experimental study in healthy newborn rats |
| title_sort | body composition and metabolic consequences of antibiotics most frequently administered to newborns in intensive care units an experimental study in healthy newborn rats |
| topic | antibiotics body composition newborn animal model neonate development |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1369797/full |
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