Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease.
AGGF1 is an angiogenic factor with therapeutic potential to treat coronary artery disease (CAD) and myocardial infarction (MI). However, the underlying mechanism for AGGF1-mediated therapeutic angiogenesis is unknown. Here, we show for the first time that AGGF1 activates autophagy, a housekeeping ca...
Main Authors: | Qiulun Lu, Yufeng Yao, Zhenkun Hu, Changqing Hu, Qixue Song, Jian Ye, Chengqi Xu, Annabel Z Wang, Qiuyun Chen, Qing Kenneth Wang |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-08-01
|
Series: | PLoS Biology |
Online Access: | https://doi.org/10.1371/journal.pbio.1002529 |
Similar Items
-
Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury
by: Yufeng Yao, et al.
Published: (2017-11-01) -
Angiogenic factor AGGF1 promotes therapeutic angiogenesis in a mouse limb ischemia model.
by: Qiulun Lu, et al.
Published: (2012-01-01) -
Protein therapy of skeletal muscle atrophy and mechanism by angiogenic factor AGGF1
by: Zuhan He, et al.
Published: (2023-04-01) -
The Effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 Axis Regulating Glioblastoma Angiogenesis
by: Chunqing Yang, et al.
Published: (2018-01-01) -
AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing integrin α7-mediated inhibition of TGF-β1 maturation and ERK1/2 signaling
by: Xingwen Da, et al.
Published: (2023-04-01)