Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals
Rajan Rajabalaya, Muhammad Nuh Musa, Nurolaini Kifli, Sheba R David PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Brunei Darussalam Abstract: Liquid crystal (LC) dosage forms, particularly those using lipid-based lyotropic LCs (LLCs), have generated considerable interest as po...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-02-01
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| Series: | Drug Design, Development and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/oral-and-transdermal-drug-delivery-systems-role-of-lipid-based-lyotrop-peer-reviewed-article-DDDT |
| _version_ | 1811225010578128896 |
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| author | Rajabalaya R Musa MN Kifli N David SR |
| author_facet | Rajabalaya R Musa MN Kifli N David SR |
| author_sort | Rajabalaya R |
| collection | DOAJ |
| description | Rajan Rajabalaya, Muhammad Nuh Musa, Nurolaini Kifli, Sheba R David PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Brunei Darussalam Abstract: Liquid crystal (LC) dosage forms, particularly those using lipid-based lyotropic LCs (LLCs), have generated considerable interest as potential drug delivery systems. LCs have the physical properties of liquids but retain some of the structural characteristics of crystalline solids. They are compatible with hydrophobic and hydrophilic compounds of many different classes and can protect even biologicals and nucleic acids from degradation. This review, focused on research conducted over the past 5 years, discusses the structural evaluation of LCs and their effects in drug formulations. The structural classification of LLCs into lamellar, hexagonal and micellar cubic phases is described. The structures of these phases are influenced by the addition of surfactants, which include a variety of nontoxic, biodegradable lipids; these also enhance drug solubility. LLC structure influences drug localization, particle size and viscosity, which, in turn, determine drug delivery properties. Through several specific examples, we describe the applications of LLCs in oral and topical drug formulations, the latter including transdermal and ocular delivery. In oral LLC formulations, micelle compositions and the resulting LLC structures can determine drug solubilization and stability as well as intestinal transport and absorption. Similarly, in topical LLC formulations, composition can influence whether the drug is retained in the skin or delivered transdermally. Owing to their enhancement of drug stability and promotion of controlled drug delivery, LLCs are becoming increasingly popular in pharmaceutical formulations. Keywords: liquid crystal, drug delivery, controlled release, lyotropic, surfactants, drug localization |
| first_indexed | 2024-04-12T08:58:39Z |
| format | Article |
| id | doaj.art-cb0c67e99b7c4ec9ad23d63aa94046e8 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-04-12T08:58:39Z |
| publishDate | 2017-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-cb0c67e99b7c4ec9ad23d63aa94046e82022-12-22T03:39:18ZengDove Medical PressDrug Design, Development and Therapy1177-88812017-02-01Volume1139340631286Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystalsRajabalaya RMusa MNKifli NDavid SRRajan Rajabalaya, Muhammad Nuh Musa, Nurolaini Kifli, Sheba R David PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Brunei Darussalam Abstract: Liquid crystal (LC) dosage forms, particularly those using lipid-based lyotropic LCs (LLCs), have generated considerable interest as potential drug delivery systems. LCs have the physical properties of liquids but retain some of the structural characteristics of crystalline solids. They are compatible with hydrophobic and hydrophilic compounds of many different classes and can protect even biologicals and nucleic acids from degradation. This review, focused on research conducted over the past 5 years, discusses the structural evaluation of LCs and their effects in drug formulations. The structural classification of LLCs into lamellar, hexagonal and micellar cubic phases is described. The structures of these phases are influenced by the addition of surfactants, which include a variety of nontoxic, biodegradable lipids; these also enhance drug solubility. LLC structure influences drug localization, particle size and viscosity, which, in turn, determine drug delivery properties. Through several specific examples, we describe the applications of LLCs in oral and topical drug formulations, the latter including transdermal and ocular delivery. In oral LLC formulations, micelle compositions and the resulting LLC structures can determine drug solubilization and stability as well as intestinal transport and absorption. Similarly, in topical LLC formulations, composition can influence whether the drug is retained in the skin or delivered transdermally. Owing to their enhancement of drug stability and promotion of controlled drug delivery, LLCs are becoming increasingly popular in pharmaceutical formulations. Keywords: liquid crystal, drug delivery, controlled release, lyotropic, surfactants, drug localizationhttps://www.dovepress.com/oral-and-transdermal-drug-delivery-systems-role-of-lipid-based-lyotrop-peer-reviewed-article-DDDTliquid crystaldrug deliverycontrolled-releaselyotropicsurfactantsdrug localization |
| spellingShingle | Rajabalaya R Musa MN Kifli N David SR Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals Drug Design, Development and Therapy liquid crystal drug delivery controlled-release lyotropic surfactants drug localization |
| title | Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals |
| title_full | Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals |
| title_fullStr | Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals |
| title_full_unstemmed | Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals |
| title_short | Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals |
| title_sort | oral and transdermal drug delivery systems role of lipid based lyotropic liquid crystals |
| topic | liquid crystal drug delivery controlled-release lyotropic surfactants drug localization |
| url | https://www.dovepress.com/oral-and-transdermal-drug-delivery-systems-role-of-lipid-based-lyotrop-peer-reviewed-article-DDDT |
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