Influenza season influence on outcome of new nodules in the NELSON study
Abstract We evaluated the impact of the influenza season on outcome of new lung nodules in a LDCT lung cancer screening trial population. NELSON-trial participants with ≥ 1 new nodule detected in screening rounds two and three were included. Outcome (resolution or persistence) of new nodules detecte...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33672-4 |
| _version_ | 1797841105019994112 |
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| author | H. L. Lancaster M. A. Heuvelmans G. H. de Bock Y. Du F. A. A. Mohamed Hoesein K. Nackaerts J. E. Walter R. Vliegenthart M. Oudkerk |
| author_facet | H. L. Lancaster M. A. Heuvelmans G. H. de Bock Y. Du F. A. A. Mohamed Hoesein K. Nackaerts J. E. Walter R. Vliegenthart M. Oudkerk |
| author_sort | H. L. Lancaster |
| collection | DOAJ |
| description | Abstract We evaluated the impact of the influenza season on outcome of new lung nodules in a LDCT lung cancer screening trial population. NELSON-trial participants with ≥ 1 new nodule detected in screening rounds two and three were included. Outcome (resolution or persistence) of new nodules detected per season was calculated and compared. Winter (influenza season) was defined as 1st October to 31st March, and compared to the summer (hay-fever season), 1st April to 30th September. Overall, 820 new nodules were reported in 529 participants. Of the total new nodules, 482 (59%) were reported during winter. When considering the outcome of all new nodules, there was no statistically significant association between summer and resolving nodules (OR 1.07 [CI 1.00–1.15], p = 0.066), also when looking at the largest nodule per participant (OR 1.37 [CI 0.95–1.98], p = 0.094). Similarly, there was no statistically significant association between season and screen detected cancers (OR 0.47 [CI 0.18–1.23], p = 0.123). To conclude, in this lung cancer screening population, there was no statistically significant association between influenza season and outcome of new lung nodules. Hence, we recommend new nodule management strategy is not influenced by the season in which the nodule is detected. |
| first_indexed | 2024-04-09T16:25:37Z |
| format | Article |
| id | doaj.art-cb0671c8b78a4f53bec2b005956bedb1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T16:25:37Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-cb0671c8b78a4f53bec2b005956bedb12023-04-23T11:16:38ZengNature PortfolioScientific Reports2045-23222023-04-011311810.1038/s41598-023-33672-4Influenza season influence on outcome of new nodules in the NELSON studyH. L. Lancaster0M. A. Heuvelmans1G. H. de Bock2Y. Du3F. A. A. Mohamed Hoesein4K. Nackaerts5J. E. Walter6R. Vliegenthart7M. Oudkerk8Department of Epidemiology, University of Groningen, University Medical Center GroningenDepartment of Epidemiology, University of Groningen, University Medical Center GroningenDepartment of Epidemiology, University of Groningen, University Medical Center GroningenDepartment of Epidemiology, University of Groningen, University Medical Center GroningenDepartment of Radiology, University Medical Center Utrecht, Utrecht UniversityDepartment of Pneumology, University Hospital Leuven, KU LeuvenDepartment of Medical Oncology and Hematology, University Hospital ZurichDepartment of Radiology, University of Groningen, University Medical Center GroningenFaculty of Medical Sciences, University of GroningenAbstract We evaluated the impact of the influenza season on outcome of new lung nodules in a LDCT lung cancer screening trial population. NELSON-trial participants with ≥ 1 new nodule detected in screening rounds two and three were included. Outcome (resolution or persistence) of new nodules detected per season was calculated and compared. Winter (influenza season) was defined as 1st October to 31st March, and compared to the summer (hay-fever season), 1st April to 30th September. Overall, 820 new nodules were reported in 529 participants. Of the total new nodules, 482 (59%) were reported during winter. When considering the outcome of all new nodules, there was no statistically significant association between summer and resolving nodules (OR 1.07 [CI 1.00–1.15], p = 0.066), also when looking at the largest nodule per participant (OR 1.37 [CI 0.95–1.98], p = 0.094). Similarly, there was no statistically significant association between season and screen detected cancers (OR 0.47 [CI 0.18–1.23], p = 0.123). To conclude, in this lung cancer screening population, there was no statistically significant association between influenza season and outcome of new lung nodules. Hence, we recommend new nodule management strategy is not influenced by the season in which the nodule is detected.https://doi.org/10.1038/s41598-023-33672-4 |
| spellingShingle | H. L. Lancaster M. A. Heuvelmans G. H. de Bock Y. Du F. A. A. Mohamed Hoesein K. Nackaerts J. E. Walter R. Vliegenthart M. Oudkerk Influenza season influence on outcome of new nodules in the NELSON study Scientific Reports |
| title | Influenza season influence on outcome of new nodules in the NELSON study |
| title_full | Influenza season influence on outcome of new nodules in the NELSON study |
| title_fullStr | Influenza season influence on outcome of new nodules in the NELSON study |
| title_full_unstemmed | Influenza season influence on outcome of new nodules in the NELSON study |
| title_short | Influenza season influence on outcome of new nodules in the NELSON study |
| title_sort | influenza season influence on outcome of new nodules in the nelson study |
| url | https://doi.org/10.1038/s41598-023-33672-4 |
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