Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias
Catheter ablation is a common therapy for atrial fibrillation but disrupts cardiac cholinergic neurons. Here the authors report that cholinergic neurons innervate heart ventricles and show that their ablation leads to increased susceptibility to ventricular arrhythmias in mouse models and in patient...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14155 |
| _version_ | 1818850998524837888 |
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| author | Christiane Jungen Katharina Scherschel Christian Eickholt Pawel Kuklik Niklas Klatt Nadja Bork Tim Salzbrunn Fares Alken Stephan Angendohr Christiane Klene Janos Mester Nikolaj Klöcker Marieke W. Veldkamp Udo Schumacher Stephan Willems Viacheslav O. Nikolaev Christian Meyer |
| author_facet | Christiane Jungen Katharina Scherschel Christian Eickholt Pawel Kuklik Niklas Klatt Nadja Bork Tim Salzbrunn Fares Alken Stephan Angendohr Christiane Klene Janos Mester Nikolaj Klöcker Marieke W. Veldkamp Udo Schumacher Stephan Willems Viacheslav O. Nikolaev Christian Meyer |
| author_sort | Christiane Jungen |
| collection | DOAJ |
| description | Catheter ablation is a common therapy for atrial fibrillation but disrupts cardiac cholinergic neurons. Here the authors report that cholinergic neurons innervate heart ventricles and show that their ablation leads to increased susceptibility to ventricular arrhythmias in mouse models and in patients. |
| first_indexed | 2024-12-19T06:58:02Z |
| format | Article |
| id | doaj.art-cb15526be5334b77bb985b10ebd7ca12 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T06:58:02Z |
| publishDate | 2017-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cb15526be5334b77bb985b10ebd7ca122022-12-21T20:31:29ZengNature PortfolioNature Communications2041-17232017-01-018111310.1038/ncomms14155Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmiasChristiane Jungen0Katharina Scherschel1Christian Eickholt2Pawel Kuklik3Niklas Klatt4Nadja Bork5Tim Salzbrunn6Fares Alken7Stephan Angendohr8Christiane Klene9Janos Mester10Nikolaj Klöcker11Marieke W. Veldkamp12Udo Schumacher13Stephan Willems14Viacheslav O. Nikolaev15Christian Meyer16Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-EppendorfDepartment of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-EppendorfDepartment of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-EppendorfDepartment of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-EppendorfDepartment of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-EppendorfDZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/LübeckDepartment of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-EppendorfDepartment of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-EppendorfDepartment of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-EppendorfDepartment of Nuclear Medicine, University Medical Center Hamburg-EppendorfDepartment of Nuclear Medicine, University Medical Center Hamburg-EppendorfInstitute of Neural and Sensory Physiology, Medical Faculty, University of DüsseldorfDepartment of Clinical and Experimental Cardiology, Academic Medical Center, University of AmsterdamInstitute of Anatomy and Experimental Morphology, University Cancer Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-EppendorfDZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/LübeckDepartment of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-EppendorfCatheter ablation is a common therapy for atrial fibrillation but disrupts cardiac cholinergic neurons. Here the authors report that cholinergic neurons innervate heart ventricles and show that their ablation leads to increased susceptibility to ventricular arrhythmias in mouse models and in patients.https://doi.org/10.1038/ncomms14155 |
| spellingShingle | Christiane Jungen Katharina Scherschel Christian Eickholt Pawel Kuklik Niklas Klatt Nadja Bork Tim Salzbrunn Fares Alken Stephan Angendohr Christiane Klene Janos Mester Nikolaj Klöcker Marieke W. Veldkamp Udo Schumacher Stephan Willems Viacheslav O. Nikolaev Christian Meyer Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias Nature Communications |
| title | Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias |
| title_full | Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias |
| title_fullStr | Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias |
| title_full_unstemmed | Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias |
| title_short | Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias |
| title_sort | disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias |
| url | https://doi.org/10.1038/ncomms14155 |
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