Diagnostic significance of markers of inflammation in the cervical canal in pregnant women with bacterial vaginosis
The aim of the study was to determine the proinflammatory and anti-inflammatory cytokines in the cervical canal as indicators of the state of local immunity in pregnant women with bacterial vaginosis (BV). Material and methods. The study included 45 pregnant women, who applied early in gestation. Th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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IP Berlin A.V.
2018-02-01
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| Series: | Гинекология |
| Subjects: | |
| Online Access: | https://gynecology.orscience.ru/2079-5831/article/viewFile/30053/pdf |
| _version_ | 1818387343994781696 |
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| author | T E Karapetian N A Lomova M I Kesova |
| author_facet | T E Karapetian N A Lomova M I Kesova |
| author_sort | T E Karapetian |
| collection | DOAJ |
| description | The aim of the study was to determine the proinflammatory and anti-inflammatory cytokines in the cervical canal as indicators of the state of local immunity in pregnant women with bacterial vaginosis (BV). Material and methods. The study included 45 pregnant women, who applied early in gestation. The main group consisted of 32 pregnant women, who had verified the diagnosis of BV, the comparison group - 13 pregnant women with normal vaginal microbiocenosis. In the mucus from the cervical canal, the content of pro-inflammatory cytokines (tumor necrosis factor a, interferon-g, interleukins - IL-1a, IL-2, IL-6, IL-8) and anti-inflammatory cytokines (IL-4, IL-10) was determined. Results. Local immunity before treatment of pregnant women with BV was characterized by a significant increase in the level of pro- and anti-inflammatory cytokines in relation to their production in pregnant women with normal vaginal microcenosis. After treatment with BV, cytokine levels were approaching those of healthy pregnant women, but the levels of tumor necrosis factor a and IL-8 changed little, which is probably due to the low production of these cytokines, since the leukocyte reaction in the epithelial vaginal locus is not expressed in vaginosis. The conclusion. Qualitative and quantitative changes in cytokine levels reflect the degree of activation of immunocompetent cells in any pathological process. The results obtained in this study reflect a certain autonomy of immune responses in the lower sections of the female genital tract. |
| first_indexed | 2024-12-14T04:08:27Z |
| format | Article |
| id | doaj.art-cb1022df287f42f5aa73ecdfca7d38b9 |
| institution | Directory Open Access Journal |
| issn | 2079-5696 2079-5831 |
| language | Russian |
| last_indexed | 2024-12-14T04:08:27Z |
| publishDate | 2018-02-01 |
| publisher | IP Berlin A.V. |
| record_format | Article |
| series | Гинекология |
| spelling | doaj.art-cb1022df287f42f5aa73ecdfca7d38b92022-12-21T23:17:45ZrusIP Berlin A.V.Гинекология2079-56962079-58312018-02-01201717427081Diagnostic significance of markers of inflammation in the cervical canal in pregnant women with bacterial vaginosisT E Karapetian0N A Lomova1M I Kesova2V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian FederationV.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian FederationV.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian FederationThe aim of the study was to determine the proinflammatory and anti-inflammatory cytokines in the cervical canal as indicators of the state of local immunity in pregnant women with bacterial vaginosis (BV). Material and methods. The study included 45 pregnant women, who applied early in gestation. The main group consisted of 32 pregnant women, who had verified the diagnosis of BV, the comparison group - 13 pregnant women with normal vaginal microbiocenosis. In the mucus from the cervical canal, the content of pro-inflammatory cytokines (tumor necrosis factor a, interferon-g, interleukins - IL-1a, IL-2, IL-6, IL-8) and anti-inflammatory cytokines (IL-4, IL-10) was determined. Results. Local immunity before treatment of pregnant women with BV was characterized by a significant increase in the level of pro- and anti-inflammatory cytokines in relation to their production in pregnant women with normal vaginal microcenosis. After treatment with BV, cytokine levels were approaching those of healthy pregnant women, but the levels of tumor necrosis factor a and IL-8 changed little, which is probably due to the low production of these cytokines, since the leukocyte reaction in the epithelial vaginal locus is not expressed in vaginosis. The conclusion. Qualitative and quantitative changes in cytokine levels reflect the degree of activation of immunocompetent cells in any pathological process. The results obtained in this study reflect a certain autonomy of immune responses in the lower sections of the female genital tract.https://gynecology.orscience.ru/2079-5831/article/viewFile/30053/pdfbacterial vaginosispregnancycytokines |
| spellingShingle | T E Karapetian N A Lomova M I Kesova Diagnostic significance of markers of inflammation in the cervical canal in pregnant women with bacterial vaginosis Гинекология bacterial vaginosis pregnancy cytokines |
| title | Diagnostic significance of markers of inflammation in the cervical canal in pregnant women with bacterial vaginosis |
| title_full | Diagnostic significance of markers of inflammation in the cervical canal in pregnant women with bacterial vaginosis |
| title_fullStr | Diagnostic significance of markers of inflammation in the cervical canal in pregnant women with bacterial vaginosis |
| title_full_unstemmed | Diagnostic significance of markers of inflammation in the cervical canal in pregnant women with bacterial vaginosis |
| title_short | Diagnostic significance of markers of inflammation in the cervical canal in pregnant women with bacterial vaginosis |
| title_sort | diagnostic significance of markers of inflammation in the cervical canal in pregnant women with bacterial vaginosis |
| topic | bacterial vaginosis pregnancy cytokines |
| url | https://gynecology.orscience.ru/2079-5831/article/viewFile/30053/pdf |
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