NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study
Background NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism reportedly influences the effects of cigarette smoking on respiratory function, risk of dyslipidemia, serum non-high-density lipoprotein cholesterol levels, hematological parameters and intraocular pressure...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2014-07-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/tid/NADH-dehydrogenase-subunit-2-237-Leu-Met-polymorphism-modifies-effects-of-cigarette-smoking-on-risk-of-elevated-levels-of-serum-liver-enzyme-in-male-Japanese-health-check-up-examinees-a-cross-sectional-study,67094,0,2.html |
| _version_ | 1828912886843441152 |
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| author | Akatsuki Kokaze Masao Yoshida Mamoru Ishikawa Naomi Matsunaga Kanae Karita Tadahiro Ohtsu Hirotaka Ochiai Takako Shirasawa Hinako Nanri Yuta Baba Hiromi Hoshino Yutaka Takashima |
| author_facet | Akatsuki Kokaze Masao Yoshida Mamoru Ishikawa Naomi Matsunaga Kanae Karita Tadahiro Ohtsu Hirotaka Ochiai Takako Shirasawa Hinako Nanri Yuta Baba Hiromi Hoshino Yutaka Takashima |
| author_sort | Akatsuki Kokaze |
| collection | DOAJ |
| description | Background
NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism reportedly influences the effects of cigarette smoking on respiratory function, risk of dyslipidemia, serum non-high-density lipoprotein cholesterol levels, hematological parameters and intraocular pressure. The objective of this study was to investigate whether ND2-237 Leu/Met polymorphism modifies the effects of cigarette smoking on serum liver enzyme levels in male Japanese health check-up examinees.
Methods
A total of 421 male subjects (mean age ± SD, 54.1 ± 7.7 years) were selected from among individuals visiting the hospital for regular medical check-ups. After ND2-237 Leu/Met genotyping, a cross-sectional study assessing the combined effects of ND2-237 Leu/Met polymorphism and cigarette smoking on serum aspartate aminotransferase levels, serum alanine aminotransferase (ALT) levels and serum gamma-glutamyltransferase (GGT) levels was then conducted.
Results
No statistically significant differences in serum liver enzyme levels among the three smoking status groups (never- or ex-smokers, 1–20 cigarettes smoked per day and >20 cigarettes smoked per day) by ND2-237 Leu/Met genotype were observed. However, for men with ND2-237Met, cigarette smoking significantly increased the risk of elevated levels of serum ALT (>30 U/L) or serum GGT (≥60 U/L or >51 U/L) (P for trend = 0.031, P for trend = 0.007 and P for trend = 0.004, respectively). After adjustment for age, body mass index, alcohol consumption, coffee consumption, antihypertensive treatment and antidiabetic treatment, a significant association between cigarette smoking and risk of elevated levels of serum ALT (>30 U/L) or serum GGT (≥60 U/L or >51 U/L) was also observed (P for trend = 0.032, P for trend = 0.019 and P for trend = 0.009, respectively). Surprisingly, for men with ND2-237Leu, cigarette smoking significantly decreased the risk of elevated levels of serum ALT (>30 U/L or ≥25 U/L) (P for trend = 0.026 and P for trend = 0.003, respectively).
Conclusions
Cigarette smoking appears to increase the risk of elevated levels of serum ALT or serum GGT in ND2-237Met genotypic men, but to decrease the risk of elevated levels of serum ALT in ND2-237Leu genotypic men. |
| first_indexed | 2024-12-13T19:27:25Z |
| format | Article |
| id | doaj.art-cb0f8a219f6846e793c7d93a689c232b |
| institution | Directory Open Access Journal |
| issn | 1617-9625 |
| language | English |
| last_indexed | 2024-12-13T19:27:25Z |
| publishDate | 2014-07-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj.art-cb0f8a219f6846e793c7d93a689c232b2022-12-21T23:34:00ZengEuropean PublishingTobacco Induced Diseases1617-96252014-07-0112July10.1186/1617-9625-12-1167094NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional studyAkatsuki Kokaze0Masao Yoshida1Mamoru Ishikawa2Naomi Matsunaga3Kanae Karita4Tadahiro Ohtsu5Hirotaka Ochiai6Takako Shirasawa7Hinako Nanri8Yuta Baba9Hiromi Hoshino10Yutaka Takashima11Department of Public Health, Showa University School of Medicine, Shinagawa-ku, JapanDepartment of Public Health, Kyorin University School of Medicine, Mitaka-shi, JapanDepartment of Public Health, Kyorin University School of Medicine, Mitaka-shi, JapanDepartment of Public Health, Kyorin University School of Medicine, Mitaka-shi, JapanDepartment of Public Health, Kyorin University School of Medicine, Mitaka-shi, JapanDepartment of Public Health, Showa University School of Medicine, Shinagawa-ku, JapanDepartment of Public Health, Showa University School of Medicine, Shinagawa-ku, JapanDepartment of Public Health, Showa University School of Medicine, Shinagawa-ku, JapanDepartment of Public Health, Showa University School of Medicine, Shinagawa-ku, JapanDepartment of Public Health, Showa University School of Medicine, Shinagawa-ku, JapanDepartment of Public Health, Showa University School of Medicine, Shinagawa-ku, JapanDepartment of Public Health, Kyorin University School of Medicine, Mitaka-shi, JapanBackground NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism reportedly influences the effects of cigarette smoking on respiratory function, risk of dyslipidemia, serum non-high-density lipoprotein cholesterol levels, hematological parameters and intraocular pressure. The objective of this study was to investigate whether ND2-237 Leu/Met polymorphism modifies the effects of cigarette smoking on serum liver enzyme levels in male Japanese health check-up examinees. Methods A total of 421 male subjects (mean age ± SD, 54.1 ± 7.7 years) were selected from among individuals visiting the hospital for regular medical check-ups. After ND2-237 Leu/Met genotyping, a cross-sectional study assessing the combined effects of ND2-237 Leu/Met polymorphism and cigarette smoking on serum aspartate aminotransferase levels, serum alanine aminotransferase (ALT) levels and serum gamma-glutamyltransferase (GGT) levels was then conducted. Results No statistically significant differences in serum liver enzyme levels among the three smoking status groups (never- or ex-smokers, 1–20 cigarettes smoked per day and >20 cigarettes smoked per day) by ND2-237 Leu/Met genotype were observed. However, for men with ND2-237Met, cigarette smoking significantly increased the risk of elevated levels of serum ALT (>30 U/L) or serum GGT (≥60 U/L or >51 U/L) (P for trend = 0.031, P for trend = 0.007 and P for trend = 0.004, respectively). After adjustment for age, body mass index, alcohol consumption, coffee consumption, antihypertensive treatment and antidiabetic treatment, a significant association between cigarette smoking and risk of elevated levels of serum ALT (>30 U/L) or serum GGT (≥60 U/L or >51 U/L) was also observed (P for trend = 0.032, P for trend = 0.019 and P for trend = 0.009, respectively). Surprisingly, for men with ND2-237Leu, cigarette smoking significantly decreased the risk of elevated levels of serum ALT (>30 U/L or ≥25 U/L) (P for trend = 0.026 and P for trend = 0.003, respectively). Conclusions Cigarette smoking appears to increase the risk of elevated levels of serum ALT or serum GGT in ND2-237Met genotypic men, but to decrease the risk of elevated levels of serum ALT in ND2-237Leu genotypic men.http://www.journalssystem.com/tid/NADH-dehydrogenase-subunit-2-237-Leu-Met-polymorphism-modifies-effects-of-cigarette-smoking-on-risk-of-elevated-levels-of-serum-liver-enzyme-in-male-Japanese-health-check-up-examinees-a-cross-sectional-study,67094,0,2.htmlalanine aminotransferasecigarette smokinggamma-glutamyltransferasemitochondrial DNA polymorphismNADH dehydrogenasereactive oxygen species |
| spellingShingle | Akatsuki Kokaze Masao Yoshida Mamoru Ishikawa Naomi Matsunaga Kanae Karita Tadahiro Ohtsu Hirotaka Ochiai Takako Shirasawa Hinako Nanri Yuta Baba Hiromi Hoshino Yutaka Takashima NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study Tobacco Induced Diseases alanine aminotransferase cigarette smoking gamma-glutamyltransferase mitochondrial DNA polymorphism NADH dehydrogenase reactive oxygen species |
| title | NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study |
| title_full | NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study |
| title_fullStr | NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study |
| title_full_unstemmed | NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study |
| title_short | NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study |
| title_sort | nadh dehydrogenase subunit 2 237 leu met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male japanese health check up examinees a cross sectional study |
| topic | alanine aminotransferase cigarette smoking gamma-glutamyltransferase mitochondrial DNA polymorphism NADH dehydrogenase reactive oxygen species |
| url | http://www.journalssystem.com/tid/NADH-dehydrogenase-subunit-2-237-Leu-Met-polymorphism-modifies-effects-of-cigarette-smoking-on-risk-of-elevated-levels-of-serum-liver-enzyme-in-male-Japanese-health-check-up-examinees-a-cross-sectional-study,67094,0,2.html |
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