RIF1 promotes replication fork protection and efficient restart to maintain genome stability
Replication fork degradation can result in genome instability. Here authors reveal a role for Rif1 protein in protecting stalled replication forks from undergoing extensive, DNA2-dependent, degradation.
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11246-1 |
| _version_ | 1818839601526079488 |
|---|---|
| author | Chirantani Mukherjee Vivek Tripathi Eleni Maria Manolika Anne Margriet Heijink Giulia Ricci Sarra Merzouk H. Rudolf de Boer Jeroen Demmers Marcel A. T. M. van Vugt Arnab Ray Chaudhuri |
| author_facet | Chirantani Mukherjee Vivek Tripathi Eleni Maria Manolika Anne Margriet Heijink Giulia Ricci Sarra Merzouk H. Rudolf de Boer Jeroen Demmers Marcel A. T. M. van Vugt Arnab Ray Chaudhuri |
| author_sort | Chirantani Mukherjee |
| collection | DOAJ |
| description | Replication fork degradation can result in genome instability. Here authors reveal a role for Rif1 protein in protecting stalled replication forks from undergoing extensive, DNA2-dependent, degradation. |
| first_indexed | 2024-12-19T03:56:53Z |
| format | Article |
| id | doaj.art-cb070f743a7d4af79f8d12d89e2dfee4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T03:56:53Z |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cb070f743a7d4af79f8d12d89e2dfee42022-12-21T20:36:48ZengNature PortfolioNature Communications2041-17232019-07-0110111610.1038/s41467-019-11246-1RIF1 promotes replication fork protection and efficient restart to maintain genome stabilityChirantani Mukherjee0Vivek Tripathi1Eleni Maria Manolika2Anne Margriet Heijink3Giulia Ricci4Sarra Merzouk5H. Rudolf de Boer6Jeroen Demmers7Marcel A. T. M. van Vugt8Arnab Ray Chaudhuri9Department of Molecular Genetics, Erasmus University Medical CenterDepartment of Molecular Genetics, Erasmus University Medical CenterDepartment of Molecular Genetics, Erasmus University Medical CenterDepartment of Medical Oncology, University Medical Center Groningen, University of GroningenDepartment of Molecular Genetics, Erasmus University Medical CenterDepartment of Developmental Biology, Erasmus University Medical CenterDepartment of Medical Oncology, University Medical Center Groningen, University of GroningenDepartment of Biochemistry, Erasmus University Medical CenterDepartment of Medical Oncology, University Medical Center Groningen, University of GroningenDepartment of Molecular Genetics, Erasmus University Medical CenterReplication fork degradation can result in genome instability. Here authors reveal a role for Rif1 protein in protecting stalled replication forks from undergoing extensive, DNA2-dependent, degradation.https://doi.org/10.1038/s41467-019-11246-1 |
| spellingShingle | Chirantani Mukherjee Vivek Tripathi Eleni Maria Manolika Anne Margriet Heijink Giulia Ricci Sarra Merzouk H. Rudolf de Boer Jeroen Demmers Marcel A. T. M. van Vugt Arnab Ray Chaudhuri RIF1 promotes replication fork protection and efficient restart to maintain genome stability Nature Communications |
| title | RIF1 promotes replication fork protection and efficient restart to maintain genome stability |
| title_full | RIF1 promotes replication fork protection and efficient restart to maintain genome stability |
| title_fullStr | RIF1 promotes replication fork protection and efficient restart to maintain genome stability |
| title_full_unstemmed | RIF1 promotes replication fork protection and efficient restart to maintain genome stability |
| title_short | RIF1 promotes replication fork protection and efficient restart to maintain genome stability |
| title_sort | rif1 promotes replication fork protection and efficient restart to maintain genome stability |
| url | https://doi.org/10.1038/s41467-019-11246-1 |
| work_keys_str_mv | AT chirantanimukherjee rif1promotesreplicationforkprotectionandefficientrestarttomaintaingenomestability AT vivektripathi rif1promotesreplicationforkprotectionandefficientrestarttomaintaingenomestability AT elenimariamanolika rif1promotesreplicationforkprotectionandefficientrestarttomaintaingenomestability AT annemargrietheijink rif1promotesreplicationforkprotectionandefficientrestarttomaintaingenomestability AT giuliaricci rif1promotesreplicationforkprotectionandefficientrestarttomaintaingenomestability AT sarramerzouk rif1promotesreplicationforkprotectionandefficientrestarttomaintaingenomestability AT hrudolfdeboer rif1promotesreplicationforkprotectionandefficientrestarttomaintaingenomestability AT jeroendemmers rif1promotesreplicationforkprotectionandefficientrestarttomaintaingenomestability AT marcelatmvanvugt rif1promotesreplicationforkprotectionandefficientrestarttomaintaingenomestability AT arnabraychaudhuri rif1promotesreplicationforkprotectionandefficientrestarttomaintaingenomestability |