Altered Serum Lipids and Paraoxonase Activity: A Step towards Atherosclerosis among Lead Exposed Egyptian Workers
A vast amount of evidence during the past decade, has confirmed that lead is associated with lipid and lipoprotein abnormalities which play a major role in the pathogenesis and progression of atherosclerosis and cardiovascular diseases. This study aimed: to investigate the relationship between chron...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Alexandria University
2009-09-01
|
| Series: | Journal of High Institute of Public Health |
| Subjects: |
| _version_ | 1819059034425131008 |
|---|---|
| author | Manal Kamal Mona Fathy Eman Taher Manal Hasan |
| author_facet | Manal Kamal Mona Fathy Eman Taher Manal Hasan |
| author_sort | Manal Kamal |
| collection | DOAJ |
| description | A vast amount of evidence during the past decade, has confirmed that lead is associated with lipid and lipoprotein abnormalities which play a major role in the pathogenesis and progression of atherosclerosis and cardiovascular diseases. This study aimed: to investigate the relationship between chronic occupational lead exposure, lipid profile, and serum PON1 activity as one of the mechanisms of atherosclerosis. Male workers (n=100) in lead battery manufactory were recruited for this study. They were compared with 100 male age matched non-lead workers. Serum lipid profile and paraoxonase activity were done to their samples. Serum Lead was determined vsing atomic absorption spectroscopy. There was significant differences regarding triglycerides, total cholesterol, and HDL-c (p=0.01, 0.05 and 0.04, respectively) between both groups. A cumulative effect of blood lead on lipid profile was significantly detected. Multiple linear regression analysis showed that blood lead level was the only negative significant predictors to serum paraoxonase activity (p=0.03) in lead workers. lead exposure is associated with increased triglycerides, total cholesterol and LDL-c and decrease HDL-c. Because of the protective role of PON1 in the development of atherosclerosis, decrease in serum PON1 activity due to lead exposure may render individuals more susceptible to atherosclerosis. |
| first_indexed | 2024-12-21T14:04:41Z |
| format | Article |
| id | doaj.art-cb1912a05921407eb5d26892f679ad98 |
| institution | Directory Open Access Journal |
| issn | 2357-0601 2357-061X |
| language | English |
| last_indexed | 2024-12-21T14:04:41Z |
| publishDate | 2009-09-01 |
| publisher | Alexandria University |
| record_format | Article |
| series | Journal of High Institute of Public Health |
| spelling | doaj.art-cb1912a05921407eb5d26892f679ad982022-12-21T19:01:16ZengAlexandria UniversityJournal of High Institute of Public Health2357-06012357-061X2009-09-0139353755010.21608/JHIPH.2009.20851Altered Serum Lipids and Paraoxonase Activity: A Step towards Atherosclerosis among Lead Exposed Egyptian WorkersManal Kamal0Mona Fathy1Eman Taher2Manal Hasan3Clinical and Chemical Pathology, Community Medicine, Faculty of Medicine, Cairo University, Cairo, EgyptClinical and Chemical Pathology, Community Medicine, Faculty of Medicine, Cairo University, Cairo, EgyptClinical and Chemical Pathology, Community Medicine, Faculty of Medicine, Cairo University, Cairo, EgyptIndustrial Medicine and Occupational diseases, Faculty of Medicine, Cairo University, Cairo, EgyptA vast amount of evidence during the past decade, has confirmed that lead is associated with lipid and lipoprotein abnormalities which play a major role in the pathogenesis and progression of atherosclerosis and cardiovascular diseases. This study aimed: to investigate the relationship between chronic occupational lead exposure, lipid profile, and serum PON1 activity as one of the mechanisms of atherosclerosis. Male workers (n=100) in lead battery manufactory were recruited for this study. They were compared with 100 male age matched non-lead workers. Serum lipid profile and paraoxonase activity were done to their samples. Serum Lead was determined vsing atomic absorption spectroscopy. There was significant differences regarding triglycerides, total cholesterol, and HDL-c (p=0.01, 0.05 and 0.04, respectively) between both groups. A cumulative effect of blood lead on lipid profile was significantly detected. Multiple linear regression analysis showed that blood lead level was the only negative significant predictors to serum paraoxonase activity (p=0.03) in lead workers. lead exposure is associated with increased triglycerides, total cholesterol and LDL-c and decrease HDL-c. Because of the protective role of PON1 in the development of atherosclerosis, decrease in serum PON1 activity due to lead exposure may render individuals more susceptible to atherosclerosis.serum lipidsparaoxonase activityatherosclerosislead exposureegyptian workers |
| spellingShingle | Manal Kamal Mona Fathy Eman Taher Manal Hasan Altered Serum Lipids and Paraoxonase Activity: A Step towards Atherosclerosis among Lead Exposed Egyptian Workers Journal of High Institute of Public Health serum lipids paraoxonase activity atherosclerosis lead exposure egyptian workers |
| title | Altered Serum Lipids and Paraoxonase Activity: A Step towards Atherosclerosis among Lead Exposed Egyptian Workers |
| title_full | Altered Serum Lipids and Paraoxonase Activity: A Step towards Atherosclerosis among Lead Exposed Egyptian Workers |
| title_fullStr | Altered Serum Lipids and Paraoxonase Activity: A Step towards Atherosclerosis among Lead Exposed Egyptian Workers |
| title_full_unstemmed | Altered Serum Lipids and Paraoxonase Activity: A Step towards Atherosclerosis among Lead Exposed Egyptian Workers |
| title_short | Altered Serum Lipids and Paraoxonase Activity: A Step towards Atherosclerosis among Lead Exposed Egyptian Workers |
| title_sort | altered serum lipids and paraoxonase activity a step towards atherosclerosis among lead exposed egyptian workers |
| topic | serum lipids paraoxonase activity atherosclerosis lead exposure egyptian workers |
| work_keys_str_mv | AT manalkamal alteredserumlipidsandparaoxonaseactivityasteptowardsatherosclerosisamongleadexposedegyptianworkers AT monafathy alteredserumlipidsandparaoxonaseactivityasteptowardsatherosclerosisamongleadexposedegyptianworkers AT emantaher alteredserumlipidsandparaoxonaseactivityasteptowardsatherosclerosisamongleadexposedegyptianworkers AT manalhasan alteredserumlipidsandparaoxonaseactivityasteptowardsatherosclerosisamongleadexposedegyptianworkers |