A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis
Treponema pallidum subsp. pallidum is the causative agent of syphilis, a sexually transmitted disease with worldwide prevalence. Several different molecular typing schemes are currently available for this pathogen. To enable population biology studies of the syphilis agent and for epidemiological su...
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PeerJ Inc.
2019-01-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/6182.pdf |
| _version_ | 1827612131815587840 |
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| author | Linda Grillova Keith Jolley David Šmajs Mathieu Picardeau |
| author_facet | Linda Grillova Keith Jolley David Šmajs Mathieu Picardeau |
| author_sort | Linda Grillova |
| collection | DOAJ |
| description | Treponema pallidum subsp. pallidum is the causative agent of syphilis, a sexually transmitted disease with worldwide prevalence. Several different molecular typing schemes are currently available for this pathogen. To enable population biology studies of the syphilis agent and for epidemiological surveillance at the global scale, a harmonized typing tool needs to be introduced. Recently, we published a new multi-locus sequence typing (MLST) with the potential to significantly enhance the epidemiological data in several aspects (e.g., distinguishing genetically different clades of syphilis, subtyping inside these clades, and finally, distinguishing different subspecies of non-cultivable pathogenic treponemes). In this short report, we introduce the PubMLST database for treponemal DNA data storage and for assignments of allelic profiles and sequencing types. Moreover, we have summarized epidemiological data of all treponemal strains (n = 358) with available DNA sequences in typing loci and found several association between genetic groups and characteristics of patients. This study proposes the establishment of a single MLST of T. p. pallidum and encourages researchers and public health communities to use this PubMLST database as a universal tool for molecular typing studies of the syphilis pathogen. |
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| id | doaj.art-cb06cdd470e74e0d887495ffb2a61b5b |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T08:17:02Z |
| publishDate | 2019-01-01 |
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| spelling | doaj.art-cb06cdd470e74e0d887495ffb2a61b5b2023-12-02T22:01:45ZengPeerJ Inc.PeerJ2167-83592019-01-016e618210.7717/peerj.6182A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilisLinda Grillova0Keith Jolley1David Šmajs2Mathieu Picardeau3Biology of Spirochetes Unit, Institut Pasteur, Paris, FranceDepartment of Zoology, University of Oxford, Oxford, UKDepartment of Biology, Masaryk University, Brno, Czech RepublicBiology of Spirochetes Unit, Institut Pasteur, Paris, FranceTreponema pallidum subsp. pallidum is the causative agent of syphilis, a sexually transmitted disease with worldwide prevalence. Several different molecular typing schemes are currently available for this pathogen. To enable population biology studies of the syphilis agent and for epidemiological surveillance at the global scale, a harmonized typing tool needs to be introduced. Recently, we published a new multi-locus sequence typing (MLST) with the potential to significantly enhance the epidemiological data in several aspects (e.g., distinguishing genetically different clades of syphilis, subtyping inside these clades, and finally, distinguishing different subspecies of non-cultivable pathogenic treponemes). In this short report, we introduce the PubMLST database for treponemal DNA data storage and for assignments of allelic profiles and sequencing types. Moreover, we have summarized epidemiological data of all treponemal strains (n = 358) with available DNA sequences in typing loci and found several association between genetic groups and characteristics of patients. This study proposes the establishment of a single MLST of T. p. pallidum and encourages researchers and public health communities to use this PubMLST database as a universal tool for molecular typing studies of the syphilis pathogen.https://peerj.com/articles/6182.pdfTreponema pallidum subsp. pallidumMolecular typingPubMLST |
| spellingShingle | Linda Grillova Keith Jolley David Šmajs Mathieu Picardeau A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis PeerJ Treponema pallidum subsp. pallidum Molecular typing PubMLST |
| title | A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis |
| title_full | A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis |
| title_fullStr | A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis |
| title_full_unstemmed | A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis |
| title_short | A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis |
| title_sort | public database for the new mlst scheme for treponema pallidum subsp pallidum surveillance and epidemiology of the causative agent of syphilis |
| topic | Treponema pallidum subsp. pallidum Molecular typing PubMLST |
| url | https://peerj.com/articles/6182.pdf |
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