Three functional facets of Calbindin D-28k
Many neurons of the vertebrate central nervous system (CNS) express the Ca2+ binding protein calbindin D-28k (CB), including important projection neurons like cerebellar Purkinje cells but also neocortical interneurons. CB has moderate cytoplasmic mobility and comprises at least four EF-hands that f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-03-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00025/full |
| _version_ | 1818140662741073920 |
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| author | Hartmut eSchmidt |
| author_facet | Hartmut eSchmidt |
| author_sort | Hartmut eSchmidt |
| collection | DOAJ |
| description | Many neurons of the vertebrate central nervous system (CNS) express the Ca2+ binding protein calbindin D-28k (CB), including important projection neurons like cerebellar Purkinje cells but also neocortical interneurons. CB has moderate cytoplasmic mobility and comprises at least four EF-hands that function in Ca2+ binding with rapid to intermediate kinetics and affinity. Classically it was viewed as a pure Ca2+ buffer important for neuronal survival. This view was extended by showing that CB is a critical determinant in the control of synaptic Ca2+ dynamics, presumably with strong impact on plasticity and information processing. Already 30 years ago, in vitro studies suggested that CB could have an additional Ca2+ sensor function, like its prominent acquaintance calmodulin (CaM). More recent work substantiated this hypothesis, revealing direct CB interactions with several target proteins. Different from a classical sensor, however, CB appears to interact with its targets both, in its Ca2+-loaded and Ca2+-free forms. Finally, CB has been shown to be involved in buffered transport of Ca2+, in neurons but also in kidney. Thus, CB serves a threefold function as buffer, transporter and likely as a non-canonical sensor. |
| first_indexed | 2024-12-11T10:47:33Z |
| format | Article |
| id | doaj.art-cb0773b65e4645aaafd8012ea5db4b1a |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-11T10:47:33Z |
| publishDate | 2012-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-cb0773b65e4645aaafd8012ea5db4b1a2022-12-22T01:10:25ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992012-03-01510.3389/fnmol.2012.0002522191Three functional facets of Calbindin D-28kHartmut eSchmidt0University of Leipzig, Carl-Ludwig-Institute for Physiology, Medical FacultyMany neurons of the vertebrate central nervous system (CNS) express the Ca2+ binding protein calbindin D-28k (CB), including important projection neurons like cerebellar Purkinje cells but also neocortical interneurons. CB has moderate cytoplasmic mobility and comprises at least four EF-hands that function in Ca2+ binding with rapid to intermediate kinetics and affinity. Classically it was viewed as a pure Ca2+ buffer important for neuronal survival. This view was extended by showing that CB is a critical determinant in the control of synaptic Ca2+ dynamics, presumably with strong impact on plasticity and information processing. Already 30 years ago, in vitro studies suggested that CB could have an additional Ca2+ sensor function, like its prominent acquaintance calmodulin (CaM). More recent work substantiated this hypothesis, revealing direct CB interactions with several target proteins. Different from a classical sensor, however, CB appears to interact with its targets both, in its Ca2+-loaded and Ca2+-free forms. Finally, CB has been shown to be involved in buffered transport of Ca2+, in neurons but also in kidney. Thus, CB serves a threefold function as buffer, transporter and likely as a non-canonical sensor.http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00025/fullCalciumNeuronssynaptic plasticitytransporterSensortransmitter release |
| spellingShingle | Hartmut eSchmidt Three functional facets of Calbindin D-28k Frontiers in Molecular Neuroscience Calcium Neurons synaptic plasticity transporter Sensor transmitter release |
| title | Three functional facets of Calbindin D-28k |
| title_full | Three functional facets of Calbindin D-28k |
| title_fullStr | Three functional facets of Calbindin D-28k |
| title_full_unstemmed | Three functional facets of Calbindin D-28k |
| title_short | Three functional facets of Calbindin D-28k |
| title_sort | three functional facets of calbindin d 28k |
| topic | Calcium Neurons synaptic plasticity transporter Sensor transmitter release |
| url | http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00025/full |
| work_keys_str_mv | AT hartmuteschmidt threefunctionalfacetsofcalbindind28k |