二甲双胍和生长分化因子15 (GDF15)在2型糖尿病中的作用:一个隐藏的宝藏
Abstract Type 2 diabetes mellitus (T2DM) is a chronic endocrine disorder due to the reduction of insulin sensitivity and relative deficiency of insulin secretion. Growth differentiation factor 15 (GDF15) belongs to the transforming growth factor beta (TGF‐β) superfamily and was initially identified...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-12-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13334 |
| _version_ | 1797978042022232064 |
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| author | Hayder M. Al‐kuraishy Ali I. Al‐Gareeb Athanasios Alexiou Marios Papadakis Eman Hassan Nadwa Sarah M. Albogami Mohammed Alorabi Hebatallah M. Saad Gaber El‐Saber Batiha |
| author_facet | Hayder M. Al‐kuraishy Ali I. Al‐Gareeb Athanasios Alexiou Marios Papadakis Eman Hassan Nadwa Sarah M. Albogami Mohammed Alorabi Hebatallah M. Saad Gaber El‐Saber Batiha |
| author_sort | Hayder M. Al‐kuraishy |
| collection | DOAJ |
| description | Abstract Type 2 diabetes mellitus (T2DM) is a chronic endocrine disorder due to the reduction of insulin sensitivity and relative deficiency of insulin secretion. Growth differentiation factor 15 (GDF15) belongs to the transforming growth factor beta (TGF‐β) superfamily and was initially identified as macrophage inhibitory cytokine‐1 (MIC‐1). GDF15 is considered a cytokine with an anti‐inflammatory effect and increases insulin sensitivity, reduces body weight, and improves clinical outcomes in diabetic patients. GDF15 acts through stimulation of glial‐derived neurotrophic factor (GDNF) family receptor α‐like (GFRAL), which is highly expressed in the brain stem to induce taste aversion. Metformin belongs to the group of biguanides that are derived from the plant Galega officinalis. It is interesting to note that metformin is an insulin‐sensitizing agent used as a first‐line therapy for T2DM that has been shown to increase the circulating level of GDF15. Thus, the present review aims to determine the critical association of the GDF15 biomarker in T2DM and how metformin agents affect it. This review illustrates that metformin activates GDF15 expression, which reduces appetite and leads to weight loss in both diabetic and nondiabetic patients. However, the present review cannot give a conclusion in this regard. Therefore, experimental, preclinical, and clinical studies are warranted to confirm the potential role of GDF15 in T2DM patients. |
| first_indexed | 2024-04-11T05:16:41Z |
| format | Article |
| id | doaj.art-cb0faae2b681447ca78abf9c856e75ef |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-04-11T05:16:41Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-cb0faae2b681447ca78abf9c856e75ef2022-12-24T08:16:32ZengWileyJournal of Diabetes1753-03931753-04072022-12-01141280681410.1111/1753-0407.13334二甲双胍和生长分化因子15 (GDF15)在2型糖尿病中的作用:一个隐藏的宝藏Hayder M. Al‐kuraishy0Ali I. Al‐Gareeb1Athanasios Alexiou2Marios Papadakis3Eman Hassan Nadwa4Sarah M. Albogami5Mohammed Alorabi6Hebatallah M. Saad7Gaber El‐Saber Batiha8Department of Clinical Pharmacology and Medicine, College of Medicine AL‐Mustansiriyah University Baghdad IraqDepartment of Clinical Pharmacology and Medicine, College of Medicine AL‐Mustansiriyah University Baghdad IraqDepartment of Science and Engineering Novel Global Community Educational Foundation Hebersham AustraliaDepartment of Surgery II, University Hospital Witten‐Herdecke, Heusnerstrasse 40 Wuppertal GermanyDepartment of Pharmacology and Therapeutics College of Medicine, Jouf University Sakakah Saudi ArabiaDepartment of Biotechnology College of Science, Taif University Taif Saudi ArabiaDepartment of Biotechnology College of Science, Taif University Taif Saudi ArabiaDepartment of Pathology, Faculty of Veterinary Medicine Matrouh University Marsa Matruh EgyptDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine Damanhour University Damanhour EgyptAbstract Type 2 diabetes mellitus (T2DM) is a chronic endocrine disorder due to the reduction of insulin sensitivity and relative deficiency of insulin secretion. Growth differentiation factor 15 (GDF15) belongs to the transforming growth factor beta (TGF‐β) superfamily and was initially identified as macrophage inhibitory cytokine‐1 (MIC‐1). GDF15 is considered a cytokine with an anti‐inflammatory effect and increases insulin sensitivity, reduces body weight, and improves clinical outcomes in diabetic patients. GDF15 acts through stimulation of glial‐derived neurotrophic factor (GDNF) family receptor α‐like (GFRAL), which is highly expressed in the brain stem to induce taste aversion. Metformin belongs to the group of biguanides that are derived from the plant Galega officinalis. It is interesting to note that metformin is an insulin‐sensitizing agent used as a first‐line therapy for T2DM that has been shown to increase the circulating level of GDF15. Thus, the present review aims to determine the critical association of the GDF15 biomarker in T2DM and how metformin agents affect it. This review illustrates that metformin activates GDF15 expression, which reduces appetite and leads to weight loss in both diabetic and nondiabetic patients. However, the present review cannot give a conclusion in this regard. Therefore, experimental, preclinical, and clinical studies are warranted to confirm the potential role of GDF15 in T2DM patients.https://doi.org/10.1111/1753-0407.133342型糖尿病二甲双胍生长分化因子15 |
| spellingShingle | Hayder M. Al‐kuraishy Ali I. Al‐Gareeb Athanasios Alexiou Marios Papadakis Eman Hassan Nadwa Sarah M. Albogami Mohammed Alorabi Hebatallah M. Saad Gaber El‐Saber Batiha 二甲双胍和生长分化因子15 (GDF15)在2型糖尿病中的作用:一个隐藏的宝藏 Journal of Diabetes 2型糖尿病 二甲双胍 生长分化因子15 |
| title | 二甲双胍和生长分化因子15 (GDF15)在2型糖尿病中的作用:一个隐藏的宝藏 |
| title_full | 二甲双胍和生长分化因子15 (GDF15)在2型糖尿病中的作用:一个隐藏的宝藏 |
| title_fullStr | 二甲双胍和生长分化因子15 (GDF15)在2型糖尿病中的作用:一个隐藏的宝藏 |
| title_full_unstemmed | 二甲双胍和生长分化因子15 (GDF15)在2型糖尿病中的作用:一个隐藏的宝藏 |
| title_short | 二甲双胍和生长分化因子15 (GDF15)在2型糖尿病中的作用:一个隐藏的宝藏 |
| title_sort | 二甲双胍和生长分化因子15 gdf15 在2型糖尿病中的作用 一个隐藏的宝藏 |
| topic | 2型糖尿病 二甲双胍 生长分化因子15 |
| url | https://doi.org/10.1111/1753-0407.13334 |
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