Cognitive Impairment in Children with Beta-Thalassaemia Major at a Tertiary Care Centre, Rajasthan, India: A Cross-sectional Study
Introduction: Thalassaemia is one of the most common genetic disorders. Iron overload due to repeated blood transfusions and chelating therapy leads to oxidative stress and possible irreversible brain tissue damage, causing cognitive impairment in these children. Aim: To study cognitive impairment...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2023-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/17448/58857_CE[Ra1]_F(KM)_PF1(JY_SHU_SS)_PFA(SS)_PB(JY_SS)_PN(SS).pdf |
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| author | Sandeep Avasarala Anubhav Choudhary Kuldeep Singh Bithu Renu Agrawal Gajanand Singh Tanwar |
| author_facet | Sandeep Avasarala Anubhav Choudhary Kuldeep Singh Bithu Renu Agrawal Gajanand Singh Tanwar |
| author_sort | Sandeep Avasarala |
| collection | DOAJ |
| description | Introduction: Thalassaemia is one of the most common genetic disorders. Iron overload due to repeated blood transfusions and chelating therapy leads to oxidative stress and possible irreversible brain tissue damage, causing cognitive impairment in these children.
Aim: To study cognitive impairment in children with beta thalassaemia major in a tertiary care centre in Bikaner, Rajasthan, India.
Materials and Methods: This was a hospital-based cross-sectional observational study conducted in the Department of Paediatrics, Sardar Patel Medical College, Bikaner, Rajasthan, India from September 2019 to August 2020. Sixty-five children with thalassaemia and 65 children without thalassaemia (as controls) were recruited and assessed using modified Mini-Mental State Examination (MMSE) for cognitive impairment.
Results: Majority of children belonged to age group 6-11 years (67.7% in cases and 68.8% in controls). The mean MMSE scores were significantly lower among children with thalassaemia (26.82±6.45) compared to the controls (29.08±5.71). There was a significantly higher prevalence of cognitive dysfunction in thalassaemia children (72.3%) as compared to controls (33.8%). Children who were compliant with chelation medications (n=30) were found to have a lesser prevalence of cognitive dysfunction (60%) than those who were not compliant (n=35) with medications (82.86%) (p-value=0.013). Among cases, the mean ferritin levels were higher in children with cognitive dysfunction (3399.00±1489.18) compared to those with normal cognitive function (2412.38±1117.26) (p-value=0.046). There was moderate positive correlation between thalassaemia child’s Body Mass Index (BMI) and modified MMSE score.
Conclusion: This study highlights the higher prevalence of cognitive impairment in children with thalassaemia (72.3%). The key contributing factors were- lack of compliance to chelation therapy, higher serum ferritin levels and low BMI. |
| first_indexed | 2024-04-10T00:38:53Z |
| format | Article |
| id | doaj.art-cb13914f7e644b4faadc7883d2ca1233 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T00:38:53Z |
| publishDate | 2023-02-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-cb13914f7e644b4faadc7883d2ca12332023-03-14T09:08:32ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-02-01172SC04SC0710.7860/JCDR/2023/58857.17448Cognitive Impairment in Children with Beta-Thalassaemia Major at a Tertiary Care Centre, Rajasthan, India: A Cross-sectional StudySandeep Avasarala0Anubhav Choudhary1Kuldeep Singh Bithu2Renu Agrawal3Gajanand Singh Tanwar4Medical Officer, Department of Paediatrics, Government District Hospital Kekri, Ajmer, Rajasthan, India.Senior Resident, Department of Paediatrics, Sardar Patel Medical College, Bikaner, Rajasthan, India.Principal Specialist, Department of Paediatrics, Sardar Patel Medical College, Bikaner, Rajasthan, India.Senior Professor, Department of Paediatrics, Sardar Patel Medical College, Bikaner, Rajasthan, India.Professor, Department of Paediatrics, Sardar Patel Medical College, Bikaner, Rajasthan, India.Introduction: Thalassaemia is one of the most common genetic disorders. Iron overload due to repeated blood transfusions and chelating therapy leads to oxidative stress and possible irreversible brain tissue damage, causing cognitive impairment in these children. Aim: To study cognitive impairment in children with beta thalassaemia major in a tertiary care centre in Bikaner, Rajasthan, India. Materials and Methods: This was a hospital-based cross-sectional observational study conducted in the Department of Paediatrics, Sardar Patel Medical College, Bikaner, Rajasthan, India from September 2019 to August 2020. Sixty-five children with thalassaemia and 65 children without thalassaemia (as controls) were recruited and assessed using modified Mini-Mental State Examination (MMSE) for cognitive impairment. Results: Majority of children belonged to age group 6-11 years (67.7% in cases and 68.8% in controls). The mean MMSE scores were significantly lower among children with thalassaemia (26.82±6.45) compared to the controls (29.08±5.71). There was a significantly higher prevalence of cognitive dysfunction in thalassaemia children (72.3%) as compared to controls (33.8%). Children who were compliant with chelation medications (n=30) were found to have a lesser prevalence of cognitive dysfunction (60%) than those who were not compliant (n=35) with medications (82.86%) (p-value=0.013). Among cases, the mean ferritin levels were higher in children with cognitive dysfunction (3399.00±1489.18) compared to those with normal cognitive function (2412.38±1117.26) (p-value=0.046). There was moderate positive correlation between thalassaemia child’s Body Mass Index (BMI) and modified MMSE score. Conclusion: This study highlights the higher prevalence of cognitive impairment in children with thalassaemia (72.3%). The key contributing factors were- lack of compliance to chelation therapy, higher serum ferritin levels and low BMI.https://jcdr.net/articles/PDF/17448/58857_CE[Ra1]_F(KM)_PF1(JY_SHU_SS)_PFA(SS)_PB(JY_SS)_PN(SS).pdfbody mass indexchelationmodified mini-mental state examinationserum ferritin |
| spellingShingle | Sandeep Avasarala Anubhav Choudhary Kuldeep Singh Bithu Renu Agrawal Gajanand Singh Tanwar Cognitive Impairment in Children with Beta-Thalassaemia Major at a Tertiary Care Centre, Rajasthan, India: A Cross-sectional Study Journal of Clinical and Diagnostic Research body mass index chelation modified mini-mental state examination serum ferritin |
| title | Cognitive Impairment in Children with Beta-Thalassaemia Major at a Tertiary Care Centre, Rajasthan, India: A Cross-sectional Study |
| title_full | Cognitive Impairment in Children with Beta-Thalassaemia Major at a Tertiary Care Centre, Rajasthan, India: A Cross-sectional Study |
| title_fullStr | Cognitive Impairment in Children with Beta-Thalassaemia Major at a Tertiary Care Centre, Rajasthan, India: A Cross-sectional Study |
| title_full_unstemmed | Cognitive Impairment in Children with Beta-Thalassaemia Major at a Tertiary Care Centre, Rajasthan, India: A Cross-sectional Study |
| title_short | Cognitive Impairment in Children with Beta-Thalassaemia Major at a Tertiary Care Centre, Rajasthan, India: A Cross-sectional Study |
| title_sort | cognitive impairment in children with beta thalassaemia major at a tertiary care centre rajasthan india a cross sectional study |
| topic | body mass index chelation modified mini-mental state examination serum ferritin |
| url | https://jcdr.net/articles/PDF/17448/58857_CE[Ra1]_F(KM)_PF1(JY_SHU_SS)_PFA(SS)_PB(JY_SS)_PN(SS).pdf |
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