Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1
Excitotoxicity due to excessive glutamate release causes oxidative stress and neuronal death, and is a feature of many brain diseases. Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its activation can be neuroprotective.
Bibliographic Details
| Main Authors: |
Julia Pose-Utrilla,
Lucía García-Guerra,
Ana Del Puerto,
Abraham Martín,
Jerónimo Jurado-Arjona,
Noelia S. De León-Reyes,
Andrea Gamir-Morralla,
Álvaro Sebastián-Serrano,
Mónica García-Gallo,
Leonor Kremer,
Jens Fielitz,
Christofer Ireson,
Mª José Pérez-Álvarez,
Isidro Ferrer,
Félix Hernández,
Jesús Ávila,
Marina Lasa,
Miguel R. Campanero,
Teresa Iglesias |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2017-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-02322-5
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