Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods
Enantioselective chromatography is one of the most used techniques for the separation and purification of enantiomers. The most important issue for a specific successful enantioseparation is the selection of the suitable chiral stationary phase (CSP). Different synthetic approaches have been applied...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/18/5477 |
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| author | Carla Fernandes Joana Teixeira Madalena M. M. Pinto Maria Elizabeth Tiritan |
| author_facet | Carla Fernandes Joana Teixeira Madalena M. M. Pinto Maria Elizabeth Tiritan |
| author_sort | Carla Fernandes |
| collection | DOAJ |
| description | Enantioselective chromatography is one of the most used techniques for the separation and purification of enantiomers. The most important issue for a specific successful enantioseparation is the selection of the suitable chiral stationary phase (CSP). Different synthetic approaches have been applied for the preparation of CSPs, which embrace coating and immobilization methods. In addition to the classical and broadly applied coating and immobilization procedures, innovating strategies have been introduced recently. In this review, an overview of different methods for the preparation of coated and immobilized CSPs is described. Updated examples of CSPs associated with the various strategies are presented. Considering that after the preparation of a CSP its characterization is fundamental, the methods used for the characterization of all the described CSPs are emphasized. |
| first_indexed | 2024-03-10T07:24:32Z |
| format | Article |
| id | doaj.art-cb0b6ff2dc5c4b04896315953220a258 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T07:24:32Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cb0b6ff2dc5c4b04896315953220a2582023-11-22T14:23:40ZengMDPI AGMolecules1420-30492021-09-012618547710.3390/molecules26185477Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization MethodsCarla Fernandes0Joana Teixeira1Madalena M. M. Pinto2Maria Elizabeth Tiritan3Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia da Universidade do Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, PortugalLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia da Universidade do Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, PortugalLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia da Universidade do Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, PortugalLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia da Universidade do Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, PortugalEnantioselective chromatography is one of the most used techniques for the separation and purification of enantiomers. The most important issue for a specific successful enantioseparation is the selection of the suitable chiral stationary phase (CSP). Different synthetic approaches have been applied for the preparation of CSPs, which embrace coating and immobilization methods. In addition to the classical and broadly applied coating and immobilization procedures, innovating strategies have been introduced recently. In this review, an overview of different methods for the preparation of coated and immobilized CSPs is described. Updated examples of CSPs associated with the various strategies are presented. Considering that after the preparation of a CSP its characterization is fundamental, the methods used for the characterization of all the described CSPs are emphasized.https://www.mdpi.com/1420-3049/26/18/5477chiral selectorclick chemistrycoupling agentdynamic coatingintermolecular polycondensationisocyanate derivatives |
| spellingShingle | Carla Fernandes Joana Teixeira Madalena M. M. Pinto Maria Elizabeth Tiritan Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods Molecules chiral selector click chemistry coupling agent dynamic coating intermolecular polycondensation isocyanate derivatives |
| title | Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods |
| title_full | Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods |
| title_fullStr | Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods |
| title_full_unstemmed | Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods |
| title_short | Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods |
| title_sort | strategies for preparation of chiral stationary phases progress on coating and immobilization methods |
| topic | chiral selector click chemistry coupling agent dynamic coating intermolecular polycondensation isocyanate derivatives |
| url | https://www.mdpi.com/1420-3049/26/18/5477 |
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