Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia

Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia

Epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. Intriguingly, p73 displays a very specific localization to basal epithelial cells in human tissues, while p63 is expressed in...

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Bibliographic Details
Main Authors: Julian M. Rozenberg, Olga S. Rogovaya, Gerry Melino, Nickolai A. Barlev, Alexander Kagansky
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
p53
p63
p73
protein interactions
Online Access:https://www.mdpi.com/2073-4409/10/1/25

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