Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
Abstract Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood. Here we show that lipotoxicity increased histone deacetylase 4 (HDAC4) and histone deacetyla...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2023-12-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-023-06319-5 |