Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity
Dayalan Sampath,1 Monica Sathyanesan,1,2 Samuel S Newton1,2 1Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, 2Sioux Falls VA Healthcare System, Sioux Falls, SD, USA Abstract: Cognitive dysfunction is prevalent in psychiatric disorders. Def...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-06-01
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| Series: | Neuropsychiatric Disease and Treatment |
| Subjects: | |
| Online Access: | https://www.dovepress.com/cognitive-dysfunction-in-major-depression-and-alzheimer39s-disease-is--peer-reviewed-article-NDT |
| _version_ | 1818980578120171520 |
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| author | Sampath D Sathyanesan M Newton SS |
| author_facet | Sampath D Sathyanesan M Newton SS |
| author_sort | Sampath D |
| collection | DOAJ |
| description | Dayalan Sampath,1 Monica Sathyanesan,1,2 Samuel S Newton1,2 1Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, 2Sioux Falls VA Healthcare System, Sioux Falls, SD, USA Abstract: Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology. The goal of this review is to shed light on the contributions of this circuit to cognitive dysfunction in neuropsychiatric disorders, focusing on Alzheimer’s disease and depression. Keywords: hippocampus, prefrontal cortex, cognition, depression, Alzheimer’s disease |
| first_indexed | 2024-12-20T17:17:39Z |
| format | Article |
| id | doaj.art-cb0fa1ae46a7485c8503e0fec76ec8b6 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-20T17:17:39Z |
| publishDate | 2017-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-cb0fa1ae46a7485c8503e0fec76ec8b62022-12-21T19:31:56ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212017-06-01Volume 131509151933244Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivitySampath DSathyanesan MNewton SSDayalan Sampath,1 Monica Sathyanesan,1,2 Samuel S Newton1,2 1Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, 2Sioux Falls VA Healthcare System, Sioux Falls, SD, USA Abstract: Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology. The goal of this review is to shed light on the contributions of this circuit to cognitive dysfunction in neuropsychiatric disorders, focusing on Alzheimer’s disease and depression. Keywords: hippocampus, prefrontal cortex, cognition, depression, Alzheimer’s diseasehttps://www.dovepress.com/cognitive-dysfunction-in-major-depression-and-alzheimer39s-disease-is--peer-reviewed-article-NDTHippocampusPrefrontal cortexCognition DepressionAlzheimers disease |
| spellingShingle | Sampath D Sathyanesan M Newton SS Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity Neuropsychiatric Disease and Treatment Hippocampus Prefrontal cortex Cognition Depression Alzheimers disease |
| title | Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| title_full | Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| title_fullStr | Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| title_full_unstemmed | Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| title_short | Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| title_sort | cognitive dysfunction in major depression and alzheimer 39 s disease is associated with hippocampus ndash prefrontal cortex dysconnectivity |
| topic | Hippocampus Prefrontal cortex Cognition Depression Alzheimers disease |
| url | https://www.dovepress.com/cognitive-dysfunction-in-major-depression-and-alzheimer39s-disease-is--peer-reviewed-article-NDT |
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