A Pattern of Care Report on the Management of Patients with Squamous Cell Carcinoma of the Anus—A Study by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Tumors Study Group
<i>Background and objectives:</i> The diagnosis and therapy of squamous cell carcinoma of the anus may vary significantly in daily clinical practice, even if international guidelines are available. <i>Materials and Methods:</i> We conducted a pattern of care survey to assess...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/57/12/1342 |
| _version_ | 1797502609922195456 |
|---|---|
| author | Pierfrancesco Franco Giuditta Chiloiro Giampaolo Montesi Sabrina Montrone Alessandra Arcelli Tiziana Comito Francesca Arcadipane Luciana Caravatta Gabriella Macchia Marco Lupattelli Marina Rita Niespolo Fernando Munoz Elisa Palazzari Marco Krengli Francesca Valvo Maria Antonietta Gambacorta Domenico Genovesi Giovanna Mantello |
| author_facet | Pierfrancesco Franco Giuditta Chiloiro Giampaolo Montesi Sabrina Montrone Alessandra Arcelli Tiziana Comito Francesca Arcadipane Luciana Caravatta Gabriella Macchia Marco Lupattelli Marina Rita Niespolo Fernando Munoz Elisa Palazzari Marco Krengli Francesca Valvo Maria Antonietta Gambacorta Domenico Genovesi Giovanna Mantello |
| author_sort | Pierfrancesco Franco |
| collection | DOAJ |
| description | <i>Background and objectives:</i> The diagnosis and therapy of squamous cell carcinoma of the anus may vary significantly in daily clinical practice, even if international guidelines are available. <i>Materials and Methods:</i> We conducted a pattern of care survey to assess the management of patients with anal cancer in Italy (38 questions). We analyzed 58 questionnaires. <i>Results:</i> Most of the respondents work in public and/or university hospitals (75.8%) in northern Italy (65.5%). The majority (88.0%) treat less than 20 patients/year. Common examinations for diagnosis and staging are anorectal endoscopy (84.5%), computed tomography scan (86.2%) and pelvic magnetic resonance imaging (MRI) (96.5%). The most frequently prescribed dose to primary tumor is 50–54 Gy (46.5–58.6%) for early stage disease and 54–59.4 Gy (62.1–32.8%) for locally advanced cases. Elective volumes are prescribed around 45 Gy (94.8%). Most participants use volumetric intensity modulated radiotherapy (89.7%) and a simultaneous integrated boost (84.5%). Concurrent radiotherapy, 5-fluorouracil and mitomycin is considered the standard of care (70.6%). Capecitabine is less frequently used (34.4%). Induction chemotherapy is an option for extensive localized disease (65.5%). Consolidation chemotherapy is rarely used (18.9%). A response evaluation is conducted at 26–30 weeks (63.9%) with a pelvic MRI (91.4%). Follow-up is generally run by the multidisciplinary tumor board (62.1%). <i>Conclusions:</i> Differences were observed for radiotherapy dose prescription, calling for a consensus to harmonize treatment strategies. |
| first_indexed | 2024-03-10T03:36:34Z |
| format | Article |
| id | doaj.art-cb11e5d462754e7f9bacc4dd3d9c2084 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T03:36:34Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-cb11e5d462754e7f9bacc4dd3d9c20842023-11-23T09:28:39ZengMDPI AGMedicina1010-660X1648-91442021-12-015712134210.3390/medicina57121342A Pattern of Care Report on the Management of Patients with Squamous Cell Carcinoma of the Anus—A Study by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Tumors Study GroupPierfrancesco Franco0Giuditta Chiloiro1Giampaolo Montesi2Sabrina Montrone3Alessandra Arcelli4Tiziana Comito5Francesca Arcadipane6Luciana Caravatta7Gabriella Macchia8Marco Lupattelli9Marina Rita Niespolo10Fernando Munoz11Elisa Palazzari12Marco Krengli13Francesca Valvo14Maria Antonietta Gambacorta15Domenico Genovesi16Giovanna Mantello17Department of Translational Medicine, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, ItalyFondazione Policlinico Universitario ‘Agostino Gemelli’ IRCCS, Via della Pineta Sacchetti, 00168 Rome, ItalyRadiation Oncology Department, ‘S.M. Della Misericordia’ Hospital, AULSS 5 Veneto, Viale Tre Martiri 140, 45100 Rovigo, ItalyRadiation Oncology Unit, Pisa University Hospital, Via Roma 67, 56123 Pisa, ItalyRadiation Oncology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 9, 40138 Bologna, ItalyRadiotherapy Department, Humanitas Clinical and Research Hospital IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, ItalyDepartment of Oncology, Radiation Oncology, AOU ‘Citta’ della Salute e della Scienza’, Via Cavour 31, 10123 Turin, ItalyRadiation Oncology Unit, ‘SS Annunziata Hospital’, ‘G. D’Annunzio’ University of Chieti-Pescara, Via dei Vestini, 66100 Chieti, ItalyRadiation Oncology Unit, Gemelli Molise Hospital–Universita’ Cattolica del Sacro Cuore, Largo Agostino Gemelli 1, 86100 Campobasso, ItalyRadiation Oncology Section, Perugia General Hospital, Piazzale Meneghini 1, 06156 Perugia, ItalyDepartment of Radiation Oncology, Azienda Ospedaliera S. Gerardo, Via Pergolesi 33, 20900 Monza, ItalyRadiation Oncology Department, ‘Umberto Parini’ Regional Hospital, AUSL Valle d’Aosta, Aosta, Viale Ginevra 3, 11100 Aosta, ItalyRadiation Oncology Department, Oncological Referral Center, Via Gallini 2, 33081 Aviano, ItalyDepartment of Translational Medicine, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, ItalyScientific Direction Unit, National Center for Oncological Hadrontherapy (CNAO), Strada Campeggi 53, 27100 Pavia, ItalyFondazione Policlinico Universitario ‘Agostino Gemelli’ IRCCS, Via della Pineta Sacchetti, 00168 Rome, ItalyRadiation Oncology Unit, ‘SS Annunziata Hospital’, ‘G. D’Annunzio’ University of Chieti-Pescara, Via dei Vestini, 66100 Chieti, ItalyDepartment of Oncology and Radiotherapy, Azienda Ospedaliero Universitaria Ospedali Riuniti, Via Conca 71, Torrette, 60002 Ancona, Italy<i>Background and objectives:</i> The diagnosis and therapy of squamous cell carcinoma of the anus may vary significantly in daily clinical practice, even if international guidelines are available. <i>Materials and Methods:</i> We conducted a pattern of care survey to assess the management of patients with anal cancer in Italy (38 questions). We analyzed 58 questionnaires. <i>Results:</i> Most of the respondents work in public and/or university hospitals (75.8%) in northern Italy (65.5%). The majority (88.0%) treat less than 20 patients/year. Common examinations for diagnosis and staging are anorectal endoscopy (84.5%), computed tomography scan (86.2%) and pelvic magnetic resonance imaging (MRI) (96.5%). The most frequently prescribed dose to primary tumor is 50–54 Gy (46.5–58.6%) for early stage disease and 54–59.4 Gy (62.1–32.8%) for locally advanced cases. Elective volumes are prescribed around 45 Gy (94.8%). Most participants use volumetric intensity modulated radiotherapy (89.7%) and a simultaneous integrated boost (84.5%). Concurrent radiotherapy, 5-fluorouracil and mitomycin is considered the standard of care (70.6%). Capecitabine is less frequently used (34.4%). Induction chemotherapy is an option for extensive localized disease (65.5%). Consolidation chemotherapy is rarely used (18.9%). A response evaluation is conducted at 26–30 weeks (63.9%) with a pelvic MRI (91.4%). Follow-up is generally run by the multidisciplinary tumor board (62.1%). <i>Conclusions:</i> Differences were observed for radiotherapy dose prescription, calling for a consensus to harmonize treatment strategies.https://www.mdpi.com/1648-9144/57/12/1342anal cancersquamous cell carcinomaanuschemoradiationradiotherapypattern of care |
| spellingShingle | Pierfrancesco Franco Giuditta Chiloiro Giampaolo Montesi Sabrina Montrone Alessandra Arcelli Tiziana Comito Francesca Arcadipane Luciana Caravatta Gabriella Macchia Marco Lupattelli Marina Rita Niespolo Fernando Munoz Elisa Palazzari Marco Krengli Francesca Valvo Maria Antonietta Gambacorta Domenico Genovesi Giovanna Mantello A Pattern of Care Report on the Management of Patients with Squamous Cell Carcinoma of the Anus—A Study by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Tumors Study Group Medicina anal cancer squamous cell carcinoma anus chemoradiation radiotherapy pattern of care |
| title | A Pattern of Care Report on the Management of Patients with Squamous Cell Carcinoma of the Anus—A Study by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Tumors Study Group |
| title_full | A Pattern of Care Report on the Management of Patients with Squamous Cell Carcinoma of the Anus—A Study by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Tumors Study Group |
| title_fullStr | A Pattern of Care Report on the Management of Patients with Squamous Cell Carcinoma of the Anus—A Study by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Tumors Study Group |
| title_full_unstemmed | A Pattern of Care Report on the Management of Patients with Squamous Cell Carcinoma of the Anus—A Study by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Tumors Study Group |
| title_short | A Pattern of Care Report on the Management of Patients with Squamous Cell Carcinoma of the Anus—A Study by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Tumors Study Group |
| title_sort | pattern of care report on the management of patients with squamous cell carcinoma of the anus a study by the italian association of radiotherapy and clinical oncology airo gastrointestinal tumors study group |
| topic | anal cancer squamous cell carcinoma anus chemoradiation radiotherapy pattern of care |
| url | https://www.mdpi.com/1648-9144/57/12/1342 |
| work_keys_str_mv | AT pierfrancescofranco apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT giudittachiloiro apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT giampaolomontesi apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT sabrinamontrone apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT alessandraarcelli apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT tizianacomito apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT francescaarcadipane apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT lucianacaravatta apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT gabriellamacchia apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT marcolupattelli apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT marinaritaniespolo apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT fernandomunoz apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT elisapalazzari apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT marcokrengli apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT francescavalvo apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT mariaantoniettagambacorta apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT domenicogenovesi apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT giovannamantello apatternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT pierfrancescofranco patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT giudittachiloiro patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT giampaolomontesi patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT sabrinamontrone patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT alessandraarcelli patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT tizianacomito patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT francescaarcadipane patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT lucianacaravatta patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT gabriellamacchia patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT marcolupattelli patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT marinaritaniespolo patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT fernandomunoz patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT elisapalazzari patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT marcokrengli patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT francescavalvo patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT mariaantoniettagambacorta patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT domenicogenovesi patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup AT giovannamantello patternofcarereportonthemanagementofpatientswithsquamouscellcarcinomaoftheanusastudybytheitalianassociationofradiotherapyandclinicaloncologyairogastrointestinaltumorsstudygroup |