Soluble mannose receptor CD206 and von Willebrand factor are early biomarkers to identify patients at risk for severe or necrotizing acute pancreatitis

Soluble mannose receptor CD206 and von Willebrand factor are early biomarkers to identify patients at risk for severe or necrotizing acute pancreatitis

Abstract Background In acute pancreatitis (AP), microcirculatory dysfunction and leukocyte activation contribute to organ damage, inflammation, and mortality. Given the role of macrophage activation, monocyte recruitment, and microthrombus formation in the early pathogenesis of AP, we examined the m...

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Bibliographic Details
Main Authors: Philipp A. Reuken, Jonathan F. Brozat, Stefanie Quickert, Oluwatomi Ibidapo-obe, Johanna Reißing, Anika Franz, Sven Stengel, Ulf K.-M. Teichgräber, Michael Kiehntopf, Christian Trautwein, Andreas Stallmach, Alexander Koch, Tony Bruns
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Intensive Care
Subjects:
Acute pancreatitis
Necrotizing pancreatitis
Endothelial activation
Macrophage activation
Online Access:https://doi.org/10.1186/s40560-022-00619-2

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