Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR
Translation of ATF4 mRNA is stimulated during the integrated stress response. Here the authors show that two noncanonical translation initiation factors eIF2D and DENR are required for translational induction of ATF4 mRNA in Drosophila and human cells.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18453-1 |
| _version_ | 1818846010292568064 |
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| author | Deepika Vasudevan Sarah D. Neuman Amy Yang Lea Lough Brian Brown Arash Bashirullah Timothy Cardozo Hyung Don Ryoo |
| author_facet | Deepika Vasudevan Sarah D. Neuman Amy Yang Lea Lough Brian Brown Arash Bashirullah Timothy Cardozo Hyung Don Ryoo |
| author_sort | Deepika Vasudevan |
| collection | DOAJ |
| description | Translation of ATF4 mRNA is stimulated during the integrated stress response. Here the authors show that two noncanonical translation initiation factors eIF2D and DENR are required for translational induction of ATF4 mRNA in Drosophila and human cells. |
| first_indexed | 2024-12-19T05:38:45Z |
| format | Article |
| id | doaj.art-cb19d805a6b24e2eacdacbc663f41ff9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T05:38:45Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cb19d805a6b24e2eacdacbc663f41ff92022-12-21T20:34:04ZengNature PortfolioNature Communications2041-17232020-09-0111111110.1038/s41467-020-18453-1Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENRDeepika Vasudevan0Sarah D. Neuman1Amy Yang2Lea Lough3Brian Brown4Arash Bashirullah5Timothy Cardozo6Hyung Don Ryoo7Department of Cell Biology, New York University Grossman School of MedicineDepartment of Pharmaceutical Sciences, University of Wisconsin-MadisonDepartment of Cell Biology, New York University Grossman School of MedicineDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of MedicineDepartment of Cell Biology, New York University Grossman School of MedicineDepartment of Pharmaceutical Sciences, University of Wisconsin-MadisonDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of MedicineDepartment of Cell Biology, New York University Grossman School of MedicineTranslation of ATF4 mRNA is stimulated during the integrated stress response. Here the authors show that two noncanonical translation initiation factors eIF2D and DENR are required for translational induction of ATF4 mRNA in Drosophila and human cells.https://doi.org/10.1038/s41467-020-18453-1 |
| spellingShingle | Deepika Vasudevan Sarah D. Neuman Amy Yang Lea Lough Brian Brown Arash Bashirullah Timothy Cardozo Hyung Don Ryoo Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR Nature Communications |
| title | Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR |
| title_full | Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR |
| title_fullStr | Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR |
| title_full_unstemmed | Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR |
| title_short | Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR |
| title_sort | translational induction of atf4 during integrated stress response requires noncanonical initiation factors eif2d and denr |
| url | https://doi.org/10.1038/s41467-020-18453-1 |
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