Formulation and Investigation Antioxidant of O/W Cream Containing Euphorbia hirta L. Herb Extract
The herb extract of Euphorbia hirta L. have been reported as sources of inexpensive antioxidant that can be used as potential cosmetic product. Therefore, the aims of this study were to formulate E. hirta L. extract loaded cream and to assess the antioxidant activity of loaded cream. First, E. hirta...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2020-01-01
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| Series: | E3S Web of Conferences |
| Subjects: | |
| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2020/11/e3sconf_icvaes2020_01001.pdf |
| _version_ | 1818445525096071168 |
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| author | Gani Fadli A. Isnaini Nadia Maryam Siti |
| author_facet | Gani Fadli A. Isnaini Nadia Maryam Siti |
| author_sort | Gani Fadli A. |
| collection | DOAJ |
| description | The herb extract of Euphorbia hirta L. have been reported as sources of inexpensive antioxidant that can be used as potential cosmetic product. Therefore, the aims of this study were to formulate E. hirta L. extract loaded cream and to assess the antioxidant activity of loaded cream. First, E. hirta L. was prepared with maceration process using water as solvent (1:5). Afterwards, the obtained extract was subjected to a lyophilisation process. The extract was tasted for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) for suitable concentration of the extract incorporated into the cream, which was 10%w/w. The cream was formulated as o/w emulsion and stearic acid was selected as an emulsifier. The extract loaded cream was tested pH, viscosity, and antioxidant. The freshly prepared extract loaded cream was dark green and no phase separation was observed after centrifugation at 3,000 rpm for 30 min. They had acidic pH (4.4-5.1), considered acceptable for skin application, especially in skin face. The DPPH measurement revealed that the formulation had potential antioxidant activity with %SCV more than 80% at 100 µg/mL. In conclusion, topical o/w cream containing extract was successfully prepared with substantial antioxidant activity and was displayed a potential use in cosmetic formulations, especially antiaging products. |
| first_indexed | 2024-12-14T19:33:13Z |
| format | Article |
| id | doaj.art-cb12a309680a4335a8405360128f8cbe |
| institution | Directory Open Access Journal |
| issn | 2267-1242 |
| language | English |
| last_indexed | 2024-12-14T19:33:13Z |
| publishDate | 2020-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj.art-cb12a309680a4335a8405360128f8cbe2022-12-21T22:50:01ZengEDP SciencesE3S Web of Conferences2267-12422020-01-011510100110.1051/e3sconf/202015101001e3sconf_icvaes2020_01001Formulation and Investigation Antioxidant of O/W Cream Containing Euphorbia hirta L. Herb ExtractGani Fadli A.0Isnaini Nadia1Maryam Siti2Faculty of Veterinary Medicine, Syiah Kuala UniversityFaculty of Pharmaceutical Sciences, Prince of Songkla UniversityFaculty of Teacher Training and Education, Syiah Kuala UniversityThe herb extract of Euphorbia hirta L. have been reported as sources of inexpensive antioxidant that can be used as potential cosmetic product. Therefore, the aims of this study were to formulate E. hirta L. extract loaded cream and to assess the antioxidant activity of loaded cream. First, E. hirta L. was prepared with maceration process using water as solvent (1:5). Afterwards, the obtained extract was subjected to a lyophilisation process. The extract was tasted for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) for suitable concentration of the extract incorporated into the cream, which was 10%w/w. The cream was formulated as o/w emulsion and stearic acid was selected as an emulsifier. The extract loaded cream was tested pH, viscosity, and antioxidant. The freshly prepared extract loaded cream was dark green and no phase separation was observed after centrifugation at 3,000 rpm for 30 min. They had acidic pH (4.4-5.1), considered acceptable for skin application, especially in skin face. The DPPH measurement revealed that the formulation had potential antioxidant activity with %SCV more than 80% at 100 µg/mL. In conclusion, topical o/w cream containing extract was successfully prepared with substantial antioxidant activity and was displayed a potential use in cosmetic formulations, especially antiaging products.https://www.e3s-conferences.org/articles/e3sconf/pdf/2020/11/e3sconf_icvaes2020_01001.pdfeuphorbia hirta extractcreamantioxidanttopical delivery |
| spellingShingle | Gani Fadli A. Isnaini Nadia Maryam Siti Formulation and Investigation Antioxidant of O/W Cream Containing Euphorbia hirta L. Herb Extract E3S Web of Conferences euphorbia hirta extract cream antioxidant topical delivery |
| title | Formulation and Investigation Antioxidant of O/W Cream Containing Euphorbia hirta L. Herb Extract |
| title_full | Formulation and Investigation Antioxidant of O/W Cream Containing Euphorbia hirta L. Herb Extract |
| title_fullStr | Formulation and Investigation Antioxidant of O/W Cream Containing Euphorbia hirta L. Herb Extract |
| title_full_unstemmed | Formulation and Investigation Antioxidant of O/W Cream Containing Euphorbia hirta L. Herb Extract |
| title_short | Formulation and Investigation Antioxidant of O/W Cream Containing Euphorbia hirta L. Herb Extract |
| title_sort | formulation and investigation antioxidant of o w cream containing euphorbia hirta l herb extract |
| topic | euphorbia hirta extract cream antioxidant topical delivery |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2020/11/e3sconf_icvaes2020_01001.pdf |
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