Synthesis and pharmacological screening of 4, 6-substituted di-(phenyl) pyrimidin-2-amines
A new series of 4, 6-substituted di-(phenyl) pyrimidin-2-amine (IIa–d) were synthesized by reacting chalcone derivatives with guanidine hydrochloride in the presence of dimethylformamide. The synthesized compounds were characterized by spectral analysis and were screened for anti-inflammatory activi...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535212003140 |
| _version_ | 1828347107359064064 |
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| author | Nitin Kumar Sushma Drabu Kumari Shalini |
| author_facet | Nitin Kumar Sushma Drabu Kumari Shalini |
| author_sort | Nitin Kumar |
| collection | DOAJ |
| description | A new series of 4, 6-substituted di-(phenyl) pyrimidin-2-amine (IIa–d) were synthesized by reacting chalcone derivatives with guanidine hydrochloride in the presence of dimethylformamide. The synthesized compounds were characterized by spectral analysis and were screened for anti-inflammatory activity. Two compounds 4-(4-nitrophenyl)-6-phenylpyrimidine-2-amine (IIa) and 4-(4-methoxyphenyl)-6-phenylpyrimidine-2-amine (IIb) showed highly significant reduction in oedema volume |
| first_indexed | 2024-04-14T00:36:13Z |
| format | Article |
| id | doaj.art-cb09a8776a1b4682bebac02e05c4d9d1 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-14T00:36:13Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-cb09a8776a1b4682bebac02e05c4d9d12022-12-22T02:22:23ZengElsevierArabian Journal of Chemistry1878-53522017-02-0110S1S877S88010.1016/j.arabjc.2012.12.023Synthesis and pharmacological screening of 4, 6-substituted di-(phenyl) pyrimidin-2-aminesNitin Kumar0Sushma Drabu1Kumari Shalini2Department of Pharmaceutical Technology, MIET, NH-58, Bypass Road, Baghpat Crossing, Meerut-250005, U.P., IndiaMaharaja Surajmal Institute of Pharmacy C-4, Janakpuri, New Delhi-58, IndiaDepartment of Pharmaceutical Technology, MIET, NH-58, Bypass Road, Baghpat Crossing, Meerut-250005, U.P., IndiaA new series of 4, 6-substituted di-(phenyl) pyrimidin-2-amine (IIa–d) were synthesized by reacting chalcone derivatives with guanidine hydrochloride in the presence of dimethylformamide. The synthesized compounds were characterized by spectral analysis and were screened for anti-inflammatory activity. Two compounds 4-(4-nitrophenyl)-6-phenylpyrimidine-2-amine (IIa) and 4-(4-methoxyphenyl)-6-phenylpyrimidine-2-amine (IIb) showed highly significant reduction in oedema volumehttp://www.sciencedirect.com/science/article/pii/S1878535212003140PyrimidineChalconeAnti-inflammatory activity |
| spellingShingle | Nitin Kumar Sushma Drabu Kumari Shalini Synthesis and pharmacological screening of 4, 6-substituted di-(phenyl) pyrimidin-2-amines Arabian Journal of Chemistry Pyrimidine Chalcone Anti-inflammatory activity |
| title | Synthesis and pharmacological screening of 4, 6-substituted di-(phenyl) pyrimidin-2-amines |
| title_full | Synthesis and pharmacological screening of 4, 6-substituted di-(phenyl) pyrimidin-2-amines |
| title_fullStr | Synthesis and pharmacological screening of 4, 6-substituted di-(phenyl) pyrimidin-2-amines |
| title_full_unstemmed | Synthesis and pharmacological screening of 4, 6-substituted di-(phenyl) pyrimidin-2-amines |
| title_short | Synthesis and pharmacological screening of 4, 6-substituted di-(phenyl) pyrimidin-2-amines |
| title_sort | synthesis and pharmacological screening of 4 6 substituted di phenyl pyrimidin 2 amines |
| topic | Pyrimidine Chalcone Anti-inflammatory activity |
| url | http://www.sciencedirect.com/science/article/pii/S1878535212003140 |
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