Improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer-a propensity score-matched study
Abstract Background Dysfunctional uterine peristalsis seems to play a pivotal role in hindering embryo implantation among women diagnosed with adenomyosis. This research aims to investigate whether administering an oxytocin receptor antagonist during a frozen embryo transfer (FET) cycle using a horm...
| Main Authors: | , , , , , |
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| פורמט: | Article |
| שפה: | English |
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BMC
2024-07-01
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| סדרה: | Reproductive Biology and Endocrinology |
| נושאים: | |
| גישה מקוונת: | https://doi.org/10.1186/s12958-024-01255-1 |
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| author | Po-Wen Lin Chyi-Uei Chern Chia-Jung Li Pei-Hsuan Lin Kuan-Hao Tsui Li-Te Lin |
| author_facet | Po-Wen Lin Chyi-Uei Chern Chia-Jung Li Pei-Hsuan Lin Kuan-Hao Tsui Li-Te Lin |
| author_sort | Po-Wen Lin |
| collection | DOAJ |
| description | Abstract Background Dysfunctional uterine peristalsis seems to play a pivotal role in hindering embryo implantation among women diagnosed with adenomyosis. This research aims to investigate whether administering an oxytocin receptor antagonist during a frozen embryo transfer (FET) cycle using a hormone replacement therapy (HRT) protocol can enhance in vitro fertilization (IVF) outcomes for infertile women affected by adenomyosis. Methods Between January 2018 and June 2022, our reproductive center conducted IVF-FET HRT cycles for infertile women diagnosed with adenomyosis. Propensity score matching was employed to select matched subjects between the two groups in a 1:1 ratio. Following this, 168 women received an oxytocin receptor antagonist during FET, constituting the study group, while the matched 168 women underwent FET without this antagonist, forming the control group. We conducted comparative analyses of baseline and cycle characteristics between the two groups, along with additional subgroup analyses. Results The study group exhibited notably lower rates of early miscarriage compared to the control group, although there were no significant differences in clinical pregnancy rates, ongoing pregnancy rates, and live birth rates between the two groups. Multivariate analysis revealed a negative correlation between the use of oxytocin receptor antagonists and early miscarriage rates in women with adenomyosis. Subgroup analyses, categorized by age, infertility types, and embryo transfer day, showed a substantial decrease in early miscarriage rates within specific subgroups: women aged ≥ 37 years, those with secondary infertility, and individuals undergoing day 3 embryo transfers in the study group compared to the control group. Furthermore, subgroup analysis based on adenomyosis types indicated significantly higher clinical pregnancy rates, ongoing pregnancy rates and live birth rates in the study group compared to the control group among women with diffuse adenomyosis. Conclusions Administering an oxytocin receptor antagonist during FET may reduce the early miscarriage rates in women with adenomyosis. |
| first_indexed | 2025-03-21T07:42:18Z |
| format | Article |
| id | doaj.art-cb15d56e8e3c423daca36a55e8d96a49 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2025-03-21T07:42:18Z |
| publishDate | 2024-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-cb15d56e8e3c423daca36a55e8d96a492024-07-14T11:35:17ZengBMCReproductive Biology and Endocrinology1477-78272024-07-0122111110.1186/s12958-024-01255-1Improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer-a propensity score-matched studyPo-Wen Lin0Chyi-Uei Chern1Chia-Jung Li2Pei-Hsuan Lin3Kuan-Hao Tsui4Li-Te Lin5Department of Obstetrics and Gynecology, Kaohsiung Veterans General HospitalDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General HospitalDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General HospitalDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General HospitalDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General HospitalDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General HospitalAbstract Background Dysfunctional uterine peristalsis seems to play a pivotal role in hindering embryo implantation among women diagnosed with adenomyosis. This research aims to investigate whether administering an oxytocin receptor antagonist during a frozen embryo transfer (FET) cycle using a hormone replacement therapy (HRT) protocol can enhance in vitro fertilization (IVF) outcomes for infertile women affected by adenomyosis. Methods Between January 2018 and June 2022, our reproductive center conducted IVF-FET HRT cycles for infertile women diagnosed with adenomyosis. Propensity score matching was employed to select matched subjects between the two groups in a 1:1 ratio. Following this, 168 women received an oxytocin receptor antagonist during FET, constituting the study group, while the matched 168 women underwent FET without this antagonist, forming the control group. We conducted comparative analyses of baseline and cycle characteristics between the two groups, along with additional subgroup analyses. Results The study group exhibited notably lower rates of early miscarriage compared to the control group, although there were no significant differences in clinical pregnancy rates, ongoing pregnancy rates, and live birth rates between the two groups. Multivariate analysis revealed a negative correlation between the use of oxytocin receptor antagonists and early miscarriage rates in women with adenomyosis. Subgroup analyses, categorized by age, infertility types, and embryo transfer day, showed a substantial decrease in early miscarriage rates within specific subgroups: women aged ≥ 37 years, those with secondary infertility, and individuals undergoing day 3 embryo transfers in the study group compared to the control group. Furthermore, subgroup analysis based on adenomyosis types indicated significantly higher clinical pregnancy rates, ongoing pregnancy rates and live birth rates in the study group compared to the control group among women with diffuse adenomyosis. Conclusions Administering an oxytocin receptor antagonist during FET may reduce the early miscarriage rates in women with adenomyosis.https://doi.org/10.1186/s12958-024-01255-1Oxytocin receptor antagonistAtosibanAdenomyosisFrozen embryo transferIn vitro fertilization |
| spellingShingle | Po-Wen Lin Chyi-Uei Chern Chia-Jung Li Pei-Hsuan Lin Kuan-Hao Tsui Li-Te Lin Improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer-a propensity score-matched study Reproductive Biology and Endocrinology Oxytocin receptor antagonist Atosiban Adenomyosis Frozen embryo transfer In vitro fertilization |
| title | Improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer-a propensity score-matched study |
| title_full | Improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer-a propensity score-matched study |
| title_fullStr | Improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer-a propensity score-matched study |
| title_full_unstemmed | Improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer-a propensity score-matched study |
| title_short | Improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer-a propensity score-matched study |
| title_sort | improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer a propensity score matched study |
| topic | Oxytocin receptor antagonist Atosiban Adenomyosis Frozen embryo transfer In vitro fertilization |
| url | https://doi.org/10.1186/s12958-024-01255-1 |
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