Hematologic and laboratory parameters in patientis with peptic ulcer bleeding treated by two modalities of endoscopic haemostasis and proton pompe inhibitors
Aim To compare two schedules (continuous infusion or bolus iv. ofPPI) in treatment after endoscopic homeostasis of bleeding ulcers. Methods Patients with gastrointestinal bleeding caused by peptic ulcer, or a recent history (<24 h before presentation) were included in the study. All cases with ac...
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Medical Association of Zenica-Doboj Canton
2011-02-01
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| Series: | Medicinski Glasnik |
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| Online Access: | http://www.ljkzedo.com.ba/medglasnik/vol81/MGvol81.2011_29.pdf |
| _version_ | 1828487807624019968 |
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| author | Amila Mehmedović-Redžepović Rusmir Mesihović Besim Prnjavorac Aida Kulo Kalajdžija Merlina |
| author_facet | Amila Mehmedović-Redžepović Rusmir Mesihović Besim Prnjavorac Aida Kulo Kalajdžija Merlina |
| author_sort | Amila Mehmedović-Redžepović |
| collection | DOAJ |
| description | Aim To compare two schedules (continuous infusion or bolus iv. ofPPI) in treatment after endoscopic homeostasis of bleeding ulcers. Methods Patients with gastrointestinal bleeding caused by peptic ulcer, or a recent history (<24 h before presentation) were included in the study. All cases with actively bleeding ulcers were treated with epinephrine injection and/or thermal coagulation, and randomized to receive intravenous PPIs according to the continuousregimen (in continuous infusion) or the standard regimen (40 mg bolus twice a day for 3 days). Results 69 patients were treated. Bleeding recurred in 5 of 34 patients (14.7%) receiving the intensive regimen, and in 8 of 35 (22.8%) patients receiving the standard regimen. Hemoglobine rate in standard regimen group was 93,5 g/L (SD 23,8), and in intensive regimen group 106,6 g/L (SD 22,4) (p = 0.042). Total protein rate in the standard regimen group was 65,1 g/L (SD 7,3) and in the intensive regimen group 67,7 g/L (SD 8,15), (p = 0.525). Albumin rate in the standard regimen group was 31,0 g/L (SD 5,2), whereas in the intensive regimen group it was 34,8 g/L (SD 7,4), (p = 0.652). Globulin rate in the standard regimen group was 31,0 g/L (SD 5,2) and in the intensive regimen group 32,3 g/L (5,3), (p = 0.875). Fibrinogen rate in the standard regimen group was 11,1 (SD 2,6) and 10,8 g/L (SD 2,4 p = 0.622) in the intensive regimen group. A mean number of units of blood transfusion for patients in the intensive group was 2,18 (SD 0,8) and 1,34 (SD 1,02) in the standard group, with statistical level of difference p = 0.0004, using Student t-test. The duration of hospital stay was 6,4 days (SD 2,8) in the standard group and 5,8 days (SD 2,8) in the intensive group (p = 0.40). There were fewer surgical interventions in the intensive versus standard regimen.Conclusion In patients with bleeding peptic ulcers with successfulendoscopic hemostasis the standard IPP regimen had advantage for transfusion requirements, but no advantage with respect to inhospital rates of re-bleeding, need for surgery, length of hospitalstay, or death. |
| first_indexed | 2024-12-11T09:57:33Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1840-0132 1840-2445 |
| language | English |
| last_indexed | 2024-12-11T09:57:33Z |
| publishDate | 2011-02-01 |
| publisher | Medical Association of Zenica-Doboj Canton |
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| series | Medicinski Glasnik |
| spelling | doaj.art-cb0a06929cec471493102de551b069cb2022-12-22T01:12:13ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452011-02-0181151157Hematologic and laboratory parameters in patientis with peptic ulcer bleeding treated by two modalities of endoscopic haemostasis and proton pompe inhibitorsAmila Mehmedović-RedžepovićRusmir MesihovićBesim PrnjavoracAida KuloKalajdžija MerlinaAim To compare two schedules (continuous infusion or bolus iv. ofPPI) in treatment after endoscopic homeostasis of bleeding ulcers. Methods Patients with gastrointestinal bleeding caused by peptic ulcer, or a recent history (<24 h before presentation) were included in the study. All cases with actively bleeding ulcers were treated with epinephrine injection and/or thermal coagulation, and randomized to receive intravenous PPIs according to the continuousregimen (in continuous infusion) or the standard regimen (40 mg bolus twice a day for 3 days). Results 69 patients were treated. Bleeding recurred in 5 of 34 patients (14.7%) receiving the intensive regimen, and in 8 of 35 (22.8%) patients receiving the standard regimen. Hemoglobine rate in standard regimen group was 93,5 g/L (SD 23,8), and in intensive regimen group 106,6 g/L (SD 22,4) (p = 0.042). Total protein rate in the standard regimen group was 65,1 g/L (SD 7,3) and in the intensive regimen group 67,7 g/L (SD 8,15), (p = 0.525). Albumin rate in the standard regimen group was 31,0 g/L (SD 5,2), whereas in the intensive regimen group it was 34,8 g/L (SD 7,4), (p = 0.652). Globulin rate in the standard regimen group was 31,0 g/L (SD 5,2) and in the intensive regimen group 32,3 g/L (5,3), (p = 0.875). Fibrinogen rate in the standard regimen group was 11,1 (SD 2,6) and 10,8 g/L (SD 2,4 p = 0.622) in the intensive regimen group. A mean number of units of blood transfusion for patients in the intensive group was 2,18 (SD 0,8) and 1,34 (SD 1,02) in the standard group, with statistical level of difference p = 0.0004, using Student t-test. The duration of hospital stay was 6,4 days (SD 2,8) in the standard group and 5,8 days (SD 2,8) in the intensive group (p = 0.40). There were fewer surgical interventions in the intensive versus standard regimen.Conclusion In patients with bleeding peptic ulcers with successfulendoscopic hemostasis the standard IPP regimen had advantage for transfusion requirements, but no advantage with respect to inhospital rates of re-bleeding, need for surgery, length of hospitalstay, or death.http://www.ljkzedo.com.ba/medglasnik/vol81/MGvol81.2011_29.pdfpeptic ulcer bleedingproton pomp inhibitorendoscopic hemostasis |
| spellingShingle | Amila Mehmedović-Redžepović Rusmir Mesihović Besim Prnjavorac Aida Kulo Kalajdžija Merlina Hematologic and laboratory parameters in patientis with peptic ulcer bleeding treated by two modalities of endoscopic haemostasis and proton pompe inhibitors Medicinski Glasnik peptic ulcer bleeding proton pomp inhibitor endoscopic hemostasis |
| title | Hematologic and laboratory parameters in patientis with peptic ulcer bleeding treated by two modalities of endoscopic haemostasis and proton pompe inhibitors |
| title_full | Hematologic and laboratory parameters in patientis with peptic ulcer bleeding treated by two modalities of endoscopic haemostasis and proton pompe inhibitors |
| title_fullStr | Hematologic and laboratory parameters in patientis with peptic ulcer bleeding treated by two modalities of endoscopic haemostasis and proton pompe inhibitors |
| title_full_unstemmed | Hematologic and laboratory parameters in patientis with peptic ulcer bleeding treated by two modalities of endoscopic haemostasis and proton pompe inhibitors |
| title_short | Hematologic and laboratory parameters in patientis with peptic ulcer bleeding treated by two modalities of endoscopic haemostasis and proton pompe inhibitors |
| title_sort | hematologic and laboratory parameters in patientis with peptic ulcer bleeding treated by two modalities of endoscopic haemostasis and proton pompe inhibitors |
| topic | peptic ulcer bleeding proton pomp inhibitor endoscopic hemostasis |
| url | http://www.ljkzedo.com.ba/medglasnik/vol81/MGvol81.2011_29.pdf |
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